ENSMUSG00000041959


Mus musculus

Features
Gene ID: ENSMUSG00000041959
  
Biological name :S100a10
  
Synonyms : P08207 / S100a10 / S100 calcium binding protein A10 (calpactin)
  
Possible biological names infered from orthology : P60903 / S100 calcium binding protein A10
  
Species: Mus musculus
  
Chr. number: 3
Strand: 1
Band: F2.1
Gene start: 93555080
Gene end: 93564643
  
Corresponding Affymetrix probe sets: 10493995 (MoGene1.0st)   1416762_at (Mouse Genome 430 2.0 Array)   1439348_at (Mouse Genome 430 2.0 Array)   1456642_x_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000036949
Ensembl peptide - ENSMUSP00000130712
NCBI entrez gene - 20194     See in Manteia.
MGI - MGI:1339468
RefSeq - XM_017319508
RefSeq - NM_009112
RefSeq Peptide - NP_033138
swissprot - P08207
swissprot - Q3TC45
Ensembl - ENSMUSG00000041959
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 s100a10aENSDARG00000037425Danio rerio
 s100a10bENSDARG00000025254Danio rerio
 P27003ENSGALG00000028774Gallus gallus
 P60903ENSG00000197747Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
S100z / S100 calcium binding protein, zeta / Q8WXG8* / S100 calcium binding protein Z*ENSMUSG0000002167952
S100a1 / S100 calcium binding protein A1 / P23297*ENSMUSG0000004408045
P50543 / S100a11 / Protein S100-A11 / P31949* / S100 calcium binding protein A11*ENSMUSG0000002790737
S100b / P50114 / S100 protein, beta polypeptide, neural / P04271* / S100 calcium binding protein B*ENSMUSG0000003320836
P07091 / S100a4 / S100 calcium binding protein A4 / P26447*ENSMUSG0000000102034
P63084 / S100a5 / S100 calcium binding protein A5 / P33763*ENSMUSG0000000102329
P62818 / S100a3 / S100 calcium binding protein A3ENSMUSG0000000102126
P14069 / S100a6 / S100 calcium binding protein A6 (calcyclin) / P06703* / S100 calcium binding protein A6*ENSMUSG0000000102523
Gm42674 / P33764* / S100A3* / S100 calcium binding protein A3*ENSMUSG0000010551812


Protein motifs (from Interpro)
Interpro ID Name
 IPR001751  S100/Calbindin-D9k, conserved site
 IPR002048  EF-hand domain
 IPR011992  EF-hand domain pair
 IPR013787  S100/CaBP-9k-type, calcium binding, subdomain
 IPR028476  Protein S100-A10


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001765 membrane raft assembly ISO
 biological_processGO:0006900 vesicle budding from membrane ISO
 biological_processGO:0042493 response to drug IEA
 biological_processGO:0043547 positive regulation of GTPase activity ISO
 biological_processGO:0051099 positive regulation of binding IMP
 biological_processGO:0051290 protein heterotetramerization ISO
 biological_processGO:0051496 positive regulation of stress fiber assembly ISO
 biological_processGO:0051894 positive regulation of focal adhesion assembly ISO
 biological_processGO:0072659 protein localization to plasma membrane ISO
 biological_processGO:1900026 positive regulation of substrate adhesion-dependent cell spreading ISO
 cellular_componentGO:0005576 extracellular region ISO
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0019897 extrinsic component of plasma membrane IDA
 cellular_componentGO:0045121 membrane raft ISO
 molecular_functionGO:0005509 calcium ion binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0042803 protein homodimerization activity ISO
 molecular_functionGO:0044325 ion channel binding ISO


Pathways (from Reactome)
Pathway description
Dissolution of Fibrin Clot


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001970 abnormal pain threshold "increased or decreased average level of perception of pain" [J:17792]
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Allelic Composition: S100a10tm1Jnw/S100a10tm1Jnw,Scn10atm2(cre)Jnw/Scn10a+
Genetic Background: involves: 129 * C57BL/6

 MP:0002797 thigmotaxis "preference of a mouse for the side walls of a cage or box; usually an indicator of increased anxiety response" [J:56814]
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Allelic Composition: Col1a1m1Btlr/Col1a1m1Btlr
Genetic Background: C57BL/6J-Col1a1m1Btlr

 MP:0003177 decreased pain threshold "ordinarily painless stimuli, once perceived, are experienced as being painful" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:81734]
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Allelic Composition: S100a10tm1Jnw/S100a10tm1Jnw,Scn10atm2(cre)Jnw/Scn10a+
Genetic Background: involves: 129 * C57BL/6

 MP:0003360 depression-related behavior 
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Allelic Composition: Col1a1m1Btlr/Col1a1m1Btlr
Genetic Background: C57BL/6J-Col1a1m1Btlr

 MP:0003469 decreased single cell response intensity 
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Allelic Composition: S100a10tm1Jnw/S100a10tm1Jnw,Scn10atm2(cre)Jnw/Scn10a+
Genetic Background: involves: 129 * C57BL/6

 MP:0003638 abnormal response/metabolism to endogenous compounds "altered ability or inability to metabolize or respond to substances normally present in the body" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Col1a1m1Btlr/Col1a1m1Btlr
Genetic Background: C57BL/6J-Col1a1m1Btlr

 MP:0005322 abnormal serotonin level "anomalous concentration of biochemical messenger and regulator, found in the CNS, g.i. tract, and produced by platelets; it mediates neurotransmission, g.i. motility, hemostasis, and cardiovascular integrity " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Col1a1m1Btlr/Col1a1m1Btlr
Genetic Background: C57BL/6J-Col1a1m1Btlr

 MP:0009747 impaired behavioral response to xenobiotic "decreased sensitivity to a foreign compound capable of inducing the appearance of behavioral response, such as consumption preference, induced hyperactivity or stereotypic behavior, or increased dosage threshold for the appearance of the behavioral response" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Col1a1m1Btlr/Col1a1m1Btlr
Genetic Background: C57BL/6J-Col1a1m1Btlr

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000041959 P08207 / S100a10 / S100 calcium binding protein A10 (calpactin) / P60903* / S100 calcium binding protein A10*  / complex
 ENSMUSG00000032231 Anxa2 / P07356 / Annexin A2 / P07355*  / complex






 

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