ENSMUSG00000074361


Mus musculus

Features
Gene ID: ENSMUSG00000074361
  
Biological name :C5ar2
  
Synonyms : C5ar2 / complement component 5a receptor 2
  
Possible biological names infered from orthology : Q9P296
  
Species: Mus musculus
  
Chr. number: 7
Strand: -1
Band: A2
Gene start: 16234585
Gene end: 16244154
  
Corresponding Affymetrix probe sets: 10560237 (MoGene1.0st)   
  
Cross references: Ensembl peptide - ENSMUSP00000096389
Ensembl peptide - ENSMUSP00000133056
NCBI entrez gene - 319430     See in Manteia.
MGI - MGI:2442013
RefSeq - NM_001146005
RefSeq - NM_176912
RefSeq Peptide - NP_001139477
RefSeq Peptide - NP_795886
swissprot - E9QQ21
swissprot - E9PVQ2
Ensembl - ENSMUSG00000074361
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 P0C7U5ENSDARG00000040319Danio rerio
 C5AR2ENSG00000134830Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
C5ar1 / P30993 / C5a anaphylatoxin chemotactic receptor 1 / P21730* / complement C5a receptor 1*ENSMUSG0000004913034
C3ar1 / O09047 / C3a anaphylatoxin chemotactic receptor / Q16581* / complement C3a receptor 1*ENSMUSG0000004055229
Gpr1 / Q8K087 / G-protein coupled receptor 1 / P46091*ENSMUSG0000004685624
Ptgdr2 / Q9Z2J6 / Prostaglandin D2 receptor 2 / Q9Y5Y4*ENSMUSG0000003411723
Q71MR7 / Fpr-rs7 / Formyl peptide receptor-related sequence 7 / FPR3* / P25089* / formyl peptide receptor 3*ENSMUSG0000007127622
Cmklr1 / P97468 / Mus musculus chemokine-like receptor 1 (Cmklr1), transcript variant 1, mRNA. / Q99788* / chemerin chemokine-like receptor 1*ENSMUSG0000004219022
Fpr2 / O88536 / Formyl peptide receptor 2 / P25090*ENSMUSG0000005227022
A4FUQ5 / Fpr-rs4 / Formyl peptide receptor-related sequence 4 / FPR3* / P25089* / formyl peptide receptor 3*ENSMUSG0000004806222
O88537 / Fpr-rs3 / Formyl peptide receptor-related sequence 3 / FPR3* / P25089* / formyl peptide receptor 3*ENSMUSG0000006070122
Fpr3 / O08790 / Formyl peptide receptor-related sequence 1 / FPR2* / P25090* / formyl peptide receptor 2*ENSMUSG0000007970022
Fpr1 / P33766 / fMet-Leu-Phe receptor / P21462* / formyl peptide receptor 1*ENSMUSG0000004555122
Q3SXG2 / Fpr-rs6 / Formyl peptide receptor-related sequence 6 / FPR3* / P25089* / formyl peptide receptor 3*ENSMUSG0000007127521
Gpr33 / O88416 / Probable G-protein coupled receptor 33 / Q49SQ1* / G protein-coupled receptor 33 (gene/pseudogene)*ENSMUSG0000003514820
Gpr152 / Q8BXS7 / G protein-coupled receptor 152 / Q8TDT2*ENSMUSG0000004472420


Protein motifs (from Interpro)
Interpro ID Name
 IPR000276  G protein-coupled receptor, rhodopsin-like
 IPR000826  Formyl peptide receptor-related
 IPR001274  C5a1/C5a2 anaphylatoxin chemotactic receptor
 IPR017452  GPCR, rhodopsin-like, 7TM
 IPR027809  C5a anaphylatoxin chemotactic receptor 2


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006935 chemotaxis IEA
 biological_processGO:0006954 inflammatory response IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway IEA
 biological_processGO:0032720 negative regulation of tumor necrosis factor production IEA
 biological_processGO:0038178 complement component C5a signaling pathway IEA
 biological_processGO:0050679 positive regulation of epithelial cell proliferation IEA
 biological_processGO:0070374 positive regulation of ERK1 and ERK2 cascade IEA
 biological_processGO:0090024 negative regulation of neutrophil chemotaxis IEA
 biological_processGO:1900165 negative regulation of interleukin-6 secretion IEA
 biological_processGO:2000482 regulation of interleukin-8 secretion IEA
 cellular_componentGO:0009925 basal plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0045177 apical part of cell IEA
 molecular_functionGO:0004878 complement component C5a receptor activity IEA
 molecular_functionGO:0004930 G-protein coupled receptor activity IEA


Pathways (from Reactome)
Pathway description
Peptide ligand-binding receptors
Regulation of Complement cascade


