ENSMUSG00000052270


Mus musculus

Features
Gene ID: ENSMUSG00000052270
  
Biological name :Fpr2
  
Synonyms : Formyl peptide receptor 2 / Fpr2 / O88536
  
Possible biological names infered from orthology : P25090
  
Species: Mus musculus
  
Chr. number: 17
Strand: 1
Band: A3.2
Gene start: 17887824
Gene end: 17893952
  
Corresponding Affymetrix probe sets: 1422953_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000065799
Ensembl peptide - ENSMUSP00000153922
NCBI entrez gene - 14289     See in Manteia.
MGI - MGI:1278319
RefSeq - NM_008039
RefSeq Peptide - NP_032065
swissprot - O88536
Ensembl - ENSMUSG00000052270
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 FPR2ENSG00000171049Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Fpr3 / O08790 / Formyl peptide receptor-related sequence 1 / FPR2* / P25090* / formyl peptide receptor 2*ENSMUSG0000007970081
O88537 / Fpr-rs3 / Formyl peptide receptor-related sequence 3 / FPR3* / P25089* / formyl peptide receptor 3*ENSMUSG0000006070166
A4FUQ5 / Fpr-rs4 / Formyl peptide receptor-related sequence 4 / FPR3* / P25089* / formyl peptide receptor 3*ENSMUSG0000004806264
Fpr1 / P33766 / fMet-Leu-Phe receptor / P21462* / formyl peptide receptor 1*ENSMUSG0000004555161
Q71MR7 / Fpr-rs7 / Formyl peptide receptor-related sequence 7 / FPR3* / P25089* / formyl peptide receptor 3*ENSMUSG0000007127660
Q3SXG2 / Fpr-rs6 / Formyl peptide receptor-related sequence 6 / FPR3* / P25089* / formyl peptide receptor 3*ENSMUSG0000007127559
Cmklr1 / P97468 / Mus musculus chemokine-like receptor 1 (Cmklr1), transcript variant 1, mRNA. / Q99788* / chemerin chemokine-like receptor 1*ENSMUSG0000004219034
C3ar1 / O09047 / C3a anaphylatoxin chemotactic receptor / Q16581* / complement C3a receptor 1*ENSMUSG0000004055233
Gpr1 / Q8K087 / G-protein coupled receptor 1 / P46091*ENSMUSG0000004685630
Ptgdr2 / Q9Z2J6 / Prostaglandin D2 receptor 2 / Q9Y5Y4*ENSMUSG0000003411730
Gpr33 / O88416 / Probable G-protein coupled receptor 33 / Q49SQ1* / G protein-coupled receptor 33 (gene/pseudogene)*ENSMUSG0000003514828
C5ar1 / P30993 / C5a anaphylatoxin chemotactic receptor 1 / P21730* / complement C5a receptor 1*ENSMUSG0000004913028
Gpr152 / Q8BXS7 / G protein-coupled receptor 152 / Q8TDT2*ENSMUSG0000004472423
C5ar2 / complement component 5a receptor 2 / Q9P296*ENSMUSG0000007436123


Protein motifs (from Interpro)
Interpro ID Name
 IPR000276  G protein-coupled receptor, rhodopsin-like
 IPR000826  Formyl peptide receptor-related
 IPR017452  GPCR, rhodopsin-like, 7TM


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001934 positive regulation of protein phosphorylation ISO
 biological_processGO:0002430 complement receptor mediated signaling pathway IBA
 biological_processGO:0006935 chemotaxis IEA
 biological_processGO:0006954 inflammatory response IBA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway ISO
 biological_processGO:0007193 adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway ISO
 biological_processGO:0007200 phospholipase C-activating G-protein coupled receptor signaling pathway IDA
 biological_processGO:0007204 positive regulation of cytosolic calcium ion concentration IBA
 biological_processGO:0019722 calcium-mediated signaling ISO
 biological_processGO:0032930 positive regulation of superoxide anion generation IGI
 biological_processGO:0050900 leukocyte migration IBA
 biological_processGO:0050918 positive chemotaxis IGI
 biological_processGO:0060326 cell chemotaxis IBA
 biological_processGO:0070374 positive regulation of ERK1 and ERK2 cascade ISO
 biological_processGO:0090026 positive regulation of monocyte chemotaxis ISO
 biological_processGO:1904646 cellular response to amyloid-beta ISO
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005737 cytoplasm ISO
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0005887 integral component of plasma membrane IBA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0004875 complement receptor activity IBA
 molecular_functionGO:0004930 G-protein coupled receptor activity IEA
 molecular_functionGO:0004982 N-formyl peptide receptor activity IDA
 molecular_functionGO:0005124 scavenger receptor binding ISO


