ENSG00000197405


Homo sapiens

Features
Gene ID: ENSG00000197405
  
Biological name :C5AR1
  
Synonyms : C5AR1 / complement C5a receptor 1 / P21730
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 19
Strand: 1
Band: q13.32
Gene start: 47290023
Gene end: 47322066
  
Corresponding Affymetrix probe sets: 220088_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000347197
Ensembl peptide - ENSP00000470613
NCBI entrez gene - 728     See in Manteia.
OMIM - 113995
RefSeq - XM_005259190
RefSeq - NM_001736
RefSeq Peptide - NP_001727
swissprot - P21730
swissprot - M0QZK7
Ensembl - ENSG00000197405
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 P0C7U5ENSDARG00000040319Danio rerio
 C5ar1ENSMUSG00000049130Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
C5AR2 / Q9P296 / complement component 5a receptor 2ENSG0000013483036
C3AR1 / Q16581 / complement C3a receptor 1ENSG0000017186035
CMKLR1 / Q99788 / chemerin chemokine-like receptor 1ENSG0000017460031
FPR3 / P25089 / formyl peptide receptor 3ENSG0000018747430
FPR2 / P25090 / formyl peptide receptor 2ENSG0000017104930
FPR1 / P21462 / formyl peptide receptor 1ENSG0000017105129
GPR1 / P46091 / G protein-coupled receptor 1ENSG0000018367127
PTGDR2 / Q9Y5Y4 / prostaglandin D2 receptor 2ENSG0000018313425
GPR33 / Q49SQ1 / G protein-coupled receptor 33 (gene/pseudogene)ENSG0000021494325
GPR32 / O75388 / G protein-coupled receptor 32ENSG0000014251125
GPR152 / Q8TDT2 / G protein-coupled receptor 152ENSG0000017551421


Protein motifs (from Interpro)
Interpro ID Name
 IPR000276  G protein-coupled receptor, rhodopsin-like
 IPR000826  Formyl peptide receptor-related
 IPR001274  C5a1/C5a2 anaphylatoxin chemotactic receptor
 IPR002234  Anaphylatoxin chemotactic receptor family
 IPR017452  GPCR, rhodopsin-like, 7TM


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000187 activation of MAPK activity TAS
 biological_processGO:0002430 complement receptor mediated signaling pathway IEA
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0006935 chemotaxis TAS
 biological_processGO:0006954 inflammatory response IEA
 biological_processGO:0006955 immune response TAS
 biological_processGO:0006968 cellular defense response TAS
 biological_processGO:0007165 signal transduction TAS
 biological_processGO:0007186 G-protein coupled receptor signaling pathway TAS
 biological_processGO:0007200 phospholipase C-activating G-protein coupled receptor signaling pathway IBA
 biological_processGO:0007202 activation of phospholipase C activity TAS
 biological_processGO:0007204 positive regulation of cytosolic calcium ion concentration IEA
 biological_processGO:0007606 sensory perception of chemical stimulus TAS
 biological_processGO:0010575 positive regulation of vascular endothelial growth factor production IEA
 biological_processGO:0010759 positive regulation of macrophage chemotaxis IEA
 biological_processGO:0021534 cell proliferation in hindbrain IEA
 biological_processGO:0030449 regulation of complement activation TAS
 biological_processGO:0030593 neutrophil chemotaxis IEA
 biological_processGO:0031100 animal organ regeneration IEA
 biological_processGO:0032494 response to peptidoglycan IEA
 biological_processGO:0032496 response to lipopolysaccharide IEA
 biological_processGO:0038178 complement component C5a signaling pathway IEA
 biological_processGO:0042789 mRNA transcription by RNA polymerase II IDA
 biological_processGO:0043312 neutrophil degranulation TAS
 biological_processGO:0043524 negative regulation of neuron apoptotic process IEA
 biological_processGO:0045766 positive regulation of angiogenesis IEA
 biological_processGO:0050679 positive regulation of epithelial cell proliferation IDA
 biological_processGO:0050830 defense response to Gram-positive bacterium IEA
 biological_processGO:0050900 leukocyte migration IBA
 biological_processGO:0060326 cell chemotaxis IBA
 biological_processGO:0070374 positive regulation of ERK1 and ERK2 cascade IDA
 biological_processGO:0090023 positive regulation of neutrophil chemotaxis IEA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0005887 integral component of plasma membrane TAS
 cellular_componentGO:0009986 cell surface IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0016323 basolateral plasma membrane IDA
 cellular_componentGO:0030667 secretory granule membrane TAS
 cellular_componentGO:0031410 cytoplasmic vesicle IEA
 cellular_componentGO:0045177 apical part of cell IDA
 molecular_functionGO:0001856 complement component C5a binding IEA
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0004875 complement receptor activity IEA
 molecular_functionGO:0004878 complement component C5a receptor activity IDA
 molecular_functionGO:0004930 G-protein coupled receptor activity IBA


Pathways (from Reactome)
Pathway description
Peptide ligand-binding receptors
G alpha (i) signalling events
Neutrophil degranulation
Regulation of Complement cascade


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000106804 C5 / P01031 / complement C5  / complex / reaction






 

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