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000598 abnormal liver morphology "malformation or absence of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:23170]
Show

Allelic Composition: Nmur2tm1Rtor/Nmur2tm1Rtor
Genetic Background: involves: 129S1/Sv * C57BL/6NTac

 MP:0001656 focal hepatic necrosis "a localized area of pathologic death of cells within, or a portion of, the liver" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Nmur2tm1Rtor/Nmur2tm1Rtor
Genetic Background: involves: 129S1/Sv * C57BL/6NTac

 MP:0001657 abnormal induced morbidity/mortality "differences from the expected diseased state or death caused by an external intervention" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Nmur2tm1Rtor/Nmur2tm1Rtor
Genetic Background: involves: 129S1/Sv * C57BL/6NTac

 MP:0001819 abnormal immune cell physiology "abnormal function of the cells of the immune system" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Hhiptm1Amc/Hhiptm1Amc,Ptch1tm1Mps/Ptch1tm1Mps,Tg(Mt1-Ptch1)MT22Mps/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB

 MP:0001846 increased inflammatory response "greater than expected response to injury, infection, or insult " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Hhiptm1Amc/Hhiptm1Amc,Ptch1tm1Mps/Ptch1tm1Mps,Tg(Mt1-Ptch1)MT22Mps/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB

 MP:0002078 abnormal glucose homeostasis "anomaly in the state of equilibrium or processing in the body with respect to glucose in the fluids and tissues" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Nmur2tm1Rtor/Nmur2tm1Rtor
Genetic Background: involves: 129S1/Sv * C57BL/6NTac

 MP:0002079 increased circulating insulin level "greater than normal levels of insulin in blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Nmur2tm1Rtor/Nmur2tm1Rtor
Genetic Background: involves: 129S1/Sv * C57BL/6NTac

 MP:0002628 fatty liver "an accumulation of fat deposits in the liver " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Nmur2tm1Rtor/Nmur2tm1Rtor
Genetic Background: involves: 129S1/Sv * C57BL/6NTac

 MP:0002941 increased circulating alanine transaminase level "increased concentration in the blood of this enzyme, which transfers amino groups from l-alanine to 2 ketoglutarate, or the reverse (from l-glutamate to pyruvate); serum concentration is increased in viral hepatitis and myocardial infarction" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Nmur2tm1Rtor/Nmur2tm1Rtor
Genetic Background: involves: 129S1/Sv * C57BL/6NTac

 MP:0005344 increased circulating bilirubin level "greater than the normal concentration in the blood of this yellow heme breakdown product" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:85204]
Show

Allelic Composition: Nmur2tm1Rtor/Nmur2tm1Rtor
Genetic Background: involves: 129S1/Sv * C57BL/6NTac

 MP:0005666 abnormal adipose tissue physiology "functional anomaly of the connective tissue composed of fat cells enmeshed in areolar tissue" [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings, 2003]
Show

Allelic Composition: Nmur2tm1Rtor/Nmur2tm1Rtor
Genetic Background: involves: 129S1/Sv * C57BL/6NTac

 MP:0009115 abnormal fat cell morphology "any structural anomaly of a fat-storing cell found mostly in the abdominal cavity and subcutaneous tissue of mammals" [CL:0000449]
Show

Allelic Composition: Nmur2tm1Rtor/Nmur2tm1Rtor
Genetic Background: involves: 129S1/Sv * C57BL/6NTac

 MP:0010954 abnormal cellular respiration "anomaly in the enzymatic release of energy from organic compounds (especially carbohydrates and fats) which either requires oxygen (aerobic respiration) or does not (anaerobic respiration)" [GO:0045333]
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Allelic Composition: Nmur2tm1Rtor/Nmur2tm1Rtor
Genetic Background: involves: 129S1/Sv * C57BL/6NTac

 MP:0011939 increased food intake "increase in the total number of calories/food amount taken in over time when compared to the normal state" [MGI:csmith]
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Allelic Composition: Nmur2tm1Rtor/Nmur2tm1Rtor
Genetic Background: involves: 129S1/Sv * C57BL/6NTac

 MP:0014171 increased fatty acid oxidation "increased rate or incidence of the process of removal of one or more electrons from a fatty acid, with or without the concomitant removal of a proton or protons, by reaction with an electron-accepting substance, by addition of oxygen or by removal of hydrogen" [GO:0019395]
Show

Allelic Composition: Nmur2tm1Rtor/Nmur2tm1Rtor
Genetic Background: involves: 129S1/Sv * C57BL/6NTac

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000026874 Hc / P06684 / hemolytic complement / C5* / P01031* / complement C5*  / reaction / complex






 

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