ENSG00000135046


Homo sapiens

Features
Gene ID: ENSG00000135046
  
Biological name :ANXA1
  
Synonyms : annexin A1 / ANXA1 / P04083
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 9
Strand: 1
Band: q21.13
Gene start: 73151757
Gene end: 73170393
  
Corresponding Affymetrix probe sets: 201012_at (Human Genome U133 Plus 2.0 Array)   233011_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000257497
Ensembl peptide - ENSP00000366109
Ensembl peptide - ENSP00000412489
Ensembl peptide - ENSP00000414013
NCBI entrez gene - 301     See in Manteia.
OMIM - 151690
RefSeq - XM_017014657
RefSeq - NM_000700
RefSeq - XM_011518609
RefSeq Peptide - NP_000691
swissprot - Q5T3N0
swissprot - Q5T3N1
swissprot - Q5TZZ9
swissprot - P04083
Ensembl - ENSG00000135046
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 anxa1aENSDARG00000026726Danio rerio
 anxa1bENSDARG00000100095Danio rerio
 anxa1cENSDARG00000104359Danio rerio
 zgc:110283ENSDARG00000098481Danio rerio
 ANXA1ENSGALG00000015148Gallus gallus
 Anxa1ENSMUSG00000024659Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
ANXA2 / P07355 / annexin A2ENSG0000018271852
ANXA3 / P12429 / annexin A3ENSG0000013877245
ANXA11 / P50995 / annexin A11ENSG0000012235945
ANXA7 / P20073 / annexin A7ENSG0000013827943
ANXA4 / P09525 / annexin A4ENSG0000019697542
ANXA8 / P13928 / annexin A8ENSG0000026519041
Q5VT79 / ANXA8L1 / annexin A8 like 1ENSG0000026423041
ANXA6 / P08133 / annexin A6ENSG0000019704341
ANXA13 / P27216 / annexin A13ENSG0000010453740
ANXA5 / P08758 / annexin A5ENSG0000016411140