Pathways (from Reactome)
Pathway description
G alpha (q) signalling events
G alpha (i) signalling events
Formyl peptide receptors bind formyl peptides and many other ligands
Neutrophil degranulation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000495 abnormal colon morphology "malformation of the portion of the large intestine between the cecum and the rectum" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Fbxl21tm1Kei/Fbxl21tm1Kei,Fbxl3tm1Kei/Fbxl3tm1Kei
Genetic Background: B6.Cg-Fbxl21tm1Kei Fbxl3tm1Kei

 MP:0000512 intestinal ulcer "lesions in the mucous lining of the intestine" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Fbxl21tm1Kei/Fbxl21tm1Kei,Fbxl3tm1Kei/Fbxl3tm1Kei
Genetic Background: B6.Cg-Fbxl21tm1Kei Fbxl3tm1Kei

 MP:0001876 decreased inflammatory response "less than expected response to injury, infection, or insult" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Batftm1.1Ejt/Batftm1.1Ejt
Genetic Background: involves: 129S/Sv * C57BL/6 * FVB/N

 MP:0002044 colonic adenoma "benign tumors of the large intestine" [J:38772]
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Allelic Composition: Fbxl21tm1Kei/Fbxl21tm1Kei,Fbxl3tm1Kei/Fbxl3tm1Kei
Genetic Background: B6.Cg-Fbxl21tm1Kei Fbxl3tm1Kei

 MP:0002217 small lymph nodes "lymph nodes of decreased size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Batftm1.1Ejt/Batftm1.1Ejt
Genetic Background: involves: 129S/Sv * C57BL/6 * FVB/N

 MP:0002376 abnormal dendritic cell physiology "failure or atypical function of the immunocompetent cells of the lymphoid and hemopoietic systems and skin, which function to process antigens and present them to T cells, thus stimulating cellular immunity" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, J:85808]
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Allelic Composition: Batftm1.1Ejt/Batftm1.1Ejt
Genetic Background: involves: 129S/Sv * C57BL/6 * FVB/N

Allelic Composition: Fpr2tm1.2Jimw/Fpr2tm1.2Jimw
Genetic Background: involves: 129X1/SvJ

 MP:0002419 abnormal innate immunity "anomaly in the function of the early phase of the response to infection; normally, it is present at all times, does not increase with exposure to specific pathogens, and does not discriminate between pathogens" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Batftm1.1Ejt/Batftm1.1Ejt
Genetic Background: involves: 129S/Sv * C57BL/6 * FVB/N

 MP:0002460 decreased circulating immunoglobulin concentration "less than normal immunoglobulin level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Batftm1.1Ejt/Batftm1.1Ejt
Genetic Background: involves: 129S/Sv * C57BL/6 * FVB/N

 MP:0002463 abnormal neutrophil physiology "abnormal function of these granular leukocytes, which stain with neutral dyes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ghrtm1Arge/Ghrtm1Arge,Igf1tm1Arge/Igf1tm1Arge
Genetic Background: involves: 129S/SvEv * C57BL/6J * DBA * MF1

 MP:0002492 decreased IgE "less than normal immunoglobulin class E level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Batftm1.1Ejt/Batftm1.1Ejt
Genetic Background: involves: 129S/Sv * C57BL/6 * FVB/N

 MP:0002816 colitis "local accumulation of fluid, plasma proteins, and leukocytes in the colon region of the large intestine" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Fpr2tm1.2Jimw/Fpr2tm1.2Jimw
Genetic Background: involves: 129X1/SvJ

 MP:0003009 abnormal cytokine secretion "impairment or increase of the cellular release of any of the non-antibody proteins made by inflammatory leukocytes and some non-leukocytic cells that affect the behavior of other cells " [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, smb:Susan M. Bello , Mouse Genome Informatics Curator]
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Allelic Composition: Batftm1.1Ejt/Batftm1.1Ejt
Genetic Background: involves: 129S/Sv * C57BL/6 * FVB/N

