ENSG00000160049


Homo sapiens

Features
Gene ID: ENSG00000160049
  
Biological name :DFFA
  
Synonyms : DFFA / DNA fragmentation factor subunit alpha / O00273
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 1
Strand: -1
Band: p36.22
Gene start: 10456522
Gene end: 10472526
  
Corresponding Affymetrix probe sets: 203277_at (Human Genome U133 Plus 2.0 Array)   223518_at (Human Genome U133 Plus 2.0 Array)   226116_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000468395
Ensembl peptide - ENSP00000366235
Ensembl peptide - ENSP00000366237
NCBI entrez gene - 1676     See in Manteia.
OMIM - 601882
RefSeq - NM_213566
RefSeq - NM_004401
RefSeq Peptide - NP_004392
RefSeq Peptide - NP_998731
swissprot - O00273
swissprot - A0A024R4H5
swissprot - K7ERT1
Ensembl - ENSG00000160049
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 dffaENSDARG00000055770Danio rerio
 DFFAENSGALG00000002820Gallus gallus
 DffaENSMUSG00000028974Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR003508  CIDE-N domain
 IPR015121  DNA fragmentation factor 45kDa, middle domain
 IPR017299  DNA fragmentation factor subunit alpha
 IPR027296  DNA fragmentation factor 45kDa, C-terminal


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006309 apoptotic DNA fragmentation TAS
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0032076 negative regulation of deoxyribonuclease activity IMP
 biological_processGO:0043065 positive regulation of apoptotic process IEA
 biological_processGO:0061077 chaperone-mediated protein folding IMP
 biological_processGO:0070242 thymocyte apoptotic process IEA
 biological_processGO:1900118 negative regulation of execution phase of apoptosis IDA
 biological_processGO:1902511 negative regulation of apoptotic DNA fragmentation IDA
 cellular_componentGO:0000790 nuclear chromatin IDA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005886 plasma membrane IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0019904 protein domain specific binding IPI
 molecular_functionGO:0044183 protein binding involved in protein folding IPI
 molecular_functionGO:0060703 deoxyribonuclease inhibitor activity IMP


Pathways (from Reactome)
Pathway description
Activation of DNA fragmentation factor


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000108424 KPNB1 / Q14974 / karyopherin subunit beta 1  / reaction / complex
 ENSG00000164305 CASP3 / P42574 / caspase 3  / reaction
 ENSG00000169598 DFFB / O76075 / DNA fragmentation factor subunit beta  / reaction / complex
 ENSG00000114030 KPNA1 / P52294 / karyopherin subunit alpha 1  / reaction / complex
 ENSG00000160049 DFFA / O00273 / DNA fragmentation factor subunit alpha  / reaction / complex






 

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