ENSMUSG00000022905


Mus musculus

Features
Gene ID: ENSMUSG00000022905
  
Biological name :Kpna1
  
Synonyms : Importin subunit alpha-5 / Kpna1 / Q60960
  
Possible biological names infered from orthology : karyopherin subunit alpha 1 / P52294
  
Species: Mus musculus
  
Chr. number: 16
Strand: 1
Band: B3
Gene start: 35978750
Gene end: 36037131
  
Corresponding Affymetrix probe sets: 10435470 (MoGene1.0st)   1419548_at (Mouse Genome 430 2.0 Array)   1449503_at (Mouse Genome 430 2.0 Array)   1449504_at (Mouse Genome 430 2.0 Array)   1449505_at (Mouse Genome 430 2.0 Array)   1460260_s_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000134534
Ensembl peptide - ENSMUSP00000004054
Ensembl peptide - ENSMUSP00000133318
Ensembl peptide - ENSMUSP00000133664
Ensembl peptide - ENSMUSP00000133819
Ensembl peptide - ENSMUSP00000133852
Ensembl peptide - ENSMUSP00000134037
NCBI entrez gene - 16646     See in Manteia.
MGI - MGI:103560
RefSeq - XM_011245834
RefSeq - NM_008465
RefSeq - XM_006521814
RefSeq Peptide - NP_032491
swissprot - G3UZK5
swissprot - G3UXF0
swissprot - G3UWJ8
swissprot - Q60960
swissprot - G3UXT6
swissprot - G3UYD2
swissprot - G3UXW7
Ensembl - ENSMUSG00000022905
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 kpna1ENSDARG00000016360Danio rerio
 KPNA1ENSGALG00000014426Gallus gallus
 KPNA1ENSG00000114030Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Kpna6 / O35345 / Importin subunit alpha-7 / O60684* / karyopherin subunit alpha 6*ENSMUSG0000000373181
Kpna4 / O35343 / karyopherin (importin) alpha 4 / O00629* / karyopherin subunit alpha 4*ENSMUSG0000002778247
Kpna3 / O35344 / Importin subunit alpha-4 / O00505* / karyopherin subunit alpha 3*ENSMUSG0000002192947
Kpna2 / P52293 / Importin subunit alpha-1 / P52292* / karyopherin subunit alpha 2*ENSMUSG0000001836246
P52293 / Gm10184 / predicted pseudogene 10184 / KPNA2* / P52292* / karyopherin subunit alpha 2*ENSMUSG0000006687846
Kpna7 / C0LLJ0 / Importin subunit alpha-8 / A9QM74* / karyopherin subunit alpha 7*ENSMUSG0000003877035


Protein motifs (from Interpro)
Interpro ID Name
 IPR000225  Armadillo
 IPR002652  Importin-alpha, importin-beta-binding domain
 IPR011989  Armadillo-like helical
 IPR016024  Armadillo-type fold
 IPR024931  Importin subunit alpha
 IPR032413  Atypical Arm repeat


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006606 protein import into nucleus IEA
 biological_processGO:0006607 NLS-bearing protein import into nucleus IBA
 biological_processGO:0015031 protein transport IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005643 nuclear pore IBA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0030425 dendrite ISS
 molecular_functionGO:0005488 binding IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0008139 nuclear localization sequence binding IBA
 molecular_functionGO:0008565 protein transporter activity IEA
 molecular_functionGO:0061608 nuclear import signal receptor activity IEA


Pathways (from Reactome)
Pathway description
Activation of DNA fragmentation factor


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001120 abnormal uterus morphology "malformation or absence of the female muscular organ of gestation" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ccm2ltm1Mlkn/Ccm2ltm1Mlkn,Ccm2tm1Mlkn/Ccm2+,Heg1tm1Mlkn/Heg1tm2.1Mlkn,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129 * C57BL/6 * SJL

 MP:0001935 reduced litter size "fewer live born pups in a litter compared to average" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ccm2ltm1Mlkn/Ccm2ltm1Mlkn,Ccm2tm1Mlkn/Ccm2+,Heg1tm1Mlkn/Heg1tm2.1Mlkn,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129 * C57BL/6 * SJL

 MP:0002682 reduced number of mature ovarian follicles "fewer than normal numbers of spehroidal cell aggregations in the ovary containing the ovum" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Ccm2ltm1Mlkn/Ccm2ltm1Mlkn,Ccm2tm1Mlkn/Ccm2+,Heg1tm1Mlkn/Heg1tm2.1Mlkn,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129 * C57BL/6 * SJL

 MP:0002907 abnormal parturition "defect in the process of labor and delivery in female animals " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Ccm2ltm1Mlkn/Ccm2ltm1Mlkn,Ccm2tm1Mlkn/Ccm2+,Heg1tm1Mlkn/Heg1tm2.1Mlkn,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129 * C57BL/6 * SJL

