ENSMUSG00000042190


Mus musculus

Features
Gene ID: ENSMUSG00000042190
  
Biological name :Cmklr1
  
Synonyms : Cmklr1 / Mus musculus chemokine-like receptor 1 (Cmklr1), transcript variant 1, mRNA. / P97468
  
Possible biological names infered from orthology : chemerin chemokine-like receptor 1 / Q99788
  
Species: Mus musculus
  
Chr. number: 5
Strand: -1
Band: F
Gene start: 113612354
Gene end: 113650426
  
Corresponding Affymetrix probe sets: 10532711 (MoGene1.0st)   1426072_at (Mouse Genome 430 2.0 Array)   1456887_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000036316
Ensembl peptide - ENSMUSP00000115784
Ensembl peptide - ENSMUSP00000121765
NCBI entrez gene - 14747     See in Manteia.
MGI - MGI:109603
RefSeq - XM_006530166
RefSeq - NM_001359060
RefSeq - NM_008153
RefSeq - XM_006530164
RefSeq - XM_006530165
RefSeq Peptide - NP_001345989
RefSeq Peptide - NP_032179
swissprot - P97468
swissprot - Q497D3
swissprot - E9Q8N2
Ensembl - ENSMUSG00000042190
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cmklr1ENSDARG00000090890Danio rerio
 si:ch211-240b21.4ENSDARG00000110362Danio rerio
 si:ch211-240b21.4ENSDARG00000109654Danio rerio
 CMKLR1ENSGALG00000035182Gallus gallus
 CMKLR1ENSG00000174600Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Gpr1 / Q8K087 / G-protein coupled receptor 1 / P46091*ENSMUSG0000004685634
Fpr1 / P33766 / fMet-Leu-Phe receptor / P21462* / formyl peptide receptor 1*ENSMUSG0000004555133
C3ar1 / O09047 / C3a anaphylatoxin chemotactic receptor / Q16581* / complement C3a receptor 1*ENSMUSG0000004055233
Fpr2 / O88536 / Formyl peptide receptor 2 / P25090*ENSMUSG0000005227032
Q3SXG2 / Fpr-rs6 / Formyl peptide receptor-related sequence 6 / FPR3* / P25089* / formyl peptide receptor 3*ENSMUSG0000007127531
Gpr33 / O88416 / Probable G-protein coupled receptor 33 / Q49SQ1* / G protein-coupled receptor 33 (gene/pseudogene)*ENSMUSG0000003514831
Q71MR7 / Fpr-rs7 / Formyl peptide receptor-related sequence 7 / FPR3* / P25089* / formyl peptide receptor 3*ENSMUSG0000007127631
Fpr3 / O08790 / Formyl peptide receptor-related sequence 1 / FPR2* / P25090* / formyl peptide receptor 2*ENSMUSG0000007970031
O88537 / Fpr-rs3 / Formyl peptide receptor-related sequence 3 / FPR3* / P25089* / formyl peptide receptor 3*ENSMUSG0000006070131
A4FUQ5 / Fpr-rs4 / Formyl peptide receptor-related sequence 4 / FPR3* / P25089* / formyl peptide receptor 3*ENSMUSG0000004806230
Ptgdr2 / Q9Z2J6 / Prostaglandin D2 receptor 2 / Q9Y5Y4*ENSMUSG0000003411728
C5ar1 / P30993 / C5a anaphylatoxin chemotactic receptor 1 / P21730* / complement C5a receptor 1*ENSMUSG0000004913026
C5ar2 / complement component 5a receptor 2 / Q9P296*ENSMUSG0000007436122
Gpr152 / Q8BXS7 / G protein-coupled receptor 152 / Q8TDT2*ENSMUSG0000004472422


Protein motifs (from Interpro)
Interpro ID Name
 IPR000276  G protein-coupled receptor, rhodopsin-like
 IPR002258  DEZ orphan receptor
 IPR017452  GPCR, rhodopsin-like, 7TM


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006935 chemotaxis IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway IEA
 biological_processGO:0010759 positive regulation of macrophage chemotaxis IEA
 biological_processGO:0032088 negative regulation of NF-kappaB transcription factor activity IEA
 biological_processGO:0032695 negative regulation of interleukin-12 production IMP
 biological_processGO:0045600 positive regulation of fat cell differentiation IMP
 biological_processGO:0050848 regulation of calcium-mediated signaling IEA
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0004930 G-protein coupled receptor activity IEA


Pathways (from Reactome)
Pathway description
Class A/1 (Rhodopsin-like receptors)


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000219 increased neutrophil count "greater than normal neutrophil numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Fgf18tm1Sjt/Fgf18tm1Sjt,Glg1Gt(KST005)Byg/Glg1+
Genetic Background: B6.129-Glg1Gt(KST005)Byg Fgf18tm1Sjt

 MP:0000685 abnormal immune system morphology "morphological anomalies in the organs or cells associated with the development and formation of lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Fgf18tm1Sjt/Fgf18tm1Sjt,Glg1Gt(KST005)Byg/Glg1+
Genetic Background: B6.129-Glg1Gt(KST005)Byg Fgf18tm1Sjt

 MP:0001861 lung inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the lung" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Fgf18tm1Sjt/Fgf18tm1Sjt,Glg1Gt(KST005)Byg/Glg1+
Genetic Background: B6.129-Glg1Gt(KST005)Byg Fgf18tm1Sjt

 MP:0002123 abnormal hematopoiesis "abnormal development of the enucleated fetal and adult erythrocytes that develop in the aorta, genital ridge and mesonephros region and later in the fetal and adult liver" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Fgf18tm1Sjt/Fgf18tm1Sjt,Glg1Gt(KST005)Byg/Glg1+
Genetic Background: B6.129-Glg1Gt(KST005)Byg Fgf18tm1Sjt

 MP:0002376 abnormal dendritic cell physiology "failure or atypical function of the immunocompetent cells of the lymphoid and hemopoietic systems and skin, which function to process antigens and present them to T cells, thus stimulating cellular immunity" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, J:85808]
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Allelic Composition: Fgf18tm1Sjt/Fgf18tm1Sjt,Glg1Gt(KST005)Byg/Glg1+
Genetic Background: B6.129-Glg1Gt(KST005)Byg Fgf18tm1Sjt

 MP:0002452 abnormal antigen presenting cell physiology "impairment or abnormality of the function of cells involved in making antigen recognizable by lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Fgf18tm1Sjt/Fgf18tm1Sjt,Glg1Gt(KST005)Byg/Glg1+
Genetic Background: B6.129-Glg1Gt(KST005)Byg Fgf18tm1Sjt

 MP:0003799 impaired macrophage migration "defect in the ability of macrophages to move up a chemotactic gradient" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Rpl38Ts/Rpl38+
Genetic Background: TSJ/Le

 MP:0008245 abnormal alveolar macrophage morphology "any structural anomaly of the round, granular, mononuclear phagocytes found in the alveoli of the lungs which ingest small inhaled particles resulting in degradation and presentation of the antigen to immunocompetent cells" [CL:0000583, MESH:A.11.329.372.600]
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Allelic Composition: Fgf18tm1Sjt/Fgf18tm1Sjt,Glg1Gt(KST005)Byg/Glg1+
Genetic Background: B6.129-Glg1Gt(KST005)Byg Fgf18tm1Sjt

 MP:0008719 impaired neutrophil recruitment "reduced diffusion or accumulation of neutrophils in tissues or cells in response to a wide variety of substances released at the sites of inflammatory reactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Rpl38Ts/Rpl38+
Genetic Background: TSJ/Le

 MP:0008735 increased susceptibility to endotoxin shock "more than the expected early reaction of the microcirculation to endotoxins such as LPS, characterized by movement of fluid and leukocytes from the blood into extravascular tissues and often resulting in death" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Fgf18tm1Sjt/Fgf18tm1Sjt,Glg1Gt(KST005)Byg/Glg1+
Genetic Background: B6.129-Glg1Gt(KST005)Byg Fgf18tm1Sjt

 MP:0010760 abnormal macrophage chemotaxis "anomaly in the movement of a macrophage guided by a specific chemical concentration gradient" [GO:0048246]
Show

Allelic Composition: Fgf18tm1Sjt/Fgf18tm1Sjt,Glg1Gt(KST005)Byg/Glg1+
Genetic Background: B6.129-Glg1Gt(KST005)Byg Fgf18tm1Sjt

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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