ENSMUSG00000034117


Mus musculus

Features
Gene ID: ENSMUSG00000034117
  
Biological name :Ptgdr2
  
Synonyms : Prostaglandin D2 receptor 2 / Ptgdr2 / Q9Z2J6
  
Possible biological names infered from orthology : Q9Y5Y4
  
Species: Mus musculus
  
Chr. number: 19
Strand: 1
Band: A
Gene start: 10937160
Gene end: 10942511
  
Corresponding Affymetrix probe sets: 10461583 (MoGene1.0st)   1422275_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000036159
NCBI entrez gene - 14764     See in Manteia.
MGI - MGI:1330275
RefSeq - XM_011247148
RefSeq - NM_009962
RefSeq - XM_006526695
RefSeq - XM_006526696
RefSeq Peptide - NP_034092
swissprot - Q9Z2J6
Ensembl - ENSMUSG00000034117
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 PTGDR2ENSG00000183134Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Fpr2 / O88536 / Formyl peptide receptor 2 / P25090*ENSMUSG0000005227028
C3ar1 / O09047 / C3a anaphylatoxin chemotactic receptor / Q16581* / complement C3a receptor 1*ENSMUSG0000004055228
Fpr3 / O08790 / Formyl peptide receptor-related sequence 1 / FPR2* / P25090* / formyl peptide receptor 2*ENSMUSG0000007970027
Fpr1 / P33766 / fMet-Leu-Phe receptor / P21462* / formyl peptide receptor 1*ENSMUSG0000004555127
Cmklr1 / P97468 / Mus musculus chemokine-like receptor 1 (Cmklr1), transcript variant 1, mRNA. / Q99788* / chemerin chemokine-like receptor 1*ENSMUSG0000004219027
A4FUQ5 / Fpr-rs4 / Formyl peptide receptor-related sequence 4 / FPR3* / P25089* / formyl peptide receptor 3*ENSMUSG0000004806226
Q3SXG2 / Fpr-rs6 / Formyl peptide receptor-related sequence 6 / FPR3* / P25089* / formyl peptide receptor 3*ENSMUSG0000007127526
Q71MR7 / Fpr-rs7 / Formyl peptide receptor-related sequence 7 / FPR3* / P25089* / formyl peptide receptor 3*ENSMUSG0000007127626
Gpr1 / Q8K087 / G-protein coupled receptor 1 / P46091*ENSMUSG0000004685626
O88537 / Fpr-rs3 / Formyl peptide receptor-related sequence 3 / FPR3* / P25089* / formyl peptide receptor 3*ENSMUSG0000006070126
Gpr33 / O88416 / Probable G-protein coupled receptor 33 / Q49SQ1* / G protein-coupled receptor 33 (gene/pseudogene)*ENSMUSG0000003514824
Gpr152 / Q8BXS7 / G protein-coupled receptor 152 / Q8TDT2*ENSMUSG0000004472423
C5ar1 / P30993 / C5a anaphylatoxin chemotactic receptor 1 / P21730* / complement C5a receptor 1*ENSMUSG0000004913022
C5ar2 / complement component 5a receptor 2 / Q9P296*ENSMUSG0000007436121


Protein motifs (from Interpro)
Interpro ID Name
 IPR000276  G protein-coupled receptor, rhodopsin-like
 IPR017452  GPCR, rhodopsin-like, 7TM


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006935 chemotaxis IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway ISS
 biological_processGO:0007193 adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway IDA
 biological_processGO:0007218 neuropeptide signaling pathway IBA
 biological_processGO:0007268 chemical synaptic transmission IBA
 biological_processGO:0019722 calcium-mediated signaling IEA
 biological_processGO:0045745 positive regulation of G-protein coupled receptor protein signaling pathway IDA
 biological_processGO:2000255 negative regulation of male germ cell proliferation IMP
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005887 integral component of plasma membrane IBA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0043005 neuron projection IBA
 molecular_functionGO:0001785 prostaglandin J receptor activity IDA
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0004930 G-protein coupled receptor activity ISS
 molecular_functionGO:0004956 prostaglandin D receptor activity IEA
 molecular_functionGO:0004958 prostaglandin F receptor activity IDA
 molecular_functionGO:0042923 neuropeptide binding IBA


Pathways (from Reactome)
Pathway description
Prostanoid ligand receptors
G alpha (i) signalling events


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001785 edema "an accumulation of an excessive amount of watery fluid in cells or intercellular tissues" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54065]
Show

Allelic Composition: Pla2g5tm1Jarm/Pla2g5tm1Jarm
Genetic Background: B6.129-Pla2g5tm1Jarm

 MP:0001845 abnormal inflammatory response "aberrant reaction of the microcirculation characterized by movement of fluid and leukocytes from the blood into extravascular tissues" [Pathology:ISBN 0-397-51047-0]
Show

Allelic Composition: Destm1Cap/Destm1Cap
Genetic Background: involves: 129S7/SvEvBrd

 MP:0001876 decreased inflammatory response "less than expected response to injury, infection, or insult" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Destm1Cap/Destm1Cap
Genetic Background: involves: 129S7/SvEvBrd

 MP:0002492 decreased IgE "less than normal immunoglobulin class E level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Destm1Cap/Destm1Cap
Genetic Background: involves: 129S7/SvEvBrd

 MP:0003009 abnormal cytokine secretion "impairment or increase of the cellular release of any of the non-antibody proteins made by inflammatory leukocytes and some non-leukocytic cells that affect the behavior of other cells " [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, smb:Susan M. Bello , Mouse Genome Informatics Curator]
Show

Allelic Composition: Tor1atm1Wtd/Tor1atm2Wtd
Genetic Background: involves: 129S1/Sv

 MP:0005011 increased eosinophil count "greater than normal eosinophil numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Tor1atm1Wtd/Tor1atm2Wtd
Genetic Background: involves: 129S1/Sv

 MP:0005596 increased susceptibility to type I hypersensitvity reaction "greater likelihood of developing a response manifested by localized or generalized reaction that occurs immediately (minutes) after exposure to an antigen to which the person/animal was previously sensitized; it is IgE-mediated, and mast cell activation and degranulation are hallmarks" [Pathology:ISBN 0-397-51047-0, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Pla2g5tm1Jarm/Pla2g5tm1Jarm
Genetic Background: B6.129-Pla2g5tm1Jarm

 MP:0005616 decreased susceptibility to type IV hypersensitivity reaction "less likelihood of or resistance to developing an antigen-elicited cellular immune reaction that results in tissue damage, but does not require Ab participation; the response is seen at the area of contact" [Pathology:ISBN 0-397-51047-0, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Destm1Cap/Destm1Cap
Genetic Background: involves: 129S7/SvEvBrd

 MP:0008721 abnormal chemokine level "deviation from the normal levels of any of the class of pro-inflammatory cytokines that attract and activate leukocytes" [MESH:D12.644.276.374.200]
Show

Allelic Composition: Destm1Cap/Destm1Cap
Genetic Background: involves: 129S7/SvEvBrd

 MP:0008723 impaired eosinophil recruitment "reduced diffusion or accumulation of eosinophils in tissues or cells in response to a wide variety of substances released at the sites of inflammatory reactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Destm1Cap/Destm1Cap
Genetic Background: involves: 129S7/SvEvBrd

 MP:0009815 decreased prostaglandin level "reduction in the amount in the body of any of a class of mediators with effects of vasodilation, vasoconstriction, and smooth muscle stimulation" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Destm1Cap/Destm1Cap
Genetic Background: involves: 129S7/SvEvBrd

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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