 MP:0002941 increased circulating alanine transaminase level "increased concentration in the blood of this enzyme, which transfers amino groups from l-alanine to 2 ketoglutarate, or the reverse (from l-glutamate to pyruvate); serum concentration is increased in viral hepatitis and myocardial infarction" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Ccm2ltm1Mlkn/Ccm2ltm1Mlkn,Ccm2tm1Mlkn/Ccm2+,Heg1tm1Mlkn/Heg1tm2.1Mlkn,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129 * C57BL/6 * SJL

 MP:0003179 decreased platelet count "fewer than the normal numbers of the non-nucleated cells found in the blood and involved in blood coagulation " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, hdene:Howard Dene , Mouse Genome Informatics Curator, J:93052]
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Allelic Composition: Ccm2ltm1Mlkn/Ccm2ltm1Mlkn,Ccm2tm1Mlkn/Ccm2+,Heg1tm1Mlkn/Heg1tm2.1Mlkn,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129 * C57BL/6 * SJL

 MP:0003572 abnormal uterus development "abnormal morphogenesis of the female muscular organ of gestation" [ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Ccm2ltm1Mlkn/Ccm2ltm1Mlkn,Ccm2tm1Mlkn/Ccm2+,Heg1tm1Mlkn/Heg1tm2.1Mlkn,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129 * C57BL/6 * SJL

 MP:0004514 dystocia "slow or difficult delivery of offspring and/or placenta" [MESH:C13.703.420.288]
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Allelic Composition: Ccm2ltm1Mlkn/Ccm2ltm1Mlkn,Ccm2tm1Mlkn/Ccm2+,Heg1tm1Mlkn/Heg1tm2.1Mlkn,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129 * C57BL/6 * SJL

 MP:0005179 decreased total circulating cholesterol level "less than the normal concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Ccm2ltm1Mlkn/Ccm2ltm1Mlkn,Ccm2tm1Mlkn/Ccm2+,Heg1tm1Mlkn/Heg1tm2.1Mlkn,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129 * C57BL/6 * SJL

 MP:0005185 decreased circulating progesterone level "less than the normal blood concentration of this antiestrogenic steroid" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:66817]
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Allelic Composition: Ccm2ltm1Mlkn/Ccm2ltm1Mlkn,Ccm2tm1Mlkn/Ccm2+,Heg1tm1Mlkn/Heg1tm2.1Mlkn,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129 * C57BL/6 * SJL

 MP:0005343 increased circulating aspartate transaminase level "greater than normal concentration in the blood of this enzyme, which catalyzes the reversible transfer of an amine group from l-glutamic acid to oxaloacetic acid, forming alpha-ketoglutaric acid and l-aspartic acid; aids in diagnosis of viral hepatitis and myocardial infarction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:85204]
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Allelic Composition: Ccm2ltm1Mlkn/Ccm2ltm1Mlkn,Ccm2tm1Mlkn/Ccm2+,Heg1tm1Mlkn/Heg1tm2.1Mlkn,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129 * C57BL/6 * SJL

 MP:0008028 pregnancy-related premature death "death occuring before the normal life span of an organism, occuring during pregnancy, parturition or lactation" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", MGI:hdene "Howard Dene, Mouse Genome Informatics Curator"]
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Allelic Composition: Ccm2ltm1Mlkn/Ccm2ltm1Mlkn,Ccm2tm1Mlkn/Ccm2+,Heg1tm1Mlkn/Heg1tm2.1Mlkn,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129 * C57BL/6 * SJL

 MP:0008257 thin myometrium "reduced thickness of the smooth muscle coat of the uterus, which forms the main mass of the organ and surrounds and supports the endometrium" [MESH:A02.633.570.500, MGI:brs "Beverly Richards-Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ccm2ltm1Mlkn/Ccm2ltm1Mlkn,Ccm2tm1Mlkn/Ccm2+,Heg1tm1Mlkn/Heg1tm2.1Mlkn,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129 * C57BL/6 * SJL

 MP:0013400 abnormal endometrial gland development "aberrant formation or incomplete differentiation of the simple or branched tubular glands found in the mucus membrane of the uterus" [MGI:Anna, PMID:23619340]
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Allelic Composition: Ccm2ltm1Mlkn/Ccm2ltm1Mlkn,Ccm2tm1Mlkn/Ccm2+,Heg1tm1Mlkn/Heg1tm2.1Mlkn,Tg(Tek-cre)1Ywa/0
Genetic Background: involves: 129 * C57BL/6 * SJL

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000001440 Kpnb1 / P70168 / Importin subunit beta-1 / Q14974* / karyopherin subunit beta 1*  / complex
 ENSMUSG00000029027 Dffb / O54788 / DNA fragmentation factor subunit beta / O76075*  / reaction / complex
 ENSMUSG00000028974 Dffa / O54786 / DNA fragmentation factor subunit alpha / O00273*  / reaction / complex






 

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