ENSG00000198911


Homo sapiens

Features
Gene ID: ENSG00000198911
  
Biological name :SREBF2
  
Synonyms : Q12772 / SREBF2 / sterol regulatory element binding transcription factor 2
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 22
Strand: 1
Band: q13.2
Gene start: 41833079
Gene end: 41907308
  
Corresponding Affymetrix probe sets: 201247_at (Human Genome U133 Plus 2.0 Array)   201248_s_at (Human Genome U133 Plus 2.0 Array)   242748_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000412287
Ensembl peptide - ENSP00000484441
Ensembl peptide - ENSP00000354476
Ensembl peptide - ENSP00000395728
NCBI entrez gene - 6721     See in Manteia.
OMIM - 600481
RefSeq - XM_017028922
RefSeq - NM_004599
RefSeq - XM_006724310
RefSeq - XM_011530347
RefSeq - XM_017028921
RefSeq Peptide - NP_004590
swissprot - Q12772
swissprot - A0A087X1T2
swissprot - G3V0I8
swissprot - H0Y7E5
swissprot - A0A024R1Q0
Ensembl - ENSG00000198911
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 srebf2ENSDARG00000063438Danio rerio
 SREBF2ENSGALG00000041687Gallus gallus
 Q3U1N2ENSMUSG00000022463Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
P36956 / SREBF1 / sterol regulatory element binding transcription factor 1ENSG0000007231043


Protein motifs (from Interpro)
Interpro ID Name
 IPR011598  Myc-type, basic helix-loop-helix (bHLH) domain
 IPR036638  Helix-loop-helix DNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IDA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006629 lipid metabolic process TAS
 biological_processGO:0008202 steroid metabolic process IEA
 biological_processGO:0008203 cholesterol metabolic process IEA
 biological_processGO:0009267 cellular response to starvation IMP
 biological_processGO:0010886 positive regulation of cholesterol storage IDA
 biological_processGO:0045540 regulation of cholesterol biosynthetic process TAS
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IDA
 biological_processGO:0071404 cellular response to low-density lipoprotein particle stimulus IEP
 biological_processGO:0071499 cellular response to laminar fluid shear stress NAS
 biological_processGO:0072368 regulation of lipid transport by negative regulation of transcription from RNA polymerase II promoter IDA
 biological_processGO:0090370 negative regulation of cholesterol efflux IDA
 biological_processGO:1903146 regulation of autophagy of mitochondrion IMP
 biological_processGO:1903955 positive regulation of protein targeting to mitochondrion IMP
 cellular_componentGO:0000139 Golgi membrane TAS
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005739 mitochondrion IDA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005789 endoplasmic reticulum membrane TAS
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0012507 ER to Golgi transport vesicle membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0031410 cytoplasmic vesicle IEA
 cellular_componentGO:0032937 SREBP-SCAP-Insig complex IDA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IDA
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IDA
 molecular_functionGO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding NAS
 molecular_functionGO:0001078 transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding IDA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008022 protein C-terminus binding IPI
 molecular_functionGO:0044212 transcription regulatory region DNA binding IEA
 molecular_functionGO:0046983 protein dimerization activity IEA
 molecular_functionGO:0070888 E-box binding IDA


Pathways (from Reactome)
Pathway description
Regulation of cholesterol biosynthesis by SREBP (SREBF)
PPARA activates gene expression
Activation of gene expression by SREBF (SREBP)
Transcriptional regulation of white adipocyte differentiation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000125629 INSIG2 / Q9Y5U4 / insulin induced gene 2  / complex
 ENSG00000120837 NFYB / P25208 / nuclear transcription factor Y subunit beta  / complex / reaction
 ENSG00000138802 O95487 / SEC24B / SEC24 homolog B, COPII coat complex component  / complex
 ENSG00000114650 SCAP / Q12770 / SREBF chaperone  / complex
 ENSG00000072310 P36956 / SREBF1 / sterol regulatory element binding transcription factor 1  / reaction / complex
 ENSG00000066136 NFYC / Q13952 / nuclear transcription factor Y subunit gamma  / reaction / complex
 ENSG00000100934 Q15436 / SEC23A / Sec23 homolog A, coat complex II component  / complex
 ENSG00000150961 O94855 / SEC24D / SEC24 homolog D, COPII coat complex component  / complex
 ENSG00000186480 INSIG1 / O15503 / insulin induced gene 1  / complex
 ENSG00000140943 MBTPS1 / Q14703 / membrane bound transcription factor peptidase, site 1  / reaction
 ENSG00000001167 NFYA / P23511 / nuclear transcription factor Y subunit alpha  / reaction / complex
 ENSG00000176986 P53992 / SEC24C / SEC24 homolog C, COPII coat complex component  / complex
 ENSG00000113615 O95486 / SEC24A / SEC24 homolog A, COPII coat complex component  / complex
 ENSG00000198911 Q12772 / SREBF2 / sterol regulatory element binding transcription factor 2  / reaction / complex
 ENSG00000185591 SP1 / P08047 / Sp1 transcription factor  / complex / reaction
 ENSG00000132341 RAN / P62826 / RAN, member RAS oncogene family  / reaction
 ENSG00000108424 KPNB1 / Q14974 / karyopherin subunit beta 1  / complex / reaction
 ENSG00000012174 MBTPS2 / O43462 / membrane bound transcription factor peptidase, site 2  / reaction
 ENSG00000152700 SAR1B / Q9Y6B6 / secretion associated Ras related GTPase 1B  / complex






 

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