ENSMUSG00000049130


Mus musculus

Features
Gene ID: ENSMUSG00000049130
  
Biological name :C5ar1
  
Synonyms : C5a anaphylatoxin chemotactic receptor 1 / C5ar1 / P30993
  
Possible biological names infered from orthology : complement C5a receptor 1 / P21730
  
Species: Mus musculus
  
Chr. number: 7
Strand: -1
Band: A2
Gene start: 16246743
Gene end: 16259540
  
Corresponding Affymetrix probe sets: 10560242 (MoGene1.0st)   1422190_at (Mouse Genome 430 2.0 Array)   1439902_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000148140
Ensembl peptide - ENSMUSP00000060003
Ensembl peptide - ENSMUSP00000129972
NCBI entrez gene - 12273     See in Manteia.
MGI - MGI:88232
RefSeq - NM_001173550
RefSeq - NM_007577
RefSeq Peptide - NP_001167021
RefSeq Peptide - NP_031603
swissprot - A0A1B0GT01
swissprot - P30993
Ensembl - ENSMUSG00000049130
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 P0C7U5ENSDARG00000040319Danio rerio
 C5AR1ENSG00000197405Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
C5ar2 / complement component 5a receptor 2 / Q9P296*ENSMUSG0000007436135
C3ar1 / O09047 / C3a anaphylatoxin chemotactic receptor / Q16581* / complement C3a receptor 1*ENSMUSG0000004055232
Fpr3 / O08790 / Formyl peptide receptor-related sequence 1 / FPR2* / P25090* / formyl peptide receptor 2*ENSMUSG0000007970029
Cmklr1 / P97468 / Mus musculus chemokine-like receptor 1 (Cmklr1), transcript variant 1, mRNA. / Q99788* / chemerin chemokine-like receptor 1*ENSMUSG0000004219028
Fpr2 / O88536 / Formyl peptide receptor 2 / P25090*ENSMUSG0000005227028
Fpr1 / P33766 / fMet-Leu-Phe receptor / P21462* / formyl peptide receptor 1*ENSMUSG0000004555128
O88537 / Fpr-rs3 / Formyl peptide receptor-related sequence 3 / FPR3* / P25089* / formyl peptide receptor 3*ENSMUSG0000006070126
Q3SXG2 / Fpr-rs6 / Formyl peptide receptor-related sequence 6 / FPR3* / P25089* / formyl peptide receptor 3*ENSMUSG0000007127526
Q71MR7 / Fpr-rs7 / Formyl peptide receptor-related sequence 7 / FPR3* / P25089* / formyl peptide receptor 3*ENSMUSG0000007127626
Gpr33 / O88416 / Probable G-protein coupled receptor 33 / Q49SQ1* / G protein-coupled receptor 33 (gene/pseudogene)*ENSMUSG0000003514825
Gpr1 / Q8K087 / G-protein coupled receptor 1 / P46091*ENSMUSG0000004685625
A4FUQ5 / Fpr-rs4 / Formyl peptide receptor-related sequence 4 / FPR3* / P25089* / formyl peptide receptor 3*ENSMUSG0000004806225
Ptgdr2 / Q9Z2J6 / Prostaglandin D2 receptor 2 / Q9Y5Y4*ENSMUSG0000003411724
Gpr152 / Q8BXS7 / G protein-coupled receptor 152 / Q8TDT2*ENSMUSG0000004472419


Protein motifs (from Interpro)
Interpro ID Name
 IPR000276  G protein-coupled receptor, rhodopsin-like
 IPR000826  Formyl peptide receptor-related
 IPR001274  C5a1/C5a2 anaphylatoxin chemotactic receptor
 IPR002234  Anaphylatoxin chemotactic receptor family
 IPR017452  GPCR, rhodopsin-like, 7TM


