ENSG00000186432


Homo sapiens

Features
Gene ID: ENSG00000186432
  
Biological name :KPNA4
  
Synonyms : karyopherin subunit alpha 4 / KPNA4 / O00629
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 3
Strand: -1
Band: q25.33
Gene start: 160494995
Gene end: 160565588
  
Corresponding Affymetrix probe sets: 1558383_at (Human Genome U133 Plus 2.0 Array)   209653_at (Human Genome U133 Plus 2.0 Array)   213567_at (Human Genome U133 Plus 2.0 Array)   225267_at (Human Genome U133 Plus 2.0 Array)   225268_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000334373
Ensembl peptide - ENSP00000417172
NCBI entrez gene - 3840     See in Manteia.
OMIM - 602970
RefSeq - NM_002268
RefSeq Peptide - NP_002259
swissprot - O00629
swissprot - H7C4F6
Ensembl - ENSG00000186432
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 kpna4ENSDARG00000023190Danio rerio
 KPNA4ENSGALG00000009549Gallus gallus
 Kpna4ENSMUSG00000027782Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
KPNA3 / O00505 / karyopherin subunit alpha 3ENSG0000010275386
KPNA2 / P52292 / karyopherin subunit alpha 2ENSG0000018248151
KPNA5 / O15131 / karyopherin subunit alpha 5ENSG0000019691149
KPNA6 / O60684 / karyopherin subunit alpha 6ENSG0000002580049
KPNA1 / P52294 / karyopherin subunit alpha 1ENSG0000011403048
KPNA7 / A9QM74 / karyopherin subunit alpha 7ENSG0000018546743


Protein motifs (from Interpro)
Interpro ID Name
 IPR000225  Armadillo
 IPR002652  Importin-alpha, importin-beta-binding domain
 IPR011989  Armadillo-like helical
 IPR016024  Armadillo-type fold
 IPR024931  Importin subunit alpha
 IPR032413  Atypical Arm repeat


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006606 protein import into nucleus IEA
 biological_processGO:0006607 NLS-bearing protein import into nucleus TAS
 biological_processGO:0015031 protein transport IEA
 biological_processGO:0019054 modulation by virus of host process TAS
 biological_processGO:0042542 response to hydrogen peroxide IEA
 biological_processGO:0075733 intracellular transport of virus TAS
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005643 nuclear pore IBA
 cellular_componentGO:0005654 nucleoplasm IBA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IBA
 cellular_componentGO:0031965 nuclear membrane IDA
 cellular_componentGO:0043657 host cell IEA
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0005488 binding IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0008139 nuclear localization sequence binding IBA
 molecular_functionGO:0008565 protein transporter activity IBA
 molecular_functionGO:0061608 nuclear import signal receptor activity IEA


Pathways (from Reactome)
Pathway description
ISG15 antiviral mechanism
NS1 Mediated Effects on Host Pathways


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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