ENSMUSG00000022463


Mus musculus

Features
Gene ID: ENSMUSG00000022463
  
Biological name :Srebf2
  
Synonyms : Q3U1N2 / Srebf2 / sterol regulatory element binding factor 2
  
Possible biological names infered from orthology : Q12772 / sterol regulatory element binding transcription factor 2
  
Species: Mus musculus
  
Chr. number: 15
Strand: 1
Band: E1
Gene start: 82147181
Gene end: 82205379
  
Corresponding Affymetrix probe sets: 10425695 (MoGene1.0st)   1426744_at (Mouse Genome 430 2.0 Array)   1452174_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000023100
Ensembl peptide - ENSMUSP00000154839
Ensembl peptide - ENSMUSP00000155022
Ensembl peptide - ENSMUSP00000155331
NCBI entrez gene - 20788     See in Manteia.
MGI - MGI:107585
RefSeq - NM_033218
RefSeq - XM_006520685
RefSeq Peptide - NP_150087
swissprot - Q3U1N2
Ensembl - ENSMUSG00000022463
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 srebf2ENSDARG00000063438Danio rerio
 SREBF2ENSGALG00000041687Gallus gallus
 Q12772ENSG00000198911Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q9WTN3 / Srebf1 / Mus musculus sterol regulatory element binding transcription factor 1 (Srebf1), transcript variant 4, mRNA. / P36956* / sterol regulatory element binding transcription factor 1*ENSMUSG0000002053842


Protein motifs (from Interpro)
Interpro ID Name
 IPR003006  Immunoglobulin/major histocompatibility complex, conserved site
 IPR011598  Myc-type, basic helix-loop-helix (bHLH) domain
 IPR036638  Helix-loop-helix DNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IDA
 biological_processGO:0006629 lipid metabolic process IEA
 biological_processGO:0008202 steroid metabolic process IEA
 biological_processGO:0008203 cholesterol metabolic process IEA
 biological_processGO:0009267 cellular response to starvation IEA
 biological_processGO:0010886 positive regulation of cholesterol storage IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0071404 cellular response to low-density lipoprotein particle stimulus IEA
 biological_processGO:0072368 regulation of lipid transport by negative regulation of transcription from RNA polymerase II promoter IEA
 biological_processGO:0090370 negative regulation of cholesterol efflux IEA
 biological_processGO:1903146 regulation of autophagy of mitochondrion IEA
 biological_processGO:1903955 positive regulation of protein targeting to mitochondrion IEA
 cellular_componentGO:0000139 Golgi membrane IEA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005739 mitochondrion IEA
 cellular_componentGO:0005783 endoplasmic reticulum ISO
 cellular_componentGO:0005789 endoplasmic reticulum membrane IEA
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0012507 ER to Golgi transport vesicle membrane IEA
 cellular_componentGO:0016020 membrane IDA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0031410 cytoplasmic vesicle IEA
 cellular_componentGO:0032937 SREBP-SCAP-Insig complex IEA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IEA
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IEA
 molecular_functionGO:0001078 transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding IEA
 molecular_functionGO:0003677 DNA binding IDA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008022 protein C-terminus binding IEA
 molecular_functionGO:0043565 sequence-specific DNA binding ISO
 molecular_functionGO:0044212 transcription regulatory region DNA binding IDA
 molecular_functionGO:0046983 protein dimerization activity IEA
 molecular_functionGO:0070888 E-box binding IEA


Pathways (from Reactome)
Pathway description
Regulation of cholesterol biosynthesis by SREBP (SREBF)


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001191 abnormal skin condition "anomalous state of the skin" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Grid2Lc/Grid2+
Genetic Background: B6CBACa Aw-J/A-Grid2Lc/J

Allelic Composition: Srebf2Gt(YTA054)Byg/Srebf2lop13
Genetic Background: involves: 129P2/OlaHsd * 129T1/Sv * C57BL/6J

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Srebf2tm1Jdh/Srebf2tm1Jdh,Speer6-ps1Tg(Alb-cre)21Mgn/?
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * DBA

 MP:0001304 cataracts "complete or partial opacity of the lens" [J:65031]
Show

Allelic Composition: Grid2Lc/Grid2+
Genetic Background: B6CBACa Aw-J/A-Grid2Lc/J

Allelic Composition: Srebf2Gt(YTA054)Byg/Srebf2lop13
Genetic Background: involves: 129P2/OlaHsd * 129T1/Sv * C57BL/6J

