ENSMUSG00000003731


Mus musculus

Features
Gene ID: ENSMUSG00000003731
  
Biological name :Kpna6
  
Synonyms : Importin subunit alpha-7 / Kpna6 / O35345
  
Possible biological names infered from orthology : karyopherin subunit alpha 6 / O60684
  
Species: Mus musculus
  
Chr. number: 4
Strand: -1
Band: D2.2
Gene start: 129643980
Gene end: 129672767
  
Corresponding Affymetrix probe sets: 10516678 (MoGene1.0st)   1418590_at (Mouse Genome 430 2.0 Array)   1426796_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000003828
Ensembl peptide - ENSMUSP00000099650
Ensembl peptide - ENSMUSP00000114265
NCBI entrez gene - 16650     See in Manteia.
MGI - MGI:1100836
RefSeq - XM_006502814
RefSeq - NM_008468
RefSeq Peptide - NP_032494
swissprot - O35345
swissprot - Q4FJZ2
swissprot - Q8BH30
swissprot - A2ADZ6
Ensembl - ENSMUSG00000003731
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 kpna6ENSDARG00000044980Danio rerio
 KPNA6ENSGALG00000003383Gallus gallus
 KPNA6ENSG00000025800Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Kpna1 / Q60960 / Importin subunit alpha-5 / P52294* / karyopherin subunit alpha 1*ENSMUSG0000002290581
Kpna4 / O35343 / karyopherin (importin) alpha 4 / O00629* / karyopherin subunit alpha 4*ENSMUSG0000002778248
Kpna3 / O35344 / Importin subunit alpha-4 / O00505* / karyopherin subunit alpha 3*ENSMUSG0000002192947
Kpna2 / P52293 / Importin subunit alpha-1 / P52292* / karyopherin subunit alpha 2*ENSMUSG0000001836246
P52293 / Gm10184 / predicted pseudogene 10184 / KPNA2* / P52292* / karyopherin subunit alpha 2*ENSMUSG0000006687846
Kpna7 / C0LLJ0 / Importin subunit alpha-8 / A9QM74* / karyopherin subunit alpha 7*ENSMUSG0000003877035


Protein motifs (from Interpro)
Interpro ID Name
 IPR000225  Armadillo
 IPR002652  Importin-alpha, importin-beta-binding domain
 IPR011989  Armadillo-like helical
 IPR016024  Armadillo-type fold
 IPR024931  Importin subunit alpha
 IPR032413  Atypical Arm repeat


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006606 protein import into nucleus IEA
 biological_processGO:0006607 NLS-bearing protein import into nucleus IBA
 biological_processGO:0015031 protein transport IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IMP
 biological_processGO:0060135 maternal process involved in female pregnancy IMP
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005643 nuclear pore IBA
 cellular_componentGO:0005654 nucleoplasm IBA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IBA
 molecular_functionGO:0005488 binding IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0008139 nuclear localization sequence binding IBA
 molecular_functionGO:0008565 protein transporter activity IEA
 molecular_functionGO:0061608 nuclear import signal receptor activity IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001926 female infertility "inability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:34193]
Show

Allelic Composition: Ptentm2Mak/Ptentm2Mak,Tg(Fabp1-cre)1Jig/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N

Allelic Composition: Kpna6Gt(AJ0609)Wtsi/Kpna6Gt(AJ0609)Wtsi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0003718 maternal effect "expression of a phenotypic trait in an female animal s offspring that is dependent on the maternal genotype" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ptentm2Mak/Ptentm2Mak,Tg(Fabp1-cre)1Jig/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N

 MP:0009661 abnormal pregnancy "any anomaly in the process of maintaining a developing embryo or fetus within the female body from conception to birth" [ISBN:0198542771 "Rugh, Roberts, The Mouse: Its Reproduction and Development", MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ptentm2Mak/Ptentm2Mak,Tg(Fabp1-cre)1Jig/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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