ENSG00000182718


Homo sapiens

Features
Gene ID: ENSG00000182718
  
Biological name :ANXA2
  
Synonyms : annexin A2 / ANXA2 / P07355
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 15
Strand: -1
Band: q22.2
Gene start: 60347134
Gene end: 60402883
  
Corresponding Affymetrix probe sets: 1568126_at (Human Genome U133 Plus 2.0 Array)   201590_x_at (Human Genome U133 Plus 2.0 Array)   210427_x_at (Human Genome U133 Plus 2.0 Array)   213503_x_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000452921
Ensembl peptide - ENSP00000453694
Ensembl peptide - ENSP00000453739
Ensembl peptide - ENSP00000453742
Ensembl peptide - ENSP00000453754
Ensembl peptide - ENSP00000453770
Ensembl peptide - ENSP00000453841
Ensembl peptide - ENSP00000453859
Ensembl peptide - ENSP00000453869
Ensembl peptide - ENSP00000453925
Ensembl peptide - ENSP00000453945
Ensembl peptide - ENSP00000454096
Ensembl peptide - ENSP00000346032
Ensembl peptide - ENSP00000379342
Ensembl peptide - ENSP00000387545
Ensembl peptide - ENSP00000411352
Ensembl peptide - ENSP00000452858
Ensembl peptide - ENSP00000452876
Ensembl peptide - ENSP00000452895
Ensembl peptide - ENSP00000452958
Ensembl peptide - ENSP00000452981
Ensembl peptide - ENSP00000453000
Ensembl peptide - ENSP00000453039
Ensembl peptide - ENSP00000453174
Ensembl peptide - ENSP00000453356
Ensembl peptide - ENSP00000453464
Ensembl peptide - ENSP00000453556
Ensembl peptide - ENSP00000453566
Ensembl peptide - ENSP00000453579
Ensembl peptide - ENSP00000453663
NCBI entrez gene - 302     See in Manteia.
OMIM - 151740
RefSeq - XM_011521477
RefSeq - NM_004039
RefSeq - NM_001136015
RefSeq - NM_001002858
RefSeq - XM_017022092
RefSeq - XM_017022091
RefSeq - NM_001002857
RefSeq - XM_017022090
RefSeq - XM_017022093
RefSeq Peptide - NP_001002858
RefSeq Peptide - NP_001002857
RefSeq Peptide - NP_001129487
RefSeq Peptide - NP_004030
swissprot - H0YMM1
swissprot - H0YMT9
swissprot - H0YMU9
swissprot - H0YMW4
swissprot - H0YN28
swissprot - H0YN42
swissprot - H0YN52
swissprot - H0YNA0
swissprot - H0YNB8
swissprot - H0YNP5
swissprot - H0YLV6
swissprot - H0YLE2
swissprot - H0YL33
swissprot - H0YKZ7
swissprot - H0YKN4
swissprot - H0YKX9
swissprot - H0YKL9
swissprot - A0A024R5Z7
swissprot - P07355
swissprot - H0YKV8
swissprot - H0YKS4
swissprot - H0YM50
swissprot - H0YMD0
swissprot - H0YMD9
Ensembl - ENSG00000182718
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 anxa2aENSDARG00000003216Danio rerio
 anxa2bENSDARG00000053625Danio rerio
 ANXA2ENSGALG00000003770Gallus gallus
 Anxa2ENSMUSG00000032231Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
ANXA1 / P04083 / annexin A1ENSG0000013504650
ANXA11 / P50995 / annexin A11ENSG0000012235944
ANXA6 / P08133 / annexin A6ENSG0000019704343
ANXA4 / P09525 / annexin A4ENSG0000019697543
ANXA3 / P12429 / annexin A3ENSG0000013877243
ANXA5 / P08758 / annexin A5ENSG0000016411141
ANXA8 / P13928 / annexin A8ENSG0000026519041
Q5VT79 / ANXA8L1 / annexin A8 like 1ENSG0000026423041
ANXA7 / P20073 / annexin A7ENSG0000013827940
ANXA13 / P27216 / annexin A13ENSG0000010453738


