ENSMUSG00000020290


Mus musculus

Features
Gene ID: ENSMUSG00000020290
  
Biological name :Xpo1
  
Synonyms : exportin 1 / Q6P5F9 / Xpo1
  
Possible biological names infered from orthology : O14980
  
Species: Mus musculus
  
Chr. number: 11
Strand: 1
Band: A3.2
Gene start: 23256041
Gene end: 23298249
  
Corresponding Affymetrix probe sets: 10374590 (MoGene1.0st)   1418442_at (Mouse Genome 430 2.0 Array)   1418443_at (Mouse Genome 430 2.0 Array)   1448070_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000099933
Ensembl peptide - ENSMUSP00000117846
Ensembl peptide - ENSMUSP00000020538
Ensembl peptide - ENSMUSP00000123634
Ensembl peptide - ENSMUSP00000099934
Ensembl peptide - ENSMUSP00000105178
NCBI entrez gene - 103573     See in Manteia.
MGI - MGI:2144013
RefSeq - XM_017314208
RefSeq - XM_006514430
RefSeq - NM_001035226
RefSeq - NM_134014
RefSeq - XM_017314210
RefSeq - XM_017314209
RefSeq Peptide - NP_598775
RefSeq Peptide - NP_001030303
swissprot - Q6P5F9
swissprot - F6YA11
swissprot - A2AKT6
Ensembl - ENSMUSG00000020290
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 xpo1bENSDARG00000063229Danio rerio
 XPO1ENSGALG00000029476Gallus gallus
 XPO1ENSG00000082898Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR001494  Importin-beta, N-terminal domain
 IPR011989  Armadillo-like helical
 IPR013598  Exportin-1/Importin-beta-like
 IPR014877  CRM1 C-terminal domain
 IPR016024  Armadillo-type fold


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000054 ribosomal subunit export from nucleus ISO
 biological_processGO:0000055 ribosomal large subunit export from nucleus IBA
 biological_processGO:0000056 ribosomal small subunit export from nucleus IBA
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IEA
 biological_processGO:0006611 protein export from nucleus ISO
 biological_processGO:0006886 intracellular protein transport IEA
 biological_processGO:0006913 nucleocytoplasmic transport ISO
 biological_processGO:0010824 regulation of centrosome duplication IMP
 biological_processGO:0015031 protein transport IEA
 biological_processGO:0034504 protein localization to nucleus IMP
 biological_processGO:0042176 regulation of protein catabolic process IMP
 biological_processGO:0042254 ribosome biogenesis ISO
 biological_processGO:0042493 response to drug IEA
 biological_processGO:0046825 regulation of protein export from nucleus IMP
 biological_processGO:0051028 mRNA transport IEA
 cellular_componentGO:0000776 kinetochore ISO
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005642 annulate lamellae ISO
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005730 nucleolus IEA
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0005829 cytosol ISO
 cellular_componentGO:0015030 Cajal body IEA
 cellular_componentGO:0031965 nuclear membrane ISO
 cellular_componentGO:0032991 protein-containing complex IEA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle ISO
 molecular_functionGO:0003723 RNA binding IEA
 molecular_functionGO:0005049 nuclear export signal receptor activity ISO
 molecular_functionGO:0005488 binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008536 Ran GTPase binding IEA
 molecular_functionGO:0008565 protein transporter activity IDA
 molecular_functionGO:0019904 protein domain specific binding IEA


Pathways (from Reactome)
Pathway description
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
Separation of Sister Chromatids
Resolution of Sister Chromatid Cohesion
Deactivation of the beta-catenin transactivating complex
HuR (ELAVL1) binds and stabilizes mRNA
RHO GTPases Activate Formins
MAPK6/MAPK4 signaling
Mitotic Prometaphase
Cyclin A/B1/B2 associated events during G2/M transition


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000006932 Ctnnb1 / Q02248 / Catenin beta-1 / P35222*  / complex
 ENSMUSG00000022428 1 / Cby1 / Q9D1C2 / Q9Y3M2* / chibby family member 1, beta catenin antagonist*  / complex






 

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