ENSMUSG00000001440


Mus musculus

Features
Gene ID: ENSMUSG00000001440
  
Biological name :Kpnb1
  
Synonyms : Importin subunit beta-1 / Kpnb1 / P70168
  
Possible biological names infered from orthology : karyopherin subunit beta 1 / Q14974
  
Species: Mus musculus
  
Chr. number: 11
Strand: -1
Band: D
Gene start: 97159714
Gene end: 97187881
  
Corresponding Affymetrix probe sets: 10390352 (MoGene1.0st)   1416925_at (Mouse Genome 430 2.0 Array)   1434357_a_at (Mouse Genome 430 2.0 Array)   1448526_at (Mouse Genome 430 2.0 Array)   1451967_x_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000001479
NCBI entrez gene - 16211     See in Manteia.
MGI - MGI:107532
RefSeq - NM_008379
RefSeq Peptide - NP_032405
swissprot - P70168
Ensembl - ENSMUSG00000001440
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 kpnb1ENSDARG00000104889Danio rerio
 KPNB1ENSGALG00000036962Gallus gallus
 KPNB1ENSG00000108424Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR000225  Armadillo
 IPR001494  Importin-beta, N-terminal domain
 IPR011989  Armadillo-like helical
 IPR016024  Armadillo-type fold
 IPR021133  HEAT, type 2


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000060 protein import into nucleus, translocation IBA
 biological_processGO:0006606 protein import into nucleus IEA
 biological_processGO:0006607 NLS-bearing protein import into nucleus IBA
 biological_processGO:0006610 ribosomal protein import into nucleus IEA
 biological_processGO:0006886 intracellular protein transport IEA
 biological_processGO:0007079 mitotic chromosome movement towards spindle pole IEA
 biological_processGO:0007080 mitotic metaphase plate congression IEA
 biological_processGO:0015031 protein transport IEA
 biological_processGO:0030953 astral microtubule organization IEA
 biological_processGO:0031291 Ran protein signal transduction IEA
 biological_processGO:0040001 establishment of mitotic spindle localization IEA
 biological_processGO:0045184 establishment of protein localization IEA
 biological_processGO:0090307 mitotic spindle assembly IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005635 nuclear envelope IEA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0031965 nuclear membrane IEA
 cellular_componentGO:0034399 nuclear periphery IBA
 cellular_componentGO:0071782 endoplasmic reticulum tubular network IEA
 molecular_functionGO:0005488 binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008139 nuclear localization sequence binding IBA
 molecular_functionGO:0008536 Ran GTPase binding IEA
 molecular_functionGO:0008565 protein transporter activity IDA
 molecular_functionGO:0019899 enzyme binding IEA
 molecular_functionGO:0019904 protein domain specific binding IEA
 molecular_functionGO:0051879 Hsp90 protein binding IDA


Pathways (from Reactome)
Pathway description
Regulation of cholesterol biosynthesis by SREBP (SREBF)
Activation of DNA fragmentation factor
Neutrophil degranulation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Cdkn1atm1Led/Cdkn1atm1Led,Gadd45atm1Ajf/Gadd45atm1Ajf
Genetic Background: either: (involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6) or (involves: 129S6/SvEvTac * 129X1/SvJ * C57BL/6)

 MP:0005164 abnormal response to injury "anomaly in the body s reaction to trauma, especially that by physical means" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: EnamAbte2/Enam+
Genetic Background: C3HeB/FeJ-EnamAbte2

 MP:0011096 complete embryonic lethality before somite formation "death of all organisms of a given genotype in a population between the point of implantation and somite formation (Mus: E4.5 to less than E8)" [MGI:csmith]
Show

Allelic Composition: Cdkn1atm1Led/Cdkn1atm1Led,Gadd45atm1Ajf/Gadd45atm1Ajf
Genetic Background: either: (involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6) or (involves: 129S6/SvEvTac * 129X1/SvJ * C57BL/6)

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000022463 Q3U1N2 / Srebf2 / sterol regulatory element binding factor 2 / Q12772* / sterol regulatory element binding transcription factor 2*  / complex / reaction
 ENSMUSG00000022905 Kpna1 / Q60960 / Importin subunit alpha-5 / P52294* / karyopherin subunit alpha 1*  / complex
 ENSMUSG00000020538 Q9WTN3 / Srebf1 / Mus musculus sterol regulatory element binding transcription factor 1 (Srebf1), transcript variant 4, mRNA. / P36956* / sterol regulatory element binding transcription factor 1*  / complex / reaction
 ENSMUSG00000029027 Dffb / O54788 / DNA fragmentation factor subunit beta / O76075*  / reaction / complex
 ENSMUSG00000028287 1700009N14Rik / RIKEN cDNA 1700009N14 gene / RAN* / P62826* / RAN, member RAS oncogene family*  / reaction / complex
 ENSMUSG00000028974 Dffa / O54786 / DNA fragmentation factor subunit alpha / O00273*  / reaction / complex






 

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