Protein motifs (from Interpro)
Interpro ID Name
 IPR001464  Annexin
 IPR002389  Annexin A2
 IPR018252  Annexin repeat, conserved site
 IPR018502  Annexin repeat
 IPR037104  Annexin superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001525 angiogenesis IEP
 biological_processGO:0001765 membrane raft assembly IMP
 biological_processGO:0001921 positive regulation of receptor recycling IDA
 biological_processGO:0001934 positive regulation of protein phosphorylation IEA
 biological_processGO:0006900 vesicle budding from membrane IMP
 biological_processGO:0007589 body fluid secretion IEA
 biological_processGO:0030199 collagen fibril organization IEA
 biological_processGO:0031340 positive regulation of vesicle fusion IDA
 biological_processGO:0032804 negative regulation of low-density lipoprotein particle receptor catabolic process IDA
 biological_processGO:0035722 interleukin-12-mediated signaling pathway TAS
 biological_processGO:0036035 osteoclast development IDA
 biological_processGO:0042730 fibrinolysis IEA
 biological_processGO:0043086 negative regulation of catalytic activity IEA
 biological_processGO:0043312 neutrophil degranulation TAS
 biological_processGO:0044090 positive regulation of vacuole organization IMP
 biological_processGO:0044147 negative regulation of development of symbiont involved in interaction with host IMP
 biological_processGO:0048146 positive regulation of fibroblast proliferation IEA
 biological_processGO:0051099 positive regulation of binding IEA
 biological_processGO:0051290 protein heterotetramerization IDA
 biological_processGO:0052362 catabolism by host of symbiont protein IMP
 biological_processGO:0052405 negative regulation by host of symbiont molecular function IMP
 biological_processGO:0072659 protein localization to plasma membrane IEA
 biological_processGO:0097066 response to thyroid hormone IEA
 biological_processGO:0098609 cell-cell adhesion IEA
 biological_processGO:1905581 positive regulation of low-density lipoprotein particle clearance IDA
 biological_processGO:1905597 positive regulation of low-density lipoprotein particle receptor binding IDA
 biological_processGO:1905599 positive regulation of low-density lipoprotein receptor activity IMP
 biological_processGO:1905602 positive regulation of receptor-mediated endocytosis involved in cholesterol transport IDA
 cellular_componentGO:0001726 ruffle IEA
 cellular_componentGO:0005576 extracellular region IDA
 cellular_componentGO:0005604 basement membrane IEA
 cellular_componentGO:0005615 extracellular space HDA
 cellular_componentGO:0005634 nucleus HDA
 cellular_componentGO:0005737 cytoplasm IDA
 cellular_componentGO:0005765 lysosomal membrane IDA
 cellular_componentGO:0005768 endosome IDA
 cellular_componentGO:0005769 early endosome IEA
 cellular_componentGO:0005811 lipid droplet IDA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005886 plasma membrane IDA
 cellular_componentGO:0005913 cell-cell adherens junction IDA
 cellular_componentGO:0005938 cell cortex IEA
 cellular_componentGO:0009986 cell surface IDA
 cellular_componentGO:0016020 membrane HDA
 cellular_componentGO:0016323 basolateral plasma membrane ISS
 cellular_componentGO:0019897 extrinsic component of plasma membrane IEA
 cellular_componentGO:0030496 midbody IDA
 cellular_componentGO:0031012 extracellular matrix ISS
 cellular_componentGO:0031902 late endosome membrane IDA
 cellular_componentGO:0031982 vesicle HDA
 cellular_componentGO:0035578 azurophil granule lumen TAS
 cellular_componentGO:0035749 myelin sheath adaxonal region IEA
 cellular_componentGO:0042383 sarcolemma IEA
 cellular_componentGO:0042470 melanosome IEA
 cellular_componentGO:0043220 Schmidt-Lanterman incisure IEA
 cellular_componentGO:0044354 macropinosome IEA
 cellular_componentGO:0045121 membrane raft IDA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 cellular_componentGO:0070062 extracellular exosome IDA
 cellular_componentGO:1990667 PCSK9-AnxA2 complex IDA
 molecular_functionGO:0002020 protease binding IPI
 molecular_functionGO:0003723 RNA binding IEA
 molecular_functionGO:0004859 phospholipase inhibitor activity IEA
 molecular_functionGO:0005509 calcium ion binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005544 calcium-dependent phospholipid binding IEA
 molecular_functionGO:0005546 phosphatidylinositol-4,5-bisphosphate binding IMP
 molecular_functionGO:0008092 cytoskeletal protein binding IEA
 molecular_functionGO:0017137 Rab GTPase binding IEA
 molecular_functionGO:0019834 phospholipase A2 inhibitor activity IDA
 molecular_functionGO:0042802 identical protein binding IPI
 molecular_functionGO:0044548 S100 protein binding IPI
 molecular_functionGO:0044730 bone sialoprotein binding IEA
 molecular_functionGO:0048306 calcium-dependent protein binding IPI
 molecular_functionGO:0098641 cadherin binding involved in cell-cell adhesion IDA
 molecular_functionGO:0098772 molecular function regulator IDA


Pathways (from Reactome)
Pathway description
Smooth Muscle Contraction
Neutrophil degranulation
Dissolution of Fibrin Clot
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000135046 ANXA1 / P04083 / annexin A1  / reaction
 ENSG00000135636 DYSF / O75923 / dysferlin  / reaction
 ENSG00000182718 ANXA2 / P07355 / annexin A2  / complex
 ENSG00000182533 CAV3 / P56539 / caveolin 3  / reaction
 ENSG00000177238 Q6ZMU5 / TRIM72 / tripartite motif containing 72  / reaction
 ENSG00000197043 ANXA6 / P08133 / annexin A6  / reaction
 ENSG00000197747 P60903 / S100A10 / S100 calcium binding protein A10  / complex






 

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