ENSMUSG00000019970


Mus musculus

Features
Gene ID: ENSMUSG00000019970
  
Biological name :Sgk1
  
Synonyms : Q9WVC6 / Serine/threonine-protein kinase Sgk1 / Sgk1
  
Possible biological names infered from orthology : O00141 / serum/glucocorticoid regulated kinase 1
  
Species: Mus musculus
  
Chr. number: 10
Strand: 1
Band: A3
Gene start: 21882184
Gene end: 21999903
  
Corresponding Affymetrix probe sets: 10362073 (MoGene1.0st)   1416041_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000114691
Ensembl peptide - ENSMUSP00000114074
Ensembl peptide - ENSMUSP00000115073
Ensembl peptide - ENSMUSP00000020145
Ensembl peptide - ENSMUSP00000128873
Ensembl peptide - ENSMUSP00000120882
Ensembl peptide - ENSMUSP00000116096
Ensembl peptide - ENSMUSP00000090343
Ensembl peptide - ENSMUSP00000097614
NCBI entrez gene - 20393     See in Manteia.
MGI - MGI:1340062
RefSeq - NM_011361
RefSeq - NM_001161845
RefSeq - NM_001161847
RefSeq - NM_001161848
RefSeq - NM_001161849
RefSeq - NM_001161850
RefSeq Peptide - NP_001155317
RefSeq Peptide - NP_035491
RefSeq Peptide - NP_001155322
RefSeq Peptide - NP_001155321
RefSeq Peptide - NP_001155320
RefSeq Peptide - NP_001155319
swissprot - Q9WVC6
swissprot - D3YV51
swissprot - D3YXA3
swissprot - D3Z0E8
swissprot - E9Q1B0
swissprot - E9Q8C1
swissprot - F6RKM6
Ensembl - ENSMUSG00000019970
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 sgk1ENSDARG00000025522Danio rerio
 SGK1ENSGALG00000013971Gallus gallus
 SGK1ENSG00000118515Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Sgk3 / Q9ERE3 / serum/glucocorticoid regulated kinase 3 / Q96BR1* / serum/glucocorticoid regulated kinase family member 3*ENSMUSG0000002591556
Sgk2 / Q9QZS5 / Serine/threonine-protein kinase Sgk2 / Q9HBY8* / SGK2, serine/threonine kinase 2*ENSMUSG0000001786848
Prkcd / P28867 / protein kinase C, delta / Q05655*ENSMUSG0000002194835
Prkch / P23298 / protein kinase C, eta / P24723*ENSMUSG0000002110834
Akt3 / Q9WUA6 / RAC-gamma serine/threonine-protein kinase / Q9Y243* / AKT serine/threonine kinase 3*ENSMUSG0000001969934
Akt1 / P31750 / Mus musculus thymoma viral proto-onco 1 (Akt1), transcript variant 3, mRNA. / P31749* / AKT serine/threonine kinase 1*ENSMUSG0000000172934
Prkce / P16054 / protein kinase C, epsilon / Q02156*ENSMUSG0000004503833
Akt2 / Q60823 / Mus musculus thymoma viral proto-onco 2 (Akt2), transcript variant 4, mRNA. / P31751* / AKT serine/threonine kinase 2*ENSMUSG0000000405633
Prkcq / Q02111 / protein kinase C, theta / Q04759*ENSMUSG0000002677833
Prkca / protein kinase C, alpha / P17252*ENSMUSG0000005096532
Prkcg / P63318 / protein kinase C, gamma / P05129*ENSMUSG0000007881632
Prkcz / Q02956 / protein kinase C, zeta / Q05513*ENSMUSG0000002905331
Prkcb / P68404 / protein kinase C, beta / P05771*ENSMUSG0000005288931
Prkci / Q62074 / protein kinase C, iota / P41743*ENSMUSG0000003764331


