ENSMUSG00000044080


Mus musculus

Features
Gene ID: ENSMUSG00000044080
  
Biological name :S100a1
  
Synonyms : S100a1 / S100 calcium binding protein A1
  
Possible biological names infered from orthology : P23297
  
Species: Mus musculus
  
Chr. number: 3
Strand: -1
Band: F1
Gene start: 90511034
Gene end: 90514392
  
Corresponding Affymetrix probe sets: 10499854 (MoGene1.0st)   1417421_at (Mouse Genome 430 2.0 Array)   1419814_s_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000102963
Ensembl peptide - ENSMUSP00000058237
NCBI entrez gene - 20193     See in Manteia.
MGI - MGI:1338917
RefSeq - NM_011309
RefSeq Peptide - NP_035439
swissprot - D3YUT6
swissprot - Q91V77
Ensembl - ENSMUSG00000044080
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 S100A1ENSGALG00000034458Gallus gallus
 P23297ENSG00000160678Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
S100z / S100 calcium binding protein, zeta / Q8WXG8* / S100 calcium binding protein Z*ENSMUSG0000002167960
S100b / P50114 / S100 protein, beta polypeptide, neural / P04271* / S100 calcium binding protein B*ENSMUSG0000003320856
P07091 / S100a4 / S100 calcium binding protein A4 / P26447*ENSMUSG0000000102048
P08207 / S100a10 / S100 calcium binding protein A10 (calpactin) / P60903* / S100 calcium binding protein A10*ENSMUSG0000004195947
P63084 / S100a5 / S100 calcium binding protein A5 / P33763*ENSMUSG0000000102346
P50543 / S100a11 / Protein S100-A11 / P31949* / S100 calcium binding protein A11*ENSMUSG0000002790741
P14069 / S100a6 / S100 calcium binding protein A6 (calcyclin) / P06703* / S100 calcium binding protein A6*ENSMUSG0000000102540
P62818 / S100a3 / S100 calcium binding protein A3ENSMUSG0000000102139
Gm42674 / P33764* / S100A3* / S100 calcium binding protein A3*ENSMUSG0000010551819


Protein motifs (from Interpro)
Interpro ID Name
 IPR001751  S100/Calbindin-D9k, conserved site
 IPR002048  EF-hand domain
 IPR011992  EF-hand domain pair
 IPR013787  S100/CaBP-9k-type, calcium binding, subdomain
 IPR018247  EF-Hand 1, calcium-binding site
 IPR028486  Protein S100-A1


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IEA
 biological_processGO:0008016 regulation of heart contraction IEA
 biological_processGO:0051000 positive regulation of nitric-oxide synthase activity IEA
 biological_processGO:1901387 positive regulation of voltage-gated calcium channel activity IEA
 biological_processGO:1903672 positive regulation of sprouting angiogenesis IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0016529 sarcoplasmic reticulum IEA
 cellular_componentGO:0030018 Z disc IEA
 cellular_componentGO:0031430 M band IEA
 cellular_componentGO:0031672 A band IEA
 cellular_componentGO:0031674 I band IEA
 cellular_componentGO:0043005 neuron projection IEA
 molecular_functionGO:0005509 calcium ion binding IEA
 molecular_functionGO:0042802 identical protein binding IEA
 molecular_functionGO:0042803 protein homodimerization activity IEA
 molecular_functionGO:0044548 S100 protein binding IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0048306 calcium-dependent protein binding IEA
 molecular_functionGO:0051117 ATPase binding IEA


Pathways (from Reactome)
Pathway description
Regulation of TLR by endogenous ligand


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001364 decreased anxiety-related response "when compared to controls, subjects exhibit fewer responses thought to be indicative of anxiety in behavioral tests" [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator, J:86626, J:85438, J:64043]
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Allelic Composition: Hgftm1Jmw/Hgftm1Jmw,Tg(Mx1-cre)29-4Her/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * SJL

