ENSG00000171051


Homo sapiens

Features
Gene ID: ENSG00000171051
  
Biological name :FPR1
  
Synonyms : formyl peptide receptor 1 / FPR1 / P21462
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 19
Strand: -1
Band: q13.41
Gene start: 51745172
Gene end: 51804110
  
Corresponding Affymetrix probe sets: 205118_at (Human Genome U133 Plus 2.0 Array)   205119_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000302707
Ensembl peptide - ENSP00000470750
Ensembl peptide - ENSP00000471493
Ensembl peptide - ENSP00000472936
NCBI entrez gene - 2357     See in Manteia.
OMIM - 136537
RefSeq - NM_002029
RefSeq - NM_001193306
RefSeq Peptide - NP_001180235
RefSeq Peptide - NP_002020
swissprot - P21462
swissprot - M0QZT0
swissprot - M0R315
Ensembl - ENSG00000171051
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 Fpr1ENSMUSG00000045551Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
FPR2 / P25090 / formyl peptide receptor 2ENSG0000017104969
FPR3 / P25089 / formyl peptide receptor 3ENSG0000018747459
CMKLR1 / Q99788 / chemerin chemokine-like receptor 1ENSG0000017460034
C3AR1 / Q16581 / complement C3a receptor 1ENSG0000017186031
PTGDR2 / Q9Y5Y4 / prostaglandin D2 receptor 2ENSG0000018313430
GPR1 / P46091 / G protein-coupled receptor 1ENSG0000018367130
GPR32 / O75388 / G protein-coupled receptor 32ENSG0000014251130
C5AR1 / P21730 / complement C5a receptor 1ENSG0000019740529
GPR33 / Q49SQ1 / G protein-coupled receptor 33 (gene/pseudogene)ENSG0000021494328
GPR152 / Q8TDT2 / G protein-coupled receptor 152ENSG0000017551425
C5AR2 / Q9P296 / complement component 5a receptor 2ENSG0000013483025


Protein motifs (from Interpro)
Interpro ID Name
 IPR000276  G protein-coupled receptor, rhodopsin-like
 IPR000826  Formyl peptide receptor-related
 IPR017452  GPCR, rhodopsin-like, 7TM
 IPR027345  Formyl peptide receptor 1


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000187 activation of MAPK activity TAS
 biological_processGO:0002430 complement receptor mediated signaling pathway IBA
 biological_processGO:0006935 chemotaxis TAS
 biological_processGO:0006954 inflammatory response IBA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway IEA
 biological_processGO:0007188 adenylate cyclase-modulating G-protein coupled receptor signaling pathway TAS
 biological_processGO:0007200 phospholipase C-activating G-protein coupled receptor signaling pathway IDA
 biological_processGO:0007204 positive regulation of cytosolic calcium ion concentration IBA
 biological_processGO:0007263 nitric oxide mediated signal transduction TAS
 biological_processGO:0019221 cytokine-mediated signaling pathway TAS
 biological_processGO:0043312 neutrophil degranulation TAS
 biological_processGO:0050900 leukocyte migration IBA
 biological_processGO:0060326 cell chemotaxis IBA
 cellular_componentGO:0005622 intracellular ISS
 cellular_componentGO:0005886 plasma membrane ISS
 cellular_componentGO:0005887 integral component of plasma membrane IBA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030667 secretory granule membrane TAS
 cellular_componentGO:0035577 azurophil granule membrane TAS
 cellular_componentGO:0101003 ficolin-1-rich granule membrane TAS
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0004875 complement receptor activity IBA
 molecular_functionGO:0004930 G-protein coupled receptor activity IEA
 molecular_functionGO:0004982 N-formyl peptide receptor activity IEA
 molecular_functionGO:0005124 scavenger receptor binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0050786 RAGE receptor binding IEA


Pathways (from Reactome)
Pathway description
G alpha (i) signalling events
Formyl peptide receptors bind formyl peptides and many other ligands
Interleukin-10 signaling
Neutrophil degranulation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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