ENSG00000134830


Homo sapiens

Features
Gene ID: ENSG00000134830
  
Biological name :C5AR2
  
Synonyms : C5AR2 / complement component 5a receptor 2 / Q9P296
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 19
Strand: 1
Band: q13.32
Gene start: 47332147
Gene end: 47347327
  
Corresponding Affymetrix probe sets: 221149_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000471184
Ensembl peptide - ENSP00000472620
NCBI entrez gene - 27202     See in Manteia.
OMIM - 609949
RefSeq - XM_011526736
RefSeq - NM_001271749
RefSeq - NM_001271750
RefSeq - NM_018485
RefSeq Peptide - NP_001258679
RefSeq Peptide - NP_060955
RefSeq Peptide - NP_001258678
swissprot - Q9P296
Ensembl - ENSG00000134830
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 P0C7U5ENSDARG00000040319Danio rerio
 C5ar2ENSMUSG00000074361Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
C5AR1 / P21730 / complement C5a receptor 1ENSG0000019740537
C3AR1 / Q16581 / complement C3a receptor 1ENSG0000017186031
PTGDR2 / Q9Y5Y4 / prostaglandin D2 receptor 2ENSG0000018313428
CMKLR1 / Q99788 / chemerin chemokine-like receptor 1ENSG0000017460027
FPR1 / P21462 / formyl peptide receptor 1ENSG0000017105126
FPR2 / P25090 / formyl peptide receptor 2ENSG0000017104926
GPR1 / P46091 / G protein-coupled receptor 1ENSG0000018367126
FPR3 / P25089 / formyl peptide receptor 3ENSG0000018747425
GPR152 / Q8TDT2 / G protein-coupled receptor 152ENSG0000017551425
GPR32 / O75388 / G protein-coupled receptor 32ENSG0000014251123
GPR33 / Q49SQ1 / G protein-coupled receptor 33 (gene/pseudogene)ENSG0000021494320


Protein motifs (from Interpro)
Interpro ID Name
 IPR000276  G protein-coupled receptor, rhodopsin-like
 IPR000826  Formyl peptide receptor-related
 IPR001274  C5a1/C5a2 anaphylatoxin chemotactic receptor
 IPR017452  GPCR, rhodopsin-like, 7TM
 IPR027809  C5a anaphylatoxin chemotactic receptor 2


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006935 chemotaxis IEA
 biological_processGO:0006954 inflammatory response IBA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway IEA
 biological_processGO:0007200 phospholipase C-activating G-protein coupled receptor signaling pathway IBA
 biological_processGO:0007204 positive regulation of cytosolic calcium ion concentration IBA
 biological_processGO:0030449 regulation of complement activation TAS
 biological_processGO:0032720 negative regulation of tumor necrosis factor production IMP
 biological_processGO:0038178 complement component C5a signaling pathway IEA
 biological_processGO:0050679 positive regulation of epithelial cell proliferation IEA
 biological_processGO:0070374 positive regulation of ERK1 and ERK2 cascade IEA
 biological_processGO:0090024 negative regulation of neutrophil chemotaxis IMP
 biological_processGO:1900165 negative regulation of interleukin-6 secretion IMP
 biological_processGO:2000482 regulation of interleukin-8 secretion IMP
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0005887 integral component of plasma membrane IBA
 cellular_componentGO:0009925 basal plasma membrane IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0045177 apical part of cell IDA
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0004878 complement component C5a receptor activity IBA
 molecular_functionGO:0004930 G-protein coupled receptor activity IBA
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
Peptide ligand-binding receptors
Regulation of Complement cascade


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000106804 C5 / P01031 / complement C5  / reaction / complex






 

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