ENSG00000102753


Homo sapiens

Features
Gene ID: ENSG00000102753
  
Biological name :KPNA3
  
Synonyms : karyopherin subunit alpha 3 / KPNA3 / O00505
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 13
Strand: -1
Band: q14.2
Gene start: 49699307
Gene end: 49792921
  
Corresponding Affymetrix probe sets: 221502_at (Human Genome U133 Plus 2.0 Array)   221503_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000393869
Ensembl peptide - ENSP00000261667
NCBI entrez gene - 3839     See in Manteia.
OMIM - 601892
RefSeq - XM_017020561
RefSeq - NM_002267
RefSeq Peptide - NP_002258
swissprot - A0A024RDV7
swissprot - O00505
swissprot - H0Y4S9
Ensembl - ENSG00000102753
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 kpna3ENSDARG00000052641Danio rerio
 KPNA3ENSGALG00000017009Gallus gallus
 Kpna3ENSMUSG00000021929Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
KPNA4 / O00629 / karyopherin subunit alpha 4ENSG0000018643286
KPNA2 / P52292 / karyopherin subunit alpha 2ENSG0000018248150
KPNA1 / P52294 / karyopherin subunit alpha 1ENSG0000011403048
KPNA5 / O15131 / karyopherin subunit alpha 5ENSG0000019691148
KPNA6 / O60684 / karyopherin subunit alpha 6ENSG0000002580048
KPNA7 / A9QM74 / karyopherin subunit alpha 7ENSG0000018546743


Protein motifs (from Interpro)
Interpro ID Name
 IPR000225  Armadillo
 IPR002652  Importin-alpha, importin-beta-binding domain
 IPR011989  Armadillo-like helical
 IPR016024  Armadillo-type fold
 IPR024931  Importin subunit alpha
 IPR032413  Atypical Arm repeat


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006606 protein import into nucleus IEA
 biological_processGO:0006607 NLS-bearing protein import into nucleus TAS
 biological_processGO:0015031 protein transport IEA
 biological_processGO:0016032 viral process IEA
 biological_processGO:0019054 modulation by virus of host process TAS
 biological_processGO:0046718 viral entry into host cell IEA
 biological_processGO:0065003 protein-containing complex assembly TAS
 biological_processGO:0075732 viral penetration into host nucleus IEA
 biological_processGO:0075733 intracellular transport of virus TAS
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005643 nuclear pore TAS
 cellular_componentGO:0005654 nucleoplasm IBA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IBA
 cellular_componentGO:0043657 host cell IEA
 molecular_functionGO:0005488 binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008022 protein C-terminus binding IEA
 molecular_functionGO:0008139 nuclear localization sequence binding TAS
 molecular_functionGO:0008565 protein transporter activity IBA
 molecular_functionGO:0061608 nuclear import signal receptor activity IEA


Pathways (from Reactome)
Pathway description
ISG15 antiviral mechanism
NS1 Mediated Effects on Host Pathways


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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