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR000961  AGC-kinase, C-terminal
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR017441  Protein kinase, ATP binding site
 IPR017892  Protein kinase, C-terminal
 IPR036871  PX domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0006974 cellular response to DNA damage stimulus IDA
 biological_processGO:0010765 positive regulation of sodium ion transport ISO
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0018105 peptidyl-serine phosphorylation IBA
 biological_processGO:0032869 cellular response to insulin stimulus ISO
 biological_processGO:0032880 regulation of protein localization ISO
 biological_processGO:0035556 intracellular signal transduction IBA
 biological_processGO:0048812 neuron projection morphogenesis IBA
 cellular_componentGO:0005634 nucleus IBA
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0005739 mitochondrion IEA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005789 endoplasmic reticulum membrane IEA
 cellular_componentGO:0005829 cytosol ISO
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016607 nuclear speck ISO
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IEA
 molecular_functionGO:0004712 protein serine/threonine/tyrosine kinase activity ISO
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0035091 phosphatidylinositol binding IEA


Pathways (from Reactome)
Pathway description
Stimuli-sensing channels
Regulation of TP53 Degradation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002666 increased circulating aldosterone level "increased blood concentration of this hormone, secreted by the adrenal cortex, in the bloodstream; regulates sodium conservation and potassium secretion in the distal renal tubule" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Crhr1tm1Wrst/Crhr1+
Genetic Background: either: (involves: 129P2/OlaHsd * 129P/Ola) or (involves: 129P2/OlaHsd * CD-1)

Allelic Composition: Sgk1tm1.2Palm/Sgk1tm1.2Palm
Genetic Background: 129/Sv-Sgk1tm1.2Palm

 MP:0005528 decreased glomerular filtration rate "less than the normal volume of water filtered out of the plasma through glomerular capillary walls into thte Bowman s capsule per unit time" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Crhr1tm1Wrst/Crhr1+
Genetic Background: either: (involves: 129P2/OlaHsd * 129P/Ola) or (involves: 129P2/OlaHsd * CD-1)

 MP:0005619 increased potassium excretion "greater than the normal amount of this alkaline metallic element, the most abundant intracellular ion, voided by the kidneys" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, RGD:Rat Genome Database submission]
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Allelic Composition: Sgk1tm1.2Palm/Sgk1tm1.2Palm
Genetic Background: 129/Sv-Sgk1tm1.2Palm

 MP:0006316 increased urine sodium level "higher than normal concentration of sodium in the urine" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Sgk1tm1.2Palm/Sgk1tm1.2Palm
Genetic Background: 129/Sv-Sgk1tm1.2Palm

 MP:0010180 increased susceptibility to weight loss "greater decrease in body weight over time when compared to the average decrease in weight in response to dietary modification, fasting or caloric restriction" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Crhr1tm1Wrst/Crhr1+
Genetic Background: either: (involves: 129P2/OlaHsd * 129P/Ola) or (involves: 129P2/OlaHsd * CD-1)

 MP:0011442 abnormal renal sodium ion transport "any anomaly in the directed movement of sodium ions (Na+) by the kidney" [GO:0003096]
Show

Allelic Composition: Crhr1tm1Wrst/Crhr1+
Genetic Background: either: (involves: 129P2/OlaHsd * 129P/Ola) or (involves: 129P2/OlaHsd * CD-1)

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000000441 Raf1 / Q99N57 / Mus musculus v-raf-leukemia viral onco 1 (Raf1), transcript variant 3, mRNA. / P04049* / Raf-1 proto-oncogene, serine/threonine kinase*  / complex
 ENSMUSG00000020184 Mdm2 / P23804 / E3 ubiquitin-protein ligase Mdm2 / Q00987* / MDM2 proto-oncogene*  / reaction
 ENSMUSG00000031431 Q9Z2S7 / Tsc22d3 / TSC22 domain family protein 3 / Q99576* / TSC22 domain family member 3*  / complex
 ENSMUSG00000041058 Wwp1 / Q8BZZ3 / WW domain containing E3 ubiquitin protein ligase 1 / Q9H0M0*  / complex
 ENSMUSG00000024122 Pdpk1 / Q9Z2A0 / 3-phosphoinositide-dependent protein kinase 1 / O15530*  / reaction
 ENSMUSG00000028991 Mtor / Q9JLN9 / Serine/threonine-protein kinase mTOR / P42345* / mechanistic target of rapamycin kinase*  / reaction






 

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