ENSMUSG00000022428


Mus musculus

Features
Gene ID: ENSMUSG00000022428
  
Biological name :Cby1
  
Synonyms : 1 / Cby1 / Q9D1C2
  
Possible biological names infered from orthology : chibby family member 1, beta catenin antagonist / Q9Y3M2
  
Species: Mus musculus
  
Chr. number: 15
Strand: 1
Band: E1
Gene start: 79659199
Gene end: 79667660
  
Corresponding Affymetrix probe sets: 10425293 (MoGene1.0st)   1451305_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000023064
NCBI entrez gene - 73739     See in Manteia.
MGI - MGI:1920989
RefSeq - NM_028634
RefSeq - XM_006521484
RefSeq Peptide - NP_082910
swissprot - Q9D1C2
Ensembl - ENSMUSG00000022428
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cby1ENSDARG00000077409Danio rerio
 CBY1ENSGALG00000012218Gallus gallus
 CBY1ENSG00000100211Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
3 / Cby3 / Q9CVN6 / A6NI87* / chibby family member 3*ENSMUSG0000005008735


Protein motifs (from Interpro)
Interpro ID Name
 IPR028118  Chibby family


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0008104 protein localization ISO
 biological_processGO:0030030 cell projection organization IEA
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0030178 negative regulation of Wnt signaling pathway ISO
 biological_processGO:0045444 fat cell differentiation IMP
 biological_processGO:0045892 negative regulation of transcription, DNA-templated ISO
 biological_processGO:0051289 protein homotetramerization ISO
 biological_processGO:0055007 cardiac muscle cell differentiation IMP
 biological_processGO:0060271 cilium assembly IMP
 biological_processGO:0090090 negative regulation of canonical Wnt signaling pathway IMP
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0005802 trans-Golgi network ISO
 cellular_componentGO:0005814 centriole IEA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0016607 nuclear speck IEA
 cellular_componentGO:0036064 ciliary basal body IDA
 cellular_componentGO:0042995 cell projection IEA
 molecular_functionGO:0008013 beta-catenin binding ISO
 molecular_functionGO:0042802 identical protein binding ISO
 molecular_functionGO:0042803 protein homodimerization activity ISO


Pathways (from Reactome)
Pathway description
Deactivation of the beta-catenin transactivating complex


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000208 decreased hematocrit "less than the average percentage of a volume of a blood sample occupied by red blood cells" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: F10tm1Ccmt/F10tm1Ccmt
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001178 pulmonary hypoplasia "reduced size of the respiratory organ due to incomplete development of all or part of the organ " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Pathology , 2nd edition:ISBN 0-397-51047-0]
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Allelic Composition: F10tm1Ccmt/F10tm1Ccmt
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001183 overexpanded alveoli "expanded volume of the saclike terminal dilation of the respiratory bronchioles" [J:66345]
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Allelic Composition: F10tm1Ccmt/F10tm1Ccmt
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
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Allelic Composition: F10tm1Ccmt/F10tm1Ccmt
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001577 anemia "less than normal levels of red blood cells, hemoglobin or volume of packed red blood cells " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]
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Allelic Composition: F10tm1Ccmt/F10tm1Ccmt
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001850 otitis media "middle ear inflammation" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60896]
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Allelic Composition: F10tm1Ccmt/F10tm1Ccmt
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001872 sinus inflammation "increase in susceptibility of the hollow cavities in bone (usually but not exclusively those in the skull) to allergens and/or pathogens" [MGI:tc, J:60896]
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Allelic Composition: F10tm1Ccmt/F10tm1Ccmt
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001925 male infertility "inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
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Allelic Composition: F10tm1Ccmt/F10tm1Ccmt
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002273 abnormal alveolar epithelial cell morphology "any structural anomaly of the cells lining the alveoli " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: F10tm1Ccmt/F10tm1Ccmt
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002274 abnormal type I pneumocyte morphology "any structural anomaly of the epithelial cells lining the alveoli through which gas exchange occurs; these are thin cells with a large surface area" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Pathology , 2nd edition:ISBN 0-397-51047-0]
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Allelic Composition: F10tm1Ccmt/F10tm1Ccmt
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002275 abnormal type II pneumocyte morphology "any structural anomaly of the epithelial cells lining the alveoli that produce surfactant " [Pathology , 2nd edition:ISBN 0-397-51047-0, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: F10tm1Ccmt/F10tm1Ccmt
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002314 abnormal respiratory mechanics "anomaly in the action of the lungs, diaphragm, ribs and chest wall during respiration" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: F10tm1Ccmt/F10tm1Ccmt
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002412 increased susceptibility to bacterial infection "greater likelihood that an organism will develop ill effects from a bacterial infection or from components of or toxins produced by bacteria" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: F10tm1Ccmt/F10tm1Ccmt
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0004391 abnormal respiratory conducting tube "any structural anomaly of the tubes of the respiratory system that allows passage of air from the trachea to the alveoli of the lungs" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: F10tm1Ccmt/F10tm1Ccmt
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0006027 impaired alveologenesis "a block or reduction in the generation of alveoli" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:85546]
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Allelic Composition: F10tm1Ccmt/F10tm1Ccmt
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008489 postnatal slow weight gain "the weight gain over a span of postnatal developmental time is slower than controls, with or without ever attaining a similar weight to controls as adults" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: F10tm1Ccmt/F10tm1Ccmt
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008770 decreased survivor rate "a smaller percentage of organisms than expected survive to adulthood and have a lifespan similar to controls" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: F10tm1Ccmt/F10tm1Ccmt
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008844 decreased subcutaneous adipose tissue amount "reduction in amount of adipose tissue beneath the skin" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: F10tm1Ccmt/F10tm1Ccmt
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0009115 abnormal fat cell morphology "any structural anomaly of a fat-storing cell found mostly in the abdominal cavity and subcutaneous tissue of mammals" [CL:0000449]
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Allelic Composition: Tapbptm1Luc/Tapbptm1Luc
Genetic Background: involves: 129S6/SvEvTac

