ENSG00000122359


Homo sapiens

Features
Gene ID: ENSG00000122359
  
Biological name :ANXA11
  
Synonyms : annexin A11 / ANXA11 / P50995
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 10
Strand: -1
Band: q22.3
Gene start: 80150889
Gene end: 80205572
  
Corresponding Affymetrix probe sets: 206200_s_at (Human Genome U133 Plus 2.0 Array)   214783_s_at (Human Genome U133 Plus 2.0 Array)   228727_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000414642
Ensembl peptide - ENSP00000404412
Ensembl peptide - ENSP00000405009
Ensembl peptide - ENSP00000265447
Ensembl peptide - ENSP00000361305
Ensembl peptide - ENSP00000398610
NCBI entrez gene - 311     See in Manteia.
OMIM - 602572
RefSeq - XM_011539736
RefSeq - NM_001157
RefSeq - NM_001278407
RefSeq - NM_001278408
RefSeq - NM_001278409
RefSeq - NM_145868
RefSeq - NM_145869
RefSeq - XM_005269741
RefSeq - XM_005269742
RefSeq - XM_006717813
RefSeq - XM_006717814
RefSeq - XM_011539735
RefSeq Peptide - NP_665875
RefSeq Peptide - NP_001265336
RefSeq Peptide - NP_001265337
RefSeq Peptide - NP_001265338
RefSeq Peptide - NP_665876
RefSeq Peptide - NP_001148
swissprot - P50995
swissprot - Q5T0G7
swissprot - Q5T0G8
swissprot - H0Y6E1
Ensembl - ENSG00000122359
  
Related genetic diseases (OMIM): 617839 - Amytrophic lateral sclerosis 23, 617839
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 anxa11aENSDARG00000077383Danio rerio
 anxa11bENSDARG00000002632Danio rerio
 ANXA11ENSGALG00000043826Gallus gallus
 Anxa11ENSMUSG00000021866Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
ANXA7 / P20073 / annexin A7ENSG0000013827949
ANXA6 / P08133 / annexin A6ENSG0000019704336
ANXA4 / P09525 / annexin A4ENSG0000019697536
Q5VT79 / ANXA8L1 / annexin A8 like 1ENSG0000026423034
ANXA8 / P13928 / annexin A8ENSG0000026519034
ANXA5 / P08758 / annexin A5ENSG0000016411133
ANXA3 / P12429 / annexin A3ENSG0000013877233
ANXA13 / P27216 / annexin A13ENSG0000010453731
ANXA1 / P04083 / annexin A1ENSG0000013504631
ANXA2 / P07355 / annexin A2ENSG0000018271831


Protein motifs (from Interpro)
Interpro ID Name
 IPR001464  Annexin
 IPR008157  Annexin A11
 IPR018252  Annexin repeat, conserved site
 IPR018502  Annexin repeat
 IPR037104  Annexin superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006909 phagocytosis IEP
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0032506 cytokinetic process IMP
 biological_processGO:0051301 cell division IEA
 biological_processGO:0051592 response to calcium ion IDA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005635 nuclear envelope NAS
 cellular_componentGO:0005654 nucleoplasm NAS
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005819 spindle IEA
 cellular_componentGO:0005829 cytosol IDA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0016020 membrane HDA
 cellular_componentGO:0030496 midbody IDA
 cellular_componentGO:0042470 melanosome IEA
 cellular_componentGO:0042581 specific granule IDA
 cellular_componentGO:0042582 azurophil granule IDA
 cellular_componentGO:0045335 phagocytic vesicle IDA
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0003723 RNA binding HDA
 molecular_functionGO:0005509 calcium ion binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005544 calcium-dependent phospholipid binding IEA
 molecular_functionGO:0008429 phosphatidylethanolamine binding IEA
 molecular_functionGO:0023026 MHC class II protein complex binding HDA
 molecular_functionGO:0044548 S100 protein binding IPI
 molecular_functionGO:0048306 calcium-dependent protein binding IPI


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 HP:0000217 Xerostomia "Dryness of the mouth due to salivary gland dysfunction." [HPO:curators]
Show

 HP:0000712 Emotional lability 
Show

 HP:0000713 Agitation 
Show

 HP:0000716 Depression "A condition characterized by pervasive dysphoric mood, loss of interests, and inability to experience pleasure." [HPO:curators]
Show

 HP:0000739 Anxiety 
Show

 HP:0001257 Spasticity "A motor disorder characterized by a velocity-dependent increase in tonic stretch reflexes with increased muscle tone, exaggerated (hyperexcitable) tendon reflexes." [HPO:curators]
Show

 HP:0002017 Nausea and vomiting 
Show

 HP:0002094 Dyspnea 
Show

 HP:0002180 Neurodegeneration 
Show

 HP:0002878 Early respiratory failure 
Show

 HP:0003202 Amyotrophy "The presence of muscular atrophy (which is also known as amyotrophy)." [HPO:curators]
Show

 HP:0003324 Generalized muscle weakness "Generalized weakness or decreased strength of the muscles." [HPO:curators]
Show

 HP:0003394 Muscle cramps 
Show

 HP:0003470 Paralysis "Paralysis of voluntary muscles means loss of contraction due to interruption of one or more motor pathways from the brain to the muscle fibers. Although the word paralysis is often used interchangeably to mean either complete or partial loss of muscle strength, it is preferable to use paralysis or plegia for complete or severe loss of muscle strength, and paresis for partial or slight loss. Motor paralysis results from deficits of the upper motor neurons (corticospinal, corticobulbar, or subcorticospinal). Motor paralysis is often accompanied by an impairment in the facility of movement." [HPO:curators]
Show

 HP:0005945 Laryngeal obstruction 
Show

 HP:0007354 Amyotrophic lateral sclerosis 
Show

 HP:0012378 Fatigue "A subjective feeling of tiredness characterized by a lack of energy and motivation." [HPO:probinson]
Show

 HP:0012531 Pain "An unpleasant sensory and emotional experience associated with actual or potential tissue damage, or described in terms of such damage." [ORCID:0000-0001-5208-3432]
Show

 HP:0030195 Fatigable weakness of swallowing muscles "A type of weakness of the muscles involved in swallowing that occurs after a muscle group is used and lessens if the muscle group has some rest. That is, there is diminution of strength with repetitive muscle actions." [pmid:17986328, UK:rheller]
Show

 HP:0030196 Fatigable weakness of respiratory muscles "A type of weakness of the muscles involved in breathing (respiration) that occurs after a muscle group is used and lessens if the muscle group has some rest. That is, there is diminution of strength with repetitive muscle actions." [UNCL:mbertoli]
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   


© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr