ENSG00000132341


Homo sapiens

Features
Gene ID: ENSG00000132341
  
Biological name :RAN
  
Synonyms : P62826 / RAN / RAN, member RAS oncogene family
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 12
Strand: 1
Band: q24.33
Gene start: 130871879
Gene end: 130877678
  
Corresponding Affymetrix probe sets: 200749_at (Human Genome U133 Plus 2.0 Array)   200750_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000437950
Ensembl peptide - ENSP00000483687
Ensembl peptide - ENSP00000446215
Ensembl peptide - ENSP00000444042
Ensembl peptide - ENSP00000441210
Ensembl peptide - ENSP00000376174
Ensembl peptide - ENSP00000376176
Ensembl peptide - ENSP00000396127
NCBI entrez gene - 5901     See in Manteia.
OMIM - 601179
RefSeq - XM_017019773
RefSeq - NM_001300796
RefSeq - NM_001300797
RefSeq - NM_006325
RefSeq - XM_017019772
RefSeq Peptide - NP_001287725
RefSeq Peptide - NP_001287726
RefSeq Peptide - NP_006316
swissprot - A0A087X0W0
swissprot - B4DV51
swissprot - F5H018
swissprot - J3KQE5
swissprot - H0YFC6
swissprot - P62826
swissprot - B5MDF5
Ensembl - ENSG00000132341
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ranENSDARG00000057026Danio rerio
 RANENSGALG00000002569Gallus gallus
 1700009N14RikENSMUSG00000028287Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q9UNT1 / RABL2B / RAB, member of RAS oncogene family like 2BENSG0000007997427
Q9UBK7 / RABL2A / RAB, member of RAS oncogene family like 2AENSG0000014413426


Protein motifs (from Interpro)
Interpro ID Name
 IPR001806  Small GTPase superfamily
 IPR002041  Ran GTPase
 IPR005225  Small GTP-binding protein domain
 IPR027417  P-loop containing nucleoside triphosphate hydrolase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000055 ribosomal large subunit export from nucleus IMP
 biological_processGO:0000056 ribosomal small subunit export from nucleus IMP
 biological_processGO:0000060 protein import into nucleus, translocation IMP
 biological_processGO:0000070 mitotic sister chromatid segregation IMP
 biological_processGO:0000278 mitotic cell cycle TAS
 biological_processGO:0006259 DNA metabolic process TAS
 biological_processGO:0006409 tRNA export from nucleus TAS
 biological_processGO:0006606 protein import into nucleus IMP
 biological_processGO:0006611 protein export from nucleus IDA
 biological_processGO:0006913 nucleocytoplasmic transport IEA
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0007052 mitotic spindle organization TAS
 biological_processGO:0010586 miRNA metabolic process TAS
 biological_processGO:0015031 protein transport IEA
 biological_processGO:0016032 viral process TAS
 biological_processGO:0030521 androgen receptor signaling pathway NAS
 biological_processGO:0032092 positive regulation of protein binding IDA
 biological_processGO:0035281 pre-miRNA export from nucleus IC
 biological_processGO:0045540 regulation of cholesterol biosynthetic process TAS
 biological_processGO:0045893 positive regulation of transcription, DNA-templated NAS
 biological_processGO:0046039 GTP metabolic process IDA
 biological_processGO:0051301 cell division IEA
 biological_processGO:0060964 regulation of gene silencing by miRNA TAS
 biological_processGO:0061015 snRNA import into nucleus IMP
 biological_processGO:0075733 intracellular transport of virus TAS
 biological_processGO:1902570 protein localization to nucleolus IMP
 cellular_componentGO:0000785 chromatin IDA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005635 nuclear envelope IEA
 cellular_componentGO:0005643 nuclear pore NAS
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005730 nucleolus IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005814 centriole IDA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0016020 membrane HDA
 cellular_componentGO:0030496 midbody IDA
 cellular_componentGO:0032991 protein-containing complex IDA
 cellular_componentGO:0042470 melanosome IEA
 cellular_componentGO:0042565 RNA nuclear export complex IDA
 cellular_componentGO:0043657 host cell IEA
 cellular_componentGO:0055037 recycling endosome IDA
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0000287 magnesium ion binding IDA
 molecular_functionGO:0003682 chromatin binding TAS
 molecular_functionGO:0003713 transcription coactivator activity NAS
 molecular_functionGO:0003723 RNA binding HDA
 molecular_functionGO:0003924 GTPase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005525 GTP binding IEA
 molecular_functionGO:0019003 GDP binding IMP
 molecular_functionGO:0045296 cadherin binding IDA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0046982 protein heterodimerization activity IPI
 molecular_functionGO:0050681 androgen receptor binding NAS
 molecular_functionGO:0070883 pre-miRNA binding IDA
 molecular_functionGO:0140142 nucleocytoplasmic carrier activity IC


Pathways (from Reactome)
Pathway description
Rev-mediated nuclear export of HIV RNA
Regulation of cholesterol biosynthesis by SREBP (SREBF)
NEP/NS2 Interacts with the Cellular Export Machinery
Nuclear import of Rev protein
MicroRNA (miRNA) biogenesis
Transcriptional regulation by small RNAs
tRNA processing in the nucleus


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000133704 IPO8 / O15397 / importin 8  / complex / reaction
 ENSG00000124571 XPO5 / Q9HAV4 / exportin 5  / complex
 ENSG00000072310 P36956 / SREBF1 / sterol regulatory element binding transcription factor 1  / reaction
 ENSG00000108424 KPNB1 / Q14974 / karyopherin subunit beta 1  / complex / reaction
 ENSG00000181163 NPM1 / P06748 / nucleophosmin 1  / reaction / complex
 ENSG00000099901 P43487 / RANBP1 / RAN binding protein 1  / complex / reaction
 ENSG00000198911 Q12772 / SREBF2 / sterol regulatory element binding transcription factor 2  / reaction
 ENSG00000180198 RCC1 / P18754 / regulator of chromosome condensation 1  / reaction
 ENSG00000132341 RAN / P62826 / RAN, member RAS oncogene family  / reaction
 ENSG00000184575 XPOT / O43592 / exportin for tRNA  / complex / reaction
 ENSG00000082898 XPO1 / O14980 / exportin 1  / reaction / complex
 ENSG00000123908 AGO2 / Q9UKV8 / argonaute 2, RISC catalytic component  / reaction






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr