ENSG00000171049


Homo sapiens

Features
Gene ID: ENSG00000171049
  
Biological name :FPR2
  
Synonyms : formyl peptide receptor 2 / FPR2 / P25090
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 19
Strand: 1
Band: q13.41
Gene start: 51752026
Gene end: 51770526
  
Corresponding Affymetrix probe sets: 210772_at (Human Genome U133 Plus 2.0 Array)   210773_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000470373
Ensembl peptide - ENSP00000469085
Ensembl peptide - ENSP00000472259
Ensembl peptide - ENSP00000340191
Ensembl peptide - ENSP00000468876
Ensembl peptide - ENSP00000468897
NCBI entrez gene - 2358     See in Manteia.
OMIM - 136538
RefSeq - XM_017026542
RefSeq - NM_001005738
RefSeq - NM_001462
RefSeq - XM_006723120
RefSeq Peptide - NP_001453
RefSeq Peptide - NP_001005738
swissprot - M0R222
swissprot - P25090
swissprot - M0QXD3
swissprot - M0QZ89
swissprot - A0A024R4P3
Ensembl - ENSG00000171049
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 Fpr2ENSMUSG00000052270Mus musculus
 Fpr3ENSMUSG00000079700Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
FPR3 / P25089 / formyl peptide receptor 3ENSG0000018747473
FPR1 / P21462 / formyl peptide receptor 1ENSG0000017105169
C3AR1 / Q16581 / complement C3a receptor 1ENSG0000017186034
CMKLR1 / Q99788 / chemerin chemokine-like receptor 1ENSG0000017460033
PTGDR2 / Q9Y5Y4 / prostaglandin D2 receptor 2ENSG0000018313432
GPR32 / O75388 / G protein-coupled receptor 32ENSG0000014251132
GPR1 / P46091 / G protein-coupled receptor 1ENSG0000018367131
C5AR1 / P21730 / complement C5a receptor 1ENSG0000019740530
GPR33 / Q49SQ1 / G protein-coupled receptor 33 (gene/pseudogene)ENSG0000021494329
C5AR2 / Q9P296 / complement component 5a receptor 2ENSG0000013483025
GPR152 / Q8TDT2 / G protein-coupled receptor 152ENSG0000017551425


Protein motifs (from Interpro)
Interpro ID Name
 IPR000276  G protein-coupled receptor, rhodopsin-like
 IPR000826  Formyl peptide receptor-related
 IPR017452  GPCR, rhodopsin-like, 7TM
 IPR027347  Formyl peptide receptor 2/3


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001774 microglial cell activation ISS
 biological_processGO:0001934 positive regulation of protein phosphorylation IGI
 biological_processGO:0002430 complement receptor mediated signaling pathway IBA
 biological_processGO:0006898 receptor-mediated endocytosis ISS
 biological_processGO:0006935 chemotaxis TAS
 biological_processGO:0006954 inflammatory response TAS
 biological_processGO:0007155 cell adhesion TAS
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway IEA
 biological_processGO:0007193 adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway ISS
 biological_processGO:0007200 phospholipase C-activating G-protein coupled receptor signaling pathway IBA
 biological_processGO:0007204 positive regulation of cytosolic calcium ion concentration IBA
 biological_processGO:0019722 calcium-mediated signaling IGI
 biological_processGO:0032930 positive regulation of superoxide anion generation ISS
 biological_processGO:0043312 neutrophil degranulation TAS
 biological_processGO:0048143 astrocyte activation ISS
 biological_processGO:0050900 leukocyte migration IBA
 biological_processGO:0050918 positive chemotaxis ISS
 biological_processGO:0060326 cell chemotaxis IBA
 biological_processGO:0061903 positive regulation of 1-phosphatidylinositol-3-kinase activity ISS
 biological_processGO:0070374 positive regulation of ERK1 and ERK2 cascade ISS
 biological_processGO:0090026 positive regulation of monocyte chemotaxis IGI
 biological_processGO:1904646 cellular response to amyloid-beta ISS
 cellular_componentGO:0005622 intracellular ISS
 cellular_componentGO:0005737 cytoplasm ISS
 cellular_componentGO:0005886 plasma membrane ISS
 cellular_componentGO:0005887 integral component of plasma membrane IBA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0035579 specific granule membrane TAS
 cellular_componentGO:0070821 tertiary granule membrane TAS
 cellular_componentGO:0101003 ficolin-1-rich granule membrane TAS
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0004875 complement receptor activity IBA
 molecular_functionGO:0004930 G-protein coupled receptor activity IEA
 molecular_functionGO:0004982 N-formyl peptide receptor activity IEA
 molecular_functionGO:0005124 scavenger receptor binding IPI
 molecular_functionGO:0038024 cargo receptor activity ISS


Pathways (from Reactome)
Pathway description
G alpha (q) signalling events
G alpha (i) signalling events
Formyl peptide receptors bind formyl peptides and many other ligands
Neutrophil degranulation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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