ENSG00000082898


Homo sapiens

Features
Gene ID: ENSG00000082898
  
Biological name :XPO1
  
Synonyms : exportin 1 / O14980 / XPO1
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 2
Strand: -1
Band: p15
Gene start: 61477849
Gene end: 61538626
  
Corresponding Affymetrix probe sets: 208775_at (Human Genome U133 Plus 2.0 Array)   235927_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000388927
Ensembl peptide - ENSP00000390843
Ensembl peptide - ENSP00000413853
Ensembl peptide - ENSP00000408190
Ensembl peptide - ENSP00000407170
Ensembl peptide - ENSP00000406819
Ensembl peptide - ENSP00000406428
Ensembl peptide - ENSP00000394951
Ensembl peptide - ENSP00000393484
Ensembl peptide - ENSP00000384863
Ensembl peptide - ENSP00000385559
Ensembl peptide - ENSP00000385942
NCBI entrez gene - 7514     See in Manteia.
OMIM - 602559
RefSeq - XM_011533099
RefSeq - NM_003400
RefSeq - XM_005264544
RefSeq - XM_005264546
RefSeq - XM_006712094
RefSeq - XM_011533097
RefSeq - XM_011533098
RefSeq Peptide - NP_003391
swissprot - H7BZC5
swissprot - C9JV99
swissprot - O14980
swissprot - C9JQ02
swissprot - C9JKM9
swissprot - C9JF49
swissprot - C9J673
swissprot - C9IZS4
swissprot - F8WF71
swissprot - C9IYM2
Ensembl - ENSG00000082898
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 xpo1bENSDARG00000063229Danio rerio
 XPO1ENSGALG00000029476Gallus gallus
 Xpo1ENSMUSG00000020290Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR001494  Importin-beta, N-terminal domain
 IPR011989  Armadillo-like helical
 IPR013598  Exportin-1/Importin-beta-like
 IPR014877  CRM1 C-terminal domain
 IPR016024  Armadillo-type fold


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000054 ribosomal subunit export from nucleus IMP
 biological_processGO:0000055 ribosomal large subunit export from nucleus IMP
 biological_processGO:0000056 ribosomal small subunit export from nucleus IMP
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IEA
 biological_processGO:0006611 protein export from nucleus IDA
 biological_processGO:0006886 intracellular protein transport IEA
 biological_processGO:0006913 nucleocytoplasmic transport IMP
 biological_processGO:0007062 sister chromatid cohesion TAS
 biological_processGO:0010824 regulation of centrosome duplication IEA
 biological_processGO:0015031 protein transport IEA
 biological_processGO:0016032 viral process TAS
 biological_processGO:0034504 protein localization to nucleus IEA
 biological_processGO:0042176 regulation of protein catabolic process IEA
 biological_processGO:0042254 ribosome biogenesis IMP
 biological_processGO:0042493 response to drug IEA
 biological_processGO:0043488 regulation of mRNA stability TAS
 biological_processGO:0046825 regulation of protein export from nucleus IBA
 biological_processGO:0051028 mRNA transport IEA
 biological_processGO:0075733 intracellular transport of virus TAS
 cellular_componentGO:0000776 kinetochore IDA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005635 nuclear envelope TAS
 cellular_componentGO:0005642 annulate lamellae IDA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005730 nucleolus IDA
 cellular_componentGO:0005737 cytoplasm TAS
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0015030 Cajal body IEA
 cellular_componentGO:0016020 membrane HDA
 cellular_componentGO:0031965 nuclear membrane IDA
 cellular_componentGO:0032991 protein-containing complex IDA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IDA
 cellular_componentGO:0043657 host cell IEA
 molecular_functionGO:0003723 RNA binding IEA
 molecular_functionGO:0005049 nuclear export signal receptor activity IMP
 molecular_functionGO:0005215 transporter activity TAS
 molecular_functionGO:0005488 binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008536 Ran GTPase binding IEA
 molecular_functionGO:0008565 protein transporter activity IEA
 molecular_functionGO:0019904 protein domain specific binding IEA


Pathways (from Reactome)
Pathway description
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
Rev-mediated nuclear export of HIV RNA
NEP/NS2 Interacts with the Cellular Export Machinery
Downregulation of TGF-beta receptor signaling
Separation of Sister Chromatids
Resolution of Sister Chromatid Cohesion
Deactivation of the beta-catenin transactivating complex
HuR (ELAVL1) binds and stabilizes mRNA
RHO GTPases Activate Formins
MAPK6/MAPK4 signaling
Mitotic Prometaphase
Cyclin A/B1/B2 associated events during G2/M transition


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000100211 CBY1 / Q9Y3M2 / chibby family member 1, beta catenin antagonist  / reaction / complex
 ENSG00000099901 P43487 / RANBP1 / RAN binding protein 1  / complex / reaction
 ENSG00000164924 YWHAZ / P63104 / tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta  / complex / reaction
 ENSG00000168036 CTNNB1 / P35222 / catenin beta 1  / reaction / complex
 ENSG00000198742 Q9HCE7 / SMURF1 / SMAD specific E3 ubiquitin protein ligase 1  / complex / reaction
 ENSG00000132341 RAN / P62826 / RAN, member RAS oncogene family  / complex / reaction
 ENSG00000101665 SMAD7 / O15105 / SMAD family member 7  / reaction / complex






 

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