ENSGALG00000003770


Gallus gallus

Features
Gene ID: ENSGALG00000003770
  
Biological name :ANXA2
  
Synonyms : Annexin A2 / ANXA2 / P17785
  
Possible biological names infered from orthology : P07355 / P07356
  
Species: Gallus gallus
  
Chr. number: 10
Strand: 1
Band:
Gene start: 5019352
Gene end: 5044352
  
Corresponding Affymetrix probe sets: Gga.3641.1.S1_at (Chicken Array)   Gga.5092.1.A1_at (Chicken Array)   Gga.5092.1.S1_s_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000059946
Ensembl peptide - ENSGALP00000063929
Ensembl peptide - ENSGALP00000060891
Ensembl peptide - ENSGALP00000005971
Ensembl peptide - ENSGALP00000048954
Ensembl peptide - ENSGALP00000058235
NCBI entrez gene - 396297     See in Manteia.
RefSeq - NM_205351
RefSeq - XM_015278763
RefSeq Peptide - NP_990682
swissprot - A0A1D5PZ27
swissprot - A0A1C9KD18
swissprot - P17785
Ensembl - ENSGALG00000003770
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 anxa2aENSDARG00000003216Danio rerio
 anxa2bENSDARG00000053625Danio rerio
 ANXA2ENSG00000182718Homo sapiens
 Anxa2ENSMUSG00000032231Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
ANXA1 / annexin A1 / P04083* / P10107*ENSGALG0000001514853
ANXA11 / annexin A11 / P50995* / P97384*ENSGALG0000004382646
ANXA4 / annexin A4 / P09525* / P97429* / Mus musculus annexin A4 (Anxa4), transcript variant 1, mRNA.*ENSGALG0000003878345
ANXA5 / P17153 / Annexin A5 / P08758* / P48036*ENSGALG0000001188543
ANXA6 / annexin A6 / P08133* / P14824*ENSGALG0000000435743
ANXA7 / annexin A7 / P20073* / Q07076*ENSGALG0000000529941
ANXA8* / Q5VT79* / O35640* / P13928* / ANXA8L1* / annexin A8* / annexin A8 like 1*ENSGALG0000000595641
ANXA13 / annexin A13 / P27216*ENSGALG0000003641839


Protein motifs (from Interpro)
Interpro ID Name
 IPR001464  Annexin
 IPR002389  Annexin A2
 IPR018252  Annexin repeat, conserved site
 IPR018502  Annexin repeat


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001525 angiogenesis IEA
 biological_processGO:0001765 membrane raft assembly IEA
 biological_processGO:0001921 positive regulation of receptor recycling IEA
 biological_processGO:0003417 growth plate cartilage development IDA
 biological_processGO:0006900 vesicle budding from membrane IEA
 biological_processGO:0010755 regulation of plasminogen activation IDA
 biological_processGO:0030199 collagen fibril organization IEA
 biological_processGO:0030282 bone mineralization TAS
 biological_processGO:0031340 positive regulation of vesicle fusion IEA
 biological_processGO:0032332 positive regulation of chondrocyte differentiation IDA
 biological_processGO:0032804 negative regulation of low-density lipoprotein particle receptor catabolic process IEA
 biological_processGO:0032907 transforming growth factor beta3 production IDA
 biological_processGO:0036035 osteoclast development IEA
 biological_processGO:0036366 transforming growth factor beta3 activation IDA
 biological_processGO:0042730 fibrinolysis IEA
 biological_processGO:0043086 negative regulation of catalytic activity IEA
 biological_processGO:0044090 positive regulation of vacuole organization IEA
 biological_processGO:0044147 negative regulation of development of symbiont involved in interaction with host IEA
 biological_processGO:0051099 positive regulation of binding IEA
 biological_processGO:0051290 protein heterotetramerization IEA
 biological_processGO:0051480 regulation of cytosolic calcium ion concentration IEA
 biological_processGO:0051928 positive regulation of calcium ion transport IDA
 biological_processGO:0052362 catabolism by host of symbiont protein IEA
 biological_processGO:0052405 negative regulation by host of symbiont molecular function IEA
 biological_processGO:0055074 calcium ion homeostasis TAS
 biological_processGO:0060956 endocardial cell differentiation IDA
 biological_processGO:0070588 calcium ion transmembrane transport IEA
 biological_processGO:1905581 positive regulation of low-density lipoprotein particle clearance IEA
 biological_processGO:1905597 positive regulation of low-density lipoprotein particle receptor binding IEA
 biological_processGO:1905599 positive regulation of low-density lipoprotein receptor activity IEA
 biological_processGO:1905602 positive regulation of receptor-mediated endocytosis involved in cholesterol transport IEA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005604 basement membrane IEA
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005765 lysosomal membrane IEA
 cellular_componentGO:0005768 endosome IEA
 cellular_componentGO:0005769 early endosome IEA
 cellular_componentGO:0005811 lipid droplet IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005886 plasma membrane IDA
 cellular_componentGO:0005913 cell-cell adherens junction IEA
 cellular_componentGO:0009986 cell surface IEA
 cellular_componentGO:0016323 basolateral plasma membrane IEA
 cellular_componentGO:0019897 extrinsic component of plasma membrane IEA
 cellular_componentGO:0030496 midbody IEA
 cellular_componentGO:0031012 extracellular matrix IDA
 cellular_componentGO:0031902 late endosome membrane IEA
 cellular_componentGO:0031982 vesicle TAS
 cellular_componentGO:0032991 protein-containing complex TAS
 cellular_componentGO:0034704 calcium channel complex TAS
 cellular_componentGO:0035749 myelin sheath adaxonal region IEA
 cellular_componentGO:0042383 sarcolemma IEA
 cellular_componentGO:0043220 Schmidt-Lanterman incisure IEA
 cellular_componentGO:0045121 membrane raft IEA
 cellular_componentGO:0070062 extracellular exosome IEA
 cellular_componentGO:1990667 PCSK9-AnxA2 complex IEA
 molecular_functionGO:0002020 protease binding IEA
 molecular_functionGO:0004859 phospholipase inhibitor activity IEA
 molecular_functionGO:0005262 calcium channel activity TAS
 molecular_functionGO:0005509 calcium ion binding IEA
 molecular_functionGO:0005544 calcium-dependent phospholipid binding IEA
 molecular_functionGO:0005546 phosphatidylinositol-4,5-bisphosphate binding IEA
 molecular_functionGO:0008092 cytoskeletal protein binding IEA
 molecular_functionGO:0019834 phospholipase A2 inhibitor activity IEA
 molecular_functionGO:0042802 identical protein binding IEA
 molecular_functionGO:0044548 S100 protein binding IEA
 molecular_functionGO:0046790 virion binding IDA
 molecular_functionGO:0048306 calcium-dependent protein binding IEA
 molecular_functionGO:0098641 cadherin binding involved in cell-cell adhesion IEA
 molecular_functionGO:0098772 molecular function regulator IEA
 molecular_functionGO:0099511 voltage-gated calcium channel activity involved in regulation of cytosolic calcium levels TAS


Pathways (from Reactome)
Pathway description
Neutrophil degranulation
Dissolution of Fibrin Clot


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000003770 ANXA2 / P17785 / Annexin A2 / P07355* / P07356*  / complex
 ENSGALG00000028774 P27003 / S100A10 / Protein S100-A10 / P60903* / P08207* / S100 calcium binding protein A10* / S100 calcium binding protein A10 (calpactin)*  / complex






 

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