Protein motifs (from Interpro)
Interpro ID Name
 IPR001464  Annexin
 IPR002388  Annexin A1
 IPR018252  Annexin repeat, conserved site
 IPR018502  Annexin repeat
 IPR037104  Annexin superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000733 DNA strand renaturation IEA
 biological_processGO:0001780 neutrophil homeostasis IMP
 biological_processGO:0002250 adaptive immune response IEA
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0002548 monocyte chemotaxis IDA
 biological_processGO:0002685 regulation of leukocyte migration IEA
 biological_processGO:0006909 phagocytosis IEA
 biological_processGO:0006954 inflammatory response TAS
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007166 cell surface receptor signaling pathway IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway TAS
 biological_processGO:0007187 G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger IMP
 biological_processGO:0008360 regulation of cell shape IDA
 biological_processGO:0009725 response to hormone IEA
 biological_processGO:0010165 response to X-ray IEA
 biological_processGO:0014070 response to organic cyclic compound IEA
 biological_processGO:0014839 myoblast migration involved in skeletal muscle regeneration IEA
 biological_processGO:0018149 peptide cross-linking IDA
 biological_processGO:0019221 cytokine-mediated signaling pathway TAS
 biological_processGO:0030073 insulin secretion IEA
 biological_processGO:0030216 keratinocyte differentiation IDA
 biological_processGO:0030850 prostate gland development IEA
 biological_processGO:0031018 endocrine pancreas development IEA
 biological_processGO:0031340 positive regulation of vesicle fusion IDA
 biological_processGO:0031394 positive regulation of prostaglandin biosynthetic process IEA
 biological_processGO:0031532 actin cytoskeleton reorganization IDA
 biological_processGO:0031960 response to corticosteroid IEA
 biological_processGO:0032355 response to estradiol IEA
 biological_processGO:0032508 DNA duplex unwinding IEA
 biological_processGO:0032652 regulation of interleukin-1 production IEA
 biological_processGO:0032743 positive regulation of interleukin-2 production IDA
 biological_processGO:0033031 positive regulation of neutrophil apoptotic process IEA
 biological_processGO:0035924 cellular response to vascular endothelial growth factor stimulus IDA
 biological_processGO:0036292 DNA rewinding IEA
 biological_processGO:0042063 gliogenesis IEA
 biological_processGO:0042102 positive regulation of T cell proliferation IDA
 biological_processGO:0042127 regulation of cell proliferation IEA
 biological_processGO:0042493 response to drug IEA
 biological_processGO:0043065 positive regulation of apoptotic process IEA
 biological_processGO:0043066 negative regulation of apoptotic process TAS
 biological_processGO:0043086 negative regulation of catalytic activity IEA
 biological_processGO:0043434 response to peptide hormone IEA
 biological_processGO:0044849 estrous cycle IEA
 biological_processGO:0045087 innate immune response IEA
 biological_processGO:0045627 positive regulation of T-helper 1 cell differentiation IDA
 biological_processGO:0045629 negative regulation of T-helper 2 cell differentiation IDA
 biological_processGO:0045920 negative regulation of exocytosis IMP
 biological_processGO:0046632 alpha-beta T cell differentiation IEA
 biological_processGO:0046883 regulation of hormone secretion IMP
 biological_processGO:0050482 arachidonic acid secretion IEA
 biological_processGO:0050709 negative regulation of protein secretion IEA
 biological_processGO:0050727 regulation of inflammatory response IEA
 biological_processGO:0051384 response to glucocorticoid IEA
 biological_processGO:0070301 cellular response to hydrogen peroxide IEA
 biological_processGO:0070365 hepatocyte differentiation IEA
 biological_processGO:0070459 prolactin secretion IEA
 biological_processGO:0070555 response to interleukin-1 IEA
 biological_processGO:0071385 cellular response to glucocorticoid stimulus IDA
 biological_processGO:0071621 granulocyte chemotaxis IDA
 biological_processGO:0090050 positive regulation of cell migration involved in sprouting angiogenesis IDA
 biological_processGO:0090303 positive regulation of wound healing IDA
 biological_processGO:0097350 neutrophil clearance IMP
 biological_processGO:0098609 cell-cell adhesion IEA
 biological_processGO:1900087 positive regulation of G1/S transition of mitotic cell cycle IEA
 biological_processGO:1900138 negative regulation of phospholipase A2 activity IEA
 biological_processGO:2000483 negative regulation of interleukin-8 secretion IMP
 cellular_componentGO:0001533 cornified envelope IDA
 cellular_componentGO:0001891 phagocytic cup IEA
 cellular_componentGO:0005576 extracellular region TAS
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005654 nucleoplasm IDA
 cellular_componentGO:0005737 cytoplasm TAS
 cellular_componentGO:0005768 endosome IEA
 cellular_componentGO:0005769 early endosome IEA
 cellular_componentGO:0005829 cytosol IDA
 cellular_componentGO:0005884 actin filament IDA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005913 cell-cell adherens junction IDA
 cellular_componentGO:0005925 focal adhesion HDA
 cellular_componentGO:0005929 cilium IEA
 cellular_componentGO:0009986 cell surface IDA
 cellular_componentGO:0010008 endosome membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016323 basolateral plasma membrane IEA
 cellular_componentGO:0016324 apical plasma membrane ISS
 cellular_componentGO:0016328 lateral plasma membrane ISS
 cellular_componentGO:0019898 extrinsic component of membrane IDA
 cellular_componentGO:0030659 cytoplasmic vesicle membrane IEA
 cellular_componentGO:0031232 extrinsic component of external side of plasma membrane IDA
 cellular_componentGO:0031313 extrinsic component of endosome membrane ISS
 cellular_componentGO:0031410 cytoplasmic vesicle IEA
 cellular_componentGO:0031514 motile cilium IEA
 cellular_componentGO:0031901 early endosome membrane ISS
 cellular_componentGO:0031966 mitochondrial membrane IEA
 cellular_componentGO:0031982 vesicle HDA
 cellular_componentGO:0042383 sarcolemma IEA
 cellular_componentGO:0042629 mast cell granule IEA
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0070062 extracellular exosome IEA
 molecular_functionGO:0003697 single-stranded DNA binding IEA
 molecular_functionGO:0003727 single-stranded RNA binding IEA
 molecular_functionGO:0004386 helicase activity IEA
 molecular_functionGO:0004859 phospholipase inhibitor activity IEA
 molecular_functionGO:0005102 signaling receptor binding TAS
 molecular_functionGO:0005198 structural molecule activity IDA
 molecular_functionGO:0005509 calcium ion binding TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005543 phospholipid binding IEA
 molecular_functionGO:0005544 calcium-dependent phospholipid binding IDA
 molecular_functionGO:0019834 phospholipase A2 inhibitor activity IEA
 molecular_functionGO:0030674 protein binding, bridging IDA
 molecular_functionGO:0033676 double-stranded DNA-dependent ATPase activity IEA
 molecular_functionGO:0036310 annealing helicase activity IEA
 molecular_functionGO:0042803 protein homodimerization activity IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0048306 calcium-dependent protein binding IPI
 molecular_functionGO:0098641 cadherin binding involved in cell-cell adhesion IDA


Pathways (from Reactome)
Pathway description
G alpha (q) signalling events
G alpha (i) signalling events
Formyl peptide receptors bind formyl peptides and many other ligands
Smooth Muscle Contraction
Interleukin-4 and Interleukin-13 signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000187474 FPR3 / P25089 / formyl peptide receptor 3  / reaction / complex
 ENSG00000182718 ANXA2 / P07355 / annexin A2  / reaction
 ENSG00000135636 DYSF / O75923 / dysferlin  / reaction
 ENSG00000182533 CAV3 / P56539 / caveolin 3  / reaction
 ENSG00000177238 Q6ZMU5 / TRIM72 / tripartite motif containing 72  / reaction
 ENSG00000197043 ANXA6 / P08133 / annexin A6  / reaction






 

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