Manteia - Molecule gene

ENSMUSG00000028974

Mus musculus

Features

Gene ID:	ENSMUSG00000028974

Biological name :	Dffa

Synonyms :	Dffa / DNA fragmentation factor subunit alpha / O54786

Possible biological names infered from orthology :	O00273

Species:	Mus musculus

Chr. number:	4
Strand:	1
Band:	E2
Gene start:	149104146
Gene end:	149120647

Corresponding Affymetrix probe sets:	10510452 (MoGene1.0st) 1450885_at (Mouse Genome 430 2.0 Array) 1457564_at (Mouse Genome 430 2.0 Array)

Cross references:	Ensembl peptide - ENSMUSP00000030816 Ensembl peptide - ENSMUSP00000099505 NCBI entrez gene - 13347 See in Manteia. MGI - MGI:1196227 RefSeq - NM_010044 RefSeq - NM_001025296 RefSeq Peptide - NP_001020467 RefSeq Peptide - NP_034174 swissprot - O54786 swissprot - Q8C535 Ensembl - ENSMUSG00000028974

See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
dffa	ENSDARG00000055770	Danio rerio
DFFA	ENSGALG00000002820	Gallus gallus
DFFA	ENSG00000160049	Homo sapiens

Paralog prediction (from Ensembl)

Paralog name

ID

Similarity(%)

No match

Protein motifs (from Interpro)

Interpro ID	Name
IPR003508	CIDE-N domain
IPR015121	DNA fragmentation factor 45kDa, middle domain
IPR017299	DNA fragmentation factor subunit alpha
IPR027296	DNA fragmentation factor 45kDa, C-terminal

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0006915	apoptotic process	IEA
biological_process	GO:0032076	negative regulation of deoxyribonuclease activity	IEA
biological_process	GO:0043065	positive regulation of apoptotic process	IMP
biological_process	GO:0061077	chaperone-mediated protein folding	IEA
biological_process	GO:0070242	thymocyte apoptotic process	IMP
biological_process	GO:1900118	negative regulation of execution phase of apoptosis	IEA
biological_process	GO:1902511	negative regulation of apoptotic DNA fragmentation	ISO
cellular_component	GO:0000790	nuclear chromatin	IEA
cellular_component	GO:0005622	intracellular	IEA
cellular_component	GO:0005634	nucleus	IEA
cellular_component	GO:0005737	cytoplasm	IEA
cellular_component	GO:0005829	cytosol	IEA
cellular_component	GO:0005886	plasma membrane	IEA
molecular_function	GO:0005515	protein binding	IPI
molecular_function	GO:0019904	protein domain specific binding	IEA
molecular_function	GO:0044183	protein binding involved in protein folding	IEA
molecular_function	GO:0060703	deoxyribonuclease inhibitor activity	IEA

Pathways (from Reactome)

Pathway description

Activation of DNA fragmentation factor

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
MP:0000812	abnormal dentate gyrus morphology	"absence or malformation of one of two interlocking gyri of the hippocampus that contains granule cells, which project to the pyramidal cells and interneurons of the CA3 region of the ammon gyrus" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:38857]	Show Allelic Composition: Nbl1^tm2Rmh/Nbl1^tm2Rmh Genetic Background: either: (involves: 129P2/OlaHsd * 129S6/SvEvTac) or (involves: 129P2/OlaHsd * C57BL/6J)
MP:0001463	abnormal spatial learning	"defects in the abilibity to navigate using behavioraly meaningful locations" [CFG:Center for Functional Genomics , Northwestern University]	Show Allelic Composition: Nbl1^tm2Rmh/Nbl1^tm2Rmh Genetic Background: either: (involves: 129P2/OlaHsd * 129S6/SvEvTac) or (involves: 129P2/OlaHsd * C57BL/6J)
MP:0001648	abnormal apoptosis	"excessive or absent cell death in a particular tissue or cell type" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:25248]	Show Allelic Composition: Nbl1^tm2Rmh/Nbl1^tm2Rmh Genetic Background: either: (involves: 129P2/OlaHsd * 129S6/SvEvTac) or (involves: 129P2/OlaHsd * C57BL/6J)
MP:0006043	decreased apoptosis	"less than normal cell death" [RGD:Rat Genome Database submission, smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Nbl1^tm2Rmh/Nbl1^tm2Rmh Genetic Background: either: (involves: 129P2/OlaHsd * 129S6/SvEvTac) or (involves: 129P2/OlaHsd * C57BL/6J) Allelic Composition: Spout1^tm1Mxu/Spout1⁺,Dffa^tm1Mxu/Dffa^tm1Mxu Genetic Background: involves: 129 * C57BL/6
MP:0008236	decreased susceptibility to neuronal excitotoxicity	"less than normal amount of neuronal cell death following exposure to a neurotoxic compound, such as kaniate-induced neuronal cell death mediated via a glutamate excitotoxic process" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Nbl1^tm2Rmh/Nbl1^tm2Rmh Genetic Background: either: (involves: 129P2/OlaHsd * 129S6/SvEvTac) or (involves: 129P2/OlaHsd * C57BL/6J)

Interacting proteins (from Reactome)

Interactor ID	Name	Interaction type
ENSMUSG00000029027	Dffb / O54788 / DNA fragmentation factor subunit beta / O76075*	/ complex / reaction
ENSMUSG00000001440	Kpnb1 / P70168 / Importin subunit beta-1 / Q14974* / karyopherin subunit beta 1*	/ complex / reaction
ENSMUSG00000028974	Dffa / O54786 / DNA fragmentation factor subunit alpha / O00273*	/ complex / reaction
ENSMUSG00000022905	Kpna1 / Q60960 / Importin subunit alpha-5 / P52294* / karyopherin subunit alpha 1*	/ reaction / complex
ENSMUSG00000031628	Casp3 / P70677 / Caspase-3 Caspase-3 subunit p17 Caspase-3 subunit p12 / P42574* / caspase 3*	/ reaction

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		© Olivier Tassy / Olivier Pourquie 2007-2024 contact: otassy@igbmc.fr