ENSG00000182481


Homo sapiens

Features
Gene ID: ENSG00000182481
  
Biological name :KPNA2
  
Synonyms : karyopherin subunit alpha 2 / KPNA2 / P52292
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 17
Strand: 1
Band: q24.2
Gene start: 68035519
Gene end: 68046842
  
Corresponding Affymetrix probe sets: 201088_at (Human Genome U133 Plus 2.0 Array)   211762_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000463320
Ensembl peptide - ENSP00000438483
Ensembl peptide - ENSP00000332455
Ensembl peptide - ENSP00000463602
Ensembl peptide - ENSP00000462331
NCBI entrez gene - 3838     See in Manteia.
OMIM - 600685
RefSeq - NM_001320611
RefSeq - NM_002266
RefSeq Peptide - NP_001307540
RefSeq Peptide - NP_002257
swissprot - P52292
swissprot - J3KS65
swissprot - J3QL07
swissprot - J3QLL0
Ensembl - ENSG00000182481
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 kpna2ENSDARG00000038066Danio rerio
 KPNA2ENSGALG00000003584Gallus gallus
 Kpna2ENSMUSG00000018362Mus musculus
 P52293ENSMUSG00000066878Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
KPNA7 / A9QM74 / karyopherin subunit alpha 7ENSG0000018546753
KPNA4 / O00629 / karyopherin subunit alpha 4ENSG0000018643250
KPNA3 / O00505 / karyopherin subunit alpha 3ENSG0000010275349
KPNA5 / O15131 / karyopherin subunit alpha 5ENSG0000019691148
KPNA6 / O60684 / karyopherin subunit alpha 6ENSG0000002580047
KPNA1 / P52294 / karyopherin subunit alpha 1ENSG0000011403046


Protein motifs (from Interpro)
Interpro ID Name
 IPR000225  Armadillo
 IPR002652  Importin-alpha, importin-beta-binding domain
 IPR011989  Armadillo-like helical
 IPR016024  Armadillo-type fold
 IPR024931  Importin subunit alpha
 IPR032413  Atypical Arm repeat


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000018 regulation of DNA recombination TAS
 biological_processGO:0006259 DNA metabolic process TAS
 biological_processGO:0006606 protein import into nucleus IEA
 biological_processGO:0006607 NLS-bearing protein import into nucleus IDA
 biological_processGO:0015031 protein transport IEA
 biological_processGO:0016032 viral process IEA
 biological_processGO:0019054 modulation by virus of host process TAS
 biological_processGO:0075733 intracellular transport of virus TAS
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005643 nuclear pore IBA
 cellular_componentGO:0005654 nucleoplasm IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IDA
 cellular_componentGO:0016020 membrane HDA
 cellular_componentGO:0043657 host cell IEA
 molecular_functionGO:0003723 RNA binding HDA
 molecular_functionGO:0005488 binding IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0008139 nuclear localization sequence binding IDA
 molecular_functionGO:0008565 protein transporter activity IEA
 molecular_functionGO:0042826 histone deacetylase binding IPI
 molecular_functionGO:0061608 nuclear import signal receptor activity IEA


Pathways (from Reactome)
Pathway description
ISG15 antiviral mechanism
NS1 Mediated Effects on Host Pathways
Sensing of DNA Double Strand Breaks
Estrogen-dependent gene expression


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000104320 NBN / nibrin / O60934  / reaction / complex






 

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