 MP:0003724 susceptibility to induced arthritis "more likely to be striken with changes in the synovial membranes and thickening of articular structures, widespread degeneration of the collagen fibers in connective tissues, and by atrophy and rarefaction of bony structures that are induced by inflammatory responses caused by chemical or mechanical agents" [acv:Alicia Valenzuela, Genetic Resources Curator]
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Allelic Composition: Ghrtm1Arge/Ghrtm1Arge,Igf1tm1Arge/Igf1tm1Arge
Genetic Background: involves: 129S/SvEv * C57BL/6J * DBA * MF1

 MP:0003799 impaired macrophage migration "defect in the ability of macrophages to move up a chemotactic gradient" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Ghrtm1Arge/Ghrtm1Arge,Igf1tm1Arge/Igf1tm1Arge
Genetic Background: involves: 129S/SvEv * C57BL/6J * DBA * MF1

Allelic Composition: Fpr2tm1.2Jimw/Fpr2tm1.2Jimw
Genetic Background: B6.129X1-Fpr2tm1.2Jimw

 MP:0004499 increased incidence of chemically-induced tumors "higher than normal frequency of tumor incidence induced by one or more chemical carcinogens or mutagens" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Fpr2tm1.2Jimw/Fpr2tm1.2Jimw
Genetic Background: involves: 129X1/SvJ

 MP:0004842 abnormal large intestine crypts of Lieberkuhn morphology "any structural anomaly in the tubular intestinal glands found in the mucosal membranes of the large intestine" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Fpr2tm1.2Jimw/Fpr2tm1.2Jimw
Genetic Background: involves: 129X1/SvJ

Allelic Composition: Fpr2tm1.1Jimw/Fpr2tm1.1Jimw,Tg(Vil1-cre)997Gum/0
Genetic Background: involves: 129X1/SvJ * C57BL/6J * SJL

 MP:0005087 reduced acute inflammation "less than the expected early reaction of the microcirculation, characterized by movement of fluid and leukocytes from the blood into extravascular tissues; initiated by injury, infection, or local immune response " [Pathology:ISBN 0-397-51047-0, J:74478]
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Allelic Composition: Fpr2tm1.2Jimw/Fpr2tm1.2Jimw
Genetic Background: involves: 129X1/SvJ

 MP:0005088 increased acute inflammation "greater than the expected early reaction of the microcirculation, characterized by movement of fluid and leukocytes from the blood into extravascular tissues; initiated by injury, infection, or local immune response " [Pathology:ISBN 0-397-51047-0]
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Allelic Composition: Ghrtm1Arge/Ghrtm1Arge,Igf1tm1Arge/Igf1tm1Arge
Genetic Background: involves: 129S/SvEv * C57BL/6J * DBA * MF1

 MP:0005164 abnormal response to injury "anomaly in the body s reaction to trauma, especially that by physical means" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Ghrtm1Arge/Ghrtm1Arge,Igf1tm1Arge/Igf1tm1Arge
Genetic Background: involves: 129S/SvEv * C57BL/6J * DBA * MF1

 MP:0008127 decreased dendritic cell number "reduction in the number of a cells of hematopoietic origin, typically resident in particular tissues, specialized in the uptake, processing, and transport of antigens to lymph nodes for the purpose of stimulating an immune response via T cell activation" [ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Fpr2tm1.2Jimw/Fpr2tm1.2Jimw
Genetic Background: B6.129X1-Fpr2tm1.2Jimw

Allelic Composition: Fpr2tm1.2Jimw/Fpr2tm1.2Jimw
Genetic Background: involves: 129X1/SvJ

 MP:0008495 decreased IgG1 level "less than normal immunoglobulin class G1 level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Fpr2tm1.2Jimw/Fpr2tm1.2Jimw
Genetic Background: B6.129X1-Fpr2tm1.2Jimw

 MP:0008497 decreased IgG2b level "less than normal immunoglobulin class G2b level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Fpr2tm1.2Jimw/Fpr2tm1.2Jimw
Genetic Background: B6.129X1-Fpr2tm1.2Jimw

 MP:0008539 decreased susceptibility to induced colitis "decreased severity or induction threshold of colitis upon treatment of an organism with intestinal inflammation agents such as dextran sodium sulfate (DSS)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Fpr2tm1.2Jimw/Fpr2tm1.2Jimw
Genetic Background: involves: 129X1/SvJ

 MP:0008567 decreased interferon-gamma secretion "reduction in the production or release of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893]
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Allelic Composition: Fpr2tm1.2Jimw/Fpr2tm1.2Jimw
Genetic Background: B6.129X1-Fpr2tm1.2Jimw

