ENSG00000114030


Homo sapiens

Features
Gene ID: ENSG00000114030
  
Biological name :KPNA1
  
Synonyms : karyopherin subunit alpha 1 / KPNA1 / P52294
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 3
Strand: -1
Band: q21.1
Gene start: 122421949
Gene end: 122514945
  
Corresponding Affymetrix probe sets: 202055_at (Human Genome U133 Plus 2.0 Array)   202056_at (Human Genome U133 Plus 2.0 Array)   202057_at (Human Genome U133 Plus 2.0 Array)   202058_s_at (Human Genome U133 Plus 2.0 Array)   202059_s_at (Human Genome U133 Plus 2.0 Array)   213741_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000417166
Ensembl peptide - ENSP00000420013
Ensembl peptide - ENSP00000419890
Ensembl peptide - ENSP00000419257
Ensembl peptide - ENSP00000418394
Ensembl peptide - ENSP00000417319
Ensembl peptide - ENSP00000343701
NCBI entrez gene - 3836     See in Manteia.
OMIM - 600686
RefSeq - XM_017006364
RefSeq - XM_017006363
RefSeq - XM_005247437
RefSeq - XM_011512795
RefSeq - NM_002264
RefSeq - XM_011512797
RefSeq Peptide - NP_002255
swissprot - P52294
swissprot - C9JYI4
swissprot - F2Z3G4
swissprot - C9J352
swissprot - C9J4U1
swissprot - C9JWD9
Ensembl - ENSG00000114030
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 kpna1ENSDARG00000016360Danio rerio
 KPNA1ENSGALG00000014426Gallus gallus
 Kpna1ENSMUSG00000022905Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
KPNA6 / O60684 / karyopherin subunit alpha 6ENSG0000002580081
KPNA5 / O15131 / karyopherin subunit alpha 5ENSG0000019691180
KPNA3 / O00505 / karyopherin subunit alpha 3ENSG0000010275347
KPNA4 / O00629 / karyopherin subunit alpha 4ENSG0000018643247
KPNA2 / P52292 / karyopherin subunit alpha 2ENSG0000018248146
KPNA7 / A9QM74 / karyopherin subunit alpha 7ENSG0000018546740


Protein motifs (from Interpro)
Interpro ID Name
 IPR000225  Armadillo
 IPR002652  Importin-alpha, importin-beta-binding domain
 IPR011989  Armadillo-like helical
 IPR016024  Armadillo-type fold
 IPR024931  Importin subunit alpha
 IPR032413  Atypical Arm repeat


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000018 regulation of DNA recombination TAS
 biological_processGO:0006309 apoptotic DNA fragmentation TAS
 biological_processGO:0006606 protein import into nucleus IEA
 biological_processGO:0006607 NLS-bearing protein import into nucleus TAS
 biological_processGO:0015031 protein transport IEA
 biological_processGO:0016032 viral process IEA
 biological_processGO:0019054 modulation by virus of host process TAS
 biological_processGO:0075733 intracellular transport of virus TAS
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005643 nuclear pore TAS
 cellular_componentGO:0005654 nucleoplasm IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IDA
 cellular_componentGO:0030425 dendrite ISS
 cellular_componentGO:0043657 host cell IEA
 molecular_functionGO:0005488 binding IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0008139 nuclear localization sequence binding TAS
 molecular_functionGO:0008565 protein transporter activity IEA
 molecular_functionGO:0061608 nuclear import signal receptor activity IEA


Pathways (from Reactome)
Pathway description
ISG15 antiviral mechanism
Integration of provirus
Transport of Ribonucleoproteins into the Host Nucleus
NS1 Mediated Effects on Host Pathways
Vpr-mediated nuclear import of PICs
Activation of DNA fragmentation factor


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000108424 KPNB1 / Q14974 / karyopherin subunit beta 1  / complex / reaction
 ENSG00000169598 DFFB / O76075 / DNA fragmentation factor subunit beta  / complex / reaction
 ENSG00000160049 DFFA / O00273 / DNA fragmentation factor subunit alpha  / reaction / complex






 

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