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002430 complement receptor mediated signaling pathway IEA
 biological_processGO:0006935 chemotaxis IEA
 biological_processGO:0006954 inflammatory response IBA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway IEA
 biological_processGO:0007200 phospholipase C-activating G-protein coupled receptor signaling pathway IBA
 biological_processGO:0007204 positive regulation of cytosolic calcium ion concentration IBA
 biological_processGO:0010575 positive regulation of vascular endothelial growth factor production IMP
 biological_processGO:0010759 positive regulation of macrophage chemotaxis IMP
 biological_processGO:0030593 neutrophil chemotaxis IMP
 biological_processGO:0032494 response to peptidoglycan IMP
 biological_processGO:0038178 complement component C5a signaling pathway IEA
 biological_processGO:0042789 mRNA transcription by RNA polymerase II ISS
 biological_processGO:0045766 positive regulation of angiogenesis IMP
 biological_processGO:0050679 positive regulation of epithelial cell proliferation ISO
 biological_processGO:0050830 defense response to Gram-positive bacterium IMP
 biological_processGO:0070374 positive regulation of ERK1 and ERK2 cascade ISS
 biological_processGO:0090023 positive regulation of neutrophil chemotaxis IMP
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005887 integral component of plasma membrane IBA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0016323 basolateral plasma membrane ISS
 cellular_componentGO:0031410 cytoplasmic vesicle IEA
 cellular_componentGO:0045177 apical part of cell ISO
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0004875 complement receptor activity IEA
 molecular_functionGO:0004878 complement component C5a receptor activity ISO
 molecular_functionGO:0004930 G-protein coupled receptor activity IBA


Pathways (from Reactome)
Pathway description
Peptide ligand-binding receptors
G alpha (i) signalling events
Neutrophil degranulation
Regulation of Complement cascade


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001800 abnormal humoral immune response "abnormal immune function mediated by antibodies" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Juntm1Wag/Juntm1Wag,Tg(Junb)1598Angl/0
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0002412 increased susceptibility to bacterial infection "greater likelihood that an organism will develop ill effects from a bacterial infection or from components of or toxins produced by bacteria" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Juntm1Wag/Juntm1Wag,Tg(Junb)1598Angl/0
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0002463 abnormal neutrophil physiology "abnormal function of these granular leukocytes, which stain with neutral dyes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Sox9tm1Gsr/Sox9tm1Gsr,Tg(Col2a1/Acan-rtTA,tetO-cre)#Vlf/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0004985 decreased osteoclast cell number "reduced number of the bone resorpting cells that remove bone tissue by degrading the mineralized matrix" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Frem1bat/Frem1+
Genetic Background: C57BL/6J-Frem1bat

 MP:0008481 increased spleen germinal center number "greater number of spleen secondary B follicles where rapid B-cell proliferation, somatic hypermutation, and selection for antigen binding occurs" [PMID:17495967]
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Allelic Composition: GckRgsc960/Gck+
Genetic Background: involves: C57BL/6JJcl * DBA/2JJcl

 MP:0008597 decreased circulating interleukin-6 level "reduction in the amount in the blood of a cytokine that stimulates the growth and differentiation of B-cells and is also a growth factor for hybridomas and plasmacytomas, and is produced by many different cells including T-cells, monocytes and fibroblasts" [MESH:D12.644.276.374.465.506]
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Allelic Composition: Frem1bat/Frem1+
Genetic Background: C57BL/6J-Frem1bat

 MP:0008719 impaired neutrophil recruitment "reduced diffusion or accumulation of neutrophils in tissues or cells in response to a wide variety of substances released at the sites of inflammatory reactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Juntm1Wag/Juntm1Wag,Tg(Junb)1598Angl/0
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0009763 increased sensitivity to induced morbidity/mortality "decrease in the amount of an external agent required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Juntm1Wag/Juntm1Wag,Tg(Junb)1598Angl/0
Genetic Background: involves: 129S2/SvPas * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000026874 Hc / P06684 / hemolytic complement / C5* / P01031* / complement C5*  / reaction / complex






 

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