 MP:0008673 decreased interleukin-13 secretion "reduction in the production or release of a cytokine synthesized by T-cells that produces proliferation, immunoglobulin isotype switching, and immunoglobulin production by immature B-cells, and appears to play a role in regulating inflammatory and immune responses" [MESH:D12.644.276.374.465.513]
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Allelic Composition: Fpr2tm1.2Jimw/Fpr2tm1.2Jimw
Genetic Background: B6.129X1-Fpr2tm1.2Jimw

 MP:0008688 decreased interleukin-2 secretion "reduction in the production or release of a soluble substance elaborated by antigen- or mitogen-stimulated T-cells which induces DNA synthesis in naive lymphocytes" [MESH:D12.644.276.374.465.502]
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Allelic Composition: Fpr2tm1.2Jimw/Fpr2tm1.2Jimw
Genetic Background: B6.129X1-Fpr2tm1.2Jimw

 MP:0008700 decreased interleukin-4 secretion "reduction in the production or release of a soluble factor produced by activated T-cells that induces the expression of MHC class II genes and FC receptors on B-cells and causes their proliferation and differentiation; it also acts on T-cells, mast cells and several other hematopoietic lineage cells" [MESH:D12.644.276.374.465.504]
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Allelic Composition: Fpr2tm1.2Jimw/Fpr2tm1.2Jimw
Genetic Background: B6.129X1-Fpr2tm1.2Jimw

 MP:0008703 decreased interleukin-5 secretion "reduction in the production or release of a cytokine that promotes differentiation and activation of eosinophils; it also triggers activated B-cells to differentiate into immunoglobulin-secreting cells" [MESH:D12.644.276.374.465.505]
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Allelic Composition: Fpr2tm1.2Jimw/Fpr2tm1.2Jimw
Genetic Background: B6.129X1-Fpr2tm1.2Jimw

 MP:0008720 impaired neutrophil migration "defect in the ability of neutrophils to move along a chemotactic gradient" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Fpr2tm1.2Jimw/Fpr2tm1.2Jimw
Genetic Background: B6.129X1-Fpr2tm1.2Jimw

 MP:0008883 abnormal enterocyte proliferation "anomaly in the ability of the enterocyte cell population to undergo expansion by cell division" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Fpr2tm1.2Jimw/Fpr2tm1.2Jimw
Genetic Background: involves: 129X1/SvJ

 MP:0009278 abnormal bone marrow cell physiology "any functional anomaly of any of the cells found in the blood" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Fpr2tm1.2Jimw/Fpr2tm1.2Jimw
Genetic Background: B6.129X1-Fpr2tm1.2Jimw

 MP:0009766 increased sensitivity to xenobiotic induced morbidity/mortality "decrease in the amount of a foreign compound required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Fpr2tm1.2Jimw/Fpr2tm1.2Jimw
Genetic Background: involves: 129X1/SvJ

 MP:0010740 abnormal dendritic cell chemotaxis "anomaly in the movement of a dendritic cell in response to an external stimulus" [GO:0002407]
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Allelic Composition: Fpr2tm1.2Jimw/Fpr2tm1.2Jimw
Genetic Background: involves: 129X1/SvJ

 MP:0010862 decreased respiratory mucosa goblet cell number "reduced number of the cells of the respiratory epithelial lining that produce and secrete mucins" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Fpr2tm1.2Jimw/Fpr2tm1.2Jimw
Genetic Background: B6.129X1-Fpr2tm1.2Jimw

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000022892 App / P12023 / amyloid beta (A4) precursor protein / P05067* / amyloid beta precursor protein*  / complex / reaction
 ENSMUSG00000018927 Ccl6 / P27784 / C-C motif chemokine 6 CCL6(22-95) CCL6(23-95) / CCL15* / CCL23* / Q16663* / P55773* / CCL15-CCL14* / C-C motif chemokine ligand 15* / C-C motif chemokine ligand 23* / CCL15-...  / reaction / complex
 ENSMUSG00000019122 Ccl9 / P51670 / C-C motif chemokine 9 CCL9(29-101) CCL9(30-101) CCL9(31-101) / CCL15* / CCL23* / Q16663* / P55773* / CCL15-CCL14* / C-C motif chemokine ligand 15* / C-C motif chemokine liga...  / complex / reaction
 ENSMUSG00000024659 Anxa1 / P10107 / Annexin A1 / P04083*  / complex / reaction






 

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