ENSG00000187474


Homo sapiens

Features
Gene ID: ENSG00000187474
  
Biological name :FPR3
  
Synonyms : formyl peptide receptor 3 / FPR3 / P25089
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 19
Strand: 1
Band: q13.41
Gene start: 51795163
Gene end: 51826189
  
Corresponding Affymetrix probe sets: 214560_at (Human Genome U133 Plus 2.0 Array)   230422_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000341821
Ensembl peptide - ENSP00000470471
NCBI entrez gene - 2359     See in Manteia.
OMIM - 136539
RefSeq - XM_011526687
RefSeq - NM_002030
RefSeq Peptide - NP_002021
swissprot - P25089
swissprot - Q6L5J4
Ensembl - ENSG00000187474
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 A4FUQ5ENSMUSG00000048062Mus musculus
 O88537ENSMUSG00000060701Mus musculus
 Q3SXG2ENSMUSG00000071275Mus musculus
 Q71MR7ENSMUSG00000071276Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
FPR2 / P25090 / formyl peptide receptor 2ENSG0000017104972
FPR1 / P21462 / formyl peptide receptor 1ENSG0000017105158
CMKLR1 / Q99788 / chemerin chemokine-like receptor 1ENSG0000017460033
PTGDR2 / Q9Y5Y4 / prostaglandin D2 receptor 2ENSG0000018313432
GPR32 / O75388 / G protein-coupled receptor 32ENSG0000014251131
C3AR1 / Q16581 / complement C3a receptor 1ENSG0000017186031
C5AR1 / P21730 / complement C5a receptor 1ENSG0000019740530
GPR1 / P46091 / G protein-coupled receptor 1ENSG0000018367130
GPR33 / Q49SQ1 / G protein-coupled receptor 33 (gene/pseudogene)ENSG0000021494329
C5AR2 / Q9P296 / complement component 5a receptor 2ENSG0000013483024
GPR152 / Q8TDT2 / G protein-coupled receptor 152ENSG0000017551422


Protein motifs (from Interpro)
Interpro ID Name
 IPR000276  G protein-coupled receptor, rhodopsin-like
 IPR000826  Formyl peptide receptor-related
 IPR017452  GPCR, rhodopsin-like, 7TM
 IPR027347  Formyl peptide receptor 2/3


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002430 complement receptor mediated signaling pathway IBA
 biological_processGO:0006935 chemotaxis IEA
 biological_processGO:0006954 inflammatory response IBA
 biological_processGO:0007165 signal transduction TAS
 biological_processGO:0007186 G-protein coupled receptor signaling pathway TAS
 biological_processGO:0007200 phospholipase C-activating G-protein coupled receptor signaling pathway IBA
 biological_processGO:0007204 positive regulation of cytosolic calcium ion concentration IBA
 biological_processGO:0050900 leukocyte migration IBA
 biological_processGO:0060326 cell chemotaxis IBA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0005887 integral component of plasma membrane IBA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane TAS
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0004875 complement receptor activity IBA
 molecular_functionGO:0004930 G-protein coupled receptor activity IEA
 molecular_functionGO:0004982 N-formyl peptide receptor activity TAS


Pathways (from Reactome)
Pathway description
G alpha (i) signalling events
Formyl peptide receptors bind formyl peptides and many other ligands


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000013583 HEBP1 / Q9NRV9 / heme binding protein 1  / reaction / complex
 ENSG00000135046 ANXA1 / P04083 / annexin A1  / complex / reaction






 

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