 MP:0002118 abnormal lipid homeostasis "anomaly in the state of equilibrium in the body with respect to lipids in the fluids and tissues" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Gabrb3tm2.1Uru/Gabrb3tm2.1Uru
Genetic Background: B6J.129S6(Cg)-Gabrb3tm2.1Uru

 MP:0002644 decreased circulating triglyceride level "lower than normal concentration of triacylglycerols in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Srebf2tm1Jdh/Srebf2tm1Jdh,Speer6-ps1Tg(Alb-cre)21Mgn/?
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * DBA

 MP:0002840 abnormal lens fibers morphology "structural anomaly of the elongated cells of the crystalline lens of the eye" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Grid2Lc/Grid2+
Genetic Background: B6CBACa Aw-J/A-Grid2Lc/J

Allelic Composition: Srebf2Gt(YTA054)Byg/Srebf2lop13
Genetic Background: involves: 129P2/OlaHsd * 129T1/Sv * C57BL/6J

 MP:0003983 decreased cholesterol level "less than normal concentration in the body of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Grid2Lc/Grid2+
Genetic Background: B6CBACa Aw-J/A-Grid2Lc/J

 MP:0005179 decreased total circulating cholesterol level "less than the normal concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Srebf2tm1Jdh/Srebf2tm1Jdh,Speer6-ps1Tg(Alb-cre)21Mgn/?
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * DBA

 MP:0009356 decreased liver triglyceride level "lower than normal concentration of triacylglycerols in the liver" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Srebf2tm1Jdh/Srebf2tm1Jdh,Speer6-ps1Tg(Alb-cre)21Mgn/?
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * DBA

 MP:0010026 decreased liver cholesterol level "less than normal amount in the liver of the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones; it is a component of the plasma membrane lipid bilayer and of plasma lipoproteins and can be found in all animal tissues" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Grid2Lc/Grid2+
Genetic Background: B6CBACa Aw-J/A-Grid2Lc/J

Allelic Composition: Srebf2tm1Jdh/Srebf2tm1Jdh,Speer6-ps1Tg(Alb-cre)21Mgn/?
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * DBA

 MP:0010161 decreased brain cholesterol level "less than normal amount in the brain of the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones; it is a component of the plasma membrane lipid bilayer and of plasma lipoproteins and can be found in all animal tissues" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Grid2Lc/Grid2+
Genetic Background: B6CBACa Aw-J/A-Grid2Lc/J

 MP:0010254 nuclear cataracts "a lens opacity located in the dense, central part of the lens" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", ISBN:978-0-8493-0864-2 "Smith R.S. et al (ed.) Systematic Evaluation of the Mouse Eye: Anatomy, Pathology, and Biomethods"]
Show

Allelic Composition: Grid2Lc/Grid2+
Genetic Background: B6CBACa Aw-J/A-Grid2Lc/J

 MP:0011091 complete prenatal lethality "death of all organisms of a given genotype in a population between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Glra1tm2.1Geh/Glra1tm2.1Geh
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * C57BL/6J * SJL

 MP:0011101 partial prenatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Srebf2Gt(YTA054)Byg/Srebf2lop13
Genetic Background: involves: 129P2/OlaHsd * 129T1/Sv * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000001440 Kpnb1 / P70168 / Importin subunit beta-1 / Q14974* / karyopherin subunit beta 1*  / complex / reaction
 ENSMUSG00000020538 Q9WTN3 / Srebf1 / Mus musculus sterol regulatory element binding transcription factor 1 (Srebf1), transcript variant 4, mRNA. / P36956* / sterol regulatory element binding transcription factor 1*  / reaction / complex
 ENSMUSG00000022463 Q3U1N2 / Srebf2 / sterol regulatory element binding factor 2 / Q12772* / sterol regulatory element binding transcription factor 2*  / complex / reaction
 ENSMUSG00000028287 1700009N14Rik / RIKEN cDNA 1700009N14 gene / RAN* / P62826* / RAN, member RAS oncogene family*  / reaction
 ENSMUSG00000091736 Yy2 / Q3TTC2 / Yy2 transcription factor / O15391*  / reaction
 ENSMUSG00000046873 Q3TTC2 / Mbtps2 / Q8CHX6 / Membrane-bound transcription factor site-2 protease / O43462* / membrane bound transcription factor peptidase, site 2*  / reaction
 ENSMUSG00000031835 Mbtps1 / Q9WTZ2 / Membrane-bound transcription factor site-1 protease / Q14703* / membrane bound transcription factor peptidase, site 1*  / reaction
 ENSMUSG00000032485 Scap / Q6GQT6 / SREBF chaperone / Q12770*  / complex






 

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