 MP:0001415 increased exploration in new environment "greater amount of time spent investigating new location" [J:28825]
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Allelic Composition: Hgftm1Jmw/Hgftm1Jmw,Tg(Mx1-cre)29-4Her/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * SJL

 MP:0002106 abnormal muscle physiology "anomolous function of the muscle, not due to an anatomical defect" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Vhltm1Mcs/Vhltm1Mcs
Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB/N

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Atp1a1Gt(OST31117)Lex/Atp1a1Gt(OST31117)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0002572 abnormal emotion/affect behavior "altered response in tests for emotional related behaviors" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Hgftm1Jmw/Hgftm1Jmw,Tg(Mx1-cre)29-4Her/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * SJL

 MP:0003034 increased pulmonary vascular resistance "greater than the normal force opposing blood flow in the lung blood vessels" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, RGD:Rat Genome Database submission]
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Allelic Composition: Pkd1tm1Djmp/Pkd1tm1Djmp
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0003461 abnormal response to novel object "altered investigative behavior from controls in reactions associated with exposing an animal to a novel object" [CFG:Center for Functional Genomics, Northwestern University]
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Allelic Composition: Hgftm1Jmw/Hgftm1Jmw,Tg(Mx1-cre)29-4Her/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * SJL

 MP:0003548 pulmonary hypertension "sustained high pulmonary pressure at a level that is likely to result in disease and/or other pathological states" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:54986]
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Allelic Composition: Pkd1tm1Djmp/Pkd1tm1Djmp
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0003820 increased left ventricle systolic pressure "increase in the pressure in the left ventricle as the heart contracts and pumps blood into the arteries" [RGD:Rat Genome Database submission]
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Allelic Composition: Pkd1tm1Djmp/Pkd1tm1Djmp
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0003913 increased right ventricle weight "greater than average weight of the right ventricle compared to the average for a particular strain" [RGD:Rat Genome Database submission]
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Allelic Composition: Pkd1tm1Djmp/Pkd1tm1Djmp
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0003957 abnormal nitric oxide homeostasis "anomaly in the state of equilibrium in the body of nitric oxide, a free radical gas and a potent vasodilator" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Pkd1tm1Djmp/Pkd1tm1Djmp
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0004007 abnormal lung vasculature "malformation or disorganization of the blood vessels of the lung" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Pkd1tm1Djmp/Pkd1tm1Djmp
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005140 decreased cardiac muscle contractility "inability or reduced ability of the heart muscle to shorten or to develop increased tension" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Pkd1tm1Djmp/Pkd1tm1Djmp
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: S100a1tm1Jhh/S100a1+
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0005591 decreased vasodilation "less than the expected or normal widening of the lumen of the blood vessels" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Pkd1tm1Djmp/Pkd1tm1Djmp
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0010758 increased right ventricle systolic pressure "increase in the pressure in the right ventricle as the heart contracts and pumps blood into the arteries" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Pkd1tm1Djmp/Pkd1tm1Djmp
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0011131 abnormal lung endothelial cell physiology "any functional anomaly of the squamous cells forming the lining of the pulmonary vasculature" [MGI:csmith]
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Allelic Composition: Pkd1tm1Djmp/Pkd1tm1Djmp
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0011141 increased lung endothelial cell apoptosis "acceleration in the timing or in the number of endothelial cells in the pulmonary vasculature to undergoing programmed cell death" [MGI:csmith]
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Allelic Composition: Pkd1tm1Djmp/Pkd1tm1Djmp
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000025779 Ly96 / Q9JHF9 / lymphocyte antigen 96 / Q9Y6Y9*  / complex / reaction
 ENSMUSG00000039005 Tlr4 / Q9QUK6 / toll-like receptor 4 / O00206*  / complex / reaction
 ENSMUSG00000044080 S100a1 / S100 calcium binding protein A1 / P23297*  / complex






 

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