ENSG00000171860


Homo sapiens

Features
Gene ID: ENSG00000171860
  
Biological name :C3AR1
  
Synonyms : C3AR1 / complement C3a receptor 1 / Q16581
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 12
Strand: -1
Band: p13.31
Gene start: 8058302
Gene end: 8066471
  
Corresponding Affymetrix probe sets: 209906_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000302079
Ensembl peptide - ENSP00000444500
NCBI entrez gene - 719     See in Manteia.
OMIM - 605246
RefSeq - NM_004054
RefSeq Peptide - NP_001313404
RefSeq Peptide - NP_004045
RefSeq Peptide - NP_001313406
swissprot - Q16581
swissprot - A8K2H7
swissprot - F5GZE6
Ensembl - ENSG00000171860
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CU861476.1ENSDARG00000031749Danio rerio
 C3AR1ENSGALG00000013218Gallus gallus
 C3ar1ENSMUSG00000040552Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
CMKLR1 / Q99788 / chemerin chemokine-like receptor 1ENSG0000017460025
FPR2 / P25090 / formyl peptide receptor 2ENSG0000017104925
C5AR1 / P21730 / complement C5a receptor 1ENSG0000019740525
PTGDR2 / Q9Y5Y4 / prostaglandin D2 receptor 2ENSG0000018313424
FPR1 / P21462 / formyl peptide receptor 1ENSG0000017105123
FPR3 / P25089 / formyl peptide receptor 3ENSG0000018747423
GPR1 / P46091 / G protein-coupled receptor 1ENSG0000018367122
GPR33 / Q49SQ1 / G protein-coupled receptor 33 (gene/pseudogene)ENSG0000021494322
C5AR2 / Q9P296 / complement component 5a receptor 2ENSG0000013483022
GPR32 / O75388 / G protein-coupled receptor 32ENSG0000014251120
GPR152 / Q8TDT2 / G protein-coupled receptor 152ENSG0000017551418


Protein motifs (from Interpro)
Interpro ID Name
 IPR000276  G protein-coupled receptor, rhodopsin-like
 IPR000826  Formyl peptide receptor-related
 IPR001644  C3a anaphylatoxin chemotactic receptor
 IPR002234  Anaphylatoxin chemotactic receptor family
 IPR017452  GPCR, rhodopsin-like, 7TM


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002430 complement receptor mediated signaling pathway IEA
 biological_processGO:0006935 chemotaxis IEA
 biological_processGO:0006954 inflammatory response TAS
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway IEA
 biological_processGO:0007200 phospholipase C-activating G-protein coupled receptor signaling pathway IBA
 biological_processGO:0007204 positive regulation of cytosolic calcium ion concentration TAS
 biological_processGO:0008015 blood circulation TAS
 biological_processGO:0010575 positive regulation of vascular endothelial growth factor production IEA
 biological_processGO:0010759 positive regulation of macrophage chemotaxis IEA
 biological_processGO:0030449 regulation of complement activation TAS
 biological_processGO:0043312 neutrophil degranulation TAS
 biological_processGO:0045766 positive regulation of angiogenesis IEA
 biological_processGO:0050900 leukocyte migration IBA
 biological_processGO:0060326 cell chemotaxis IBA
 biological_processGO:0090023 positive regulation of neutrophil chemotaxis IEA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0005887 integral component of plasma membrane TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0035577 azurophil granule membrane TAS
 cellular_componentGO:0035579 specific granule membrane TAS
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0004875 complement receptor activity IEA
 molecular_functionGO:0004876 complement component C3a receptor activity IEA
 molecular_functionGO:0004930 G-protein coupled receptor activity IEA


Pathways (from Reactome)
Pathway description
Peptide ligand-binding receptors
G alpha (i) signalling events
Neutrophil degranulation
Regulation of Complement cascade


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000125730 C3 / P01024 / complement C3  / reaction / complex






 

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