 MP:0010752 impaired mucociliary clearance "reduced ability to remove mucus and other foreign particles and microorganisms from the lungs by directed ciliary movement and secretory activity of the tracheobronchial submucosal glands" [MESH:E01.370.386.520, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: F10tm1Ccmt/F10tm1Ccmt
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0010809 abnormal Clara cell morphology "any structural anomaly of the rounded, club-shaped, nonciliated cell protruding between ciliated cells in bronchiolar epithelium, believed to be secretory in function" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: F10tm1Ccmt/F10tm1Ccmt
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0010891 increased alveolar lamellar body number "greater number of the specialized secretory organelles found in the cytoplasm of type II pneumocytes and involved in the synthesis, secretion, and reutilization of pulmonary surfactant" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: F10tm1Ccmt/F10tm1Ccmt
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0010896 decreased lung compliance "reduced ability of the lung to distend in response to pressure without disruption, usually expressed as the unit volume of change in the lung per unit of pressure" [ISBN:070202788 "Saunders Comprehensive Veterinary Dictionary, 3rd edition"]
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Allelic Composition: F10tm1Ccmt/F10tm1Ccmt
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0010901 abnormal pulmonary alveolar parenchyma morphology "any structural anomaly of the distinguishing cell types of the lung alveolar tissue, including pulmonary epithelial cells (pneumocytes), alveolar capillary endothelial cells, interstitial cells (fibroblasts) and alveolar macrophages" [ISBN:070202788 "Saunders Comprehensive Veterinary Dictionary, 3rd edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: F10tm1Ccmt/F10tm1Ccmt
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0010902 abnormal pulmonary alveolar sac morphology "any structural anomaly of the small terminal dilation of the alveolar ducts around which the alveoli form pocket-like clusters" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: F10tm1Ccmt/F10tm1Ccmt
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0010936 decreased airway resistance "reduced opposition to flow of air caused by the forces of friction, measured as the ratio of driving pressure to the rate of air flow" [MGI:csmith]
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Allelic Composition: F10tm1Ccmt/F10tm1Ccmt
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0010942 abnormal respiratory epithelium morphology "any structural anomaly of the pseudostratified ciliated epithelium that lines much of the conducting portion of the airway, including part of the nasal cavity and larynx, the trachea, and bronchi" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: F10tm1Ccmt/F10tm1Ccmt
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0010950 abnormal lung hysteresivity "anomaly in the lung tissue property defined as the ratio of dissipated energy to stored energy over a respiratory cycle; it can be measured as the area enclosed by a pressure-volume loop of the lung, and is dependent on composition and microstructure of the tissue components such as the elastic connective tissue" [PMID:2606848]
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Allelic Composition: F10tm1Ccmt/F10tm1Ccmt
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0011044 increased lung elastance "faster ability of the lung to recoil toward its resting dimensions upon removal of pressure without disruption, usually expressed as the unit volume of change in the lung per unit of decreased pressure change; the reciprocal of compliance" [MGI:anna]
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Allelic Composition: F10tm1Ccmt/F10tm1Ccmt
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0011047 increased lung tissue damping "increased value of the respiratory mechanical parameter (G) that is closely related to tissue resistance and reflects the energy dissipation in the lung tissues" [MGI:anna]
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Allelic Composition: F10tm1Ccmt/F10tm1Ccmt
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0011050 abnormal respiratory motile cilium morphology "any structural anomaly of the multiple epithelial tiny, motile hair-like projections, which have a variable arrangement of axonemal microtubules, contains molecular motors, and beat with a characteristic whip-like pattern that promote transport of fluids and other cells across the epithelium of the respiratory tract" [GO:0031514, MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: F10tm1Ccmt/F10tm1Ccmt
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0011053 decreased respiratory motile cilia number "reduced number of the multiple epithelial tiny, motile hair-like projections, which have a variable arrangement of axonemal microtubules, contains molecular motors, and beat with a characteristic whip-like pattern that promote transport of fluids and other cells across the epithelium of the respiratory tract" [GO:0031514, MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: F10tm1Ccmt/F10tm1Ccmt
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: F10tm1Ccmt/F10tm1Ccmt
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000001729 Akt1 / P31750 / Mus musculus thymoma viral proto-onco 1 (Akt1), transcript variant 3, mRNA. / P31749* / AKT serine/threonine kinase 1*  / reaction
 ENSMUSG00000006932 Ctnnb1 / Q02248 / Catenin beta-1 / P35222*  / complex / reaction
 ENSMUSG00000020290 Xpo1 / Q6P5F9 / exportin 1 / O14980*  / complex
 ENSMUSG00000004056 Akt2 / Q60823 / Mus musculus thymoma viral proto-onco 2 (Akt2), transcript variant 4, mRNA. / P31751* / AKT serine/threonine kinase 2*  / reaction






 

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