ENSMUSG00000029027


Mus musculus

Features
Gene ID: ENSMUSG00000029027
  
Biological name :Dffb
  
Synonyms : Dffb / DNA fragmentation factor subunit beta / O54788
  
Possible biological names infered from orthology : O76075
  
Species: Mus musculus
  
Chr. number: 4
Strand: -1
Band: E2
Gene start: 153964449
Gene end: 153975126
  
Corresponding Affymetrix probe sets: 10518957 (MoGene1.0st)   1421229_at (Mouse Genome 430 2.0 Array)   1437051_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000030893
Ensembl peptide - ENSMUSP00000151699
NCBI entrez gene - 13368     See in Manteia.
MGI - MGI:1196287
RefSeq - XM_011250184
RefSeq - NM_007859
RefSeq - XM_006538517
RefSeq - XM_011250183
RefSeq Peptide - NP_031885
swissprot - A0A1W2P7L3
swissprot - O54788
Ensembl - ENSMUSG00000029027
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 dffbENSDARG00000009748Danio rerio
 DFFBENSGALG00000036295Gallus gallus
 DFFBENSG00000169598Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR003508  CIDE-N domain
 IPR015311  Apoptosis, DNA fragmentation factor 40kDa


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006308 DNA catabolic process ISO
 biological_processGO:0006309 apoptotic DNA fragmentation IEA
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0030263 apoptotic chromosome condensation ISO
 biological_processGO:0051260 protein homooligomerization ISO
 cellular_componentGO:0000790 nuclear chromatin ISO
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005730 nucleolus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol ISO
 molecular_functionGO:0003677 DNA binding IDA
 molecular_functionGO:0004518 nuclease activity IDA
 molecular_functionGO:0004536 deoxyribonuclease activity ISO
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0019899 enzyme binding ISO
 molecular_functionGO:0019904 protein domain specific binding ISO
 molecular_functionGO:0042802 identical protein binding ISO
 molecular_functionGO:0097718 disordered domain specific binding ISO


Pathways (from Reactome)
Pathway description
Activation of DNA fragmentation factor


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000703 abnormal thymus morphology "anomalous structure or development of the primary lymphoid organ; required for immune system development" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:55400]
Show

Allelic Composition: Dffbtm1Osa/Dffbtm1Osa,Dnase2atm1Osa/Dnase2atm1Osa
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0000706 small thymus "reduced size of the thymus" [J:36561, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:31167]
Show

Allelic Composition: Dffbtm1Osa/Dffbtm1Osa,Dnase2atm1Osa/Dnase2atm1Osa
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
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Allelic Composition: Pdgfatm1Cbet/Pdgfatm1Cbet
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001577 anemia "less than normal levels of red blood cells, hemoglobin or volume of packed red blood cells " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]
Show

Allelic Composition: Dffbtm1Osa/Dffbtm1Osa,Dnase2atm1Osa/Dnase2atm1Osa
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001648 abnormal apoptosis "excessive or absent cell death in a particular tissue or cell type" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:25248]
Show

Allelic Composition: Pdgfatm1Cbet/Pdgfatm1Cbet
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001823 thymus hypoplasia "small size due to reduced cell number in the thymus" [J:23255]
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Allelic Composition: Dffbtm1Osa/Dffbtm1Osa,Dnase2atm1Osa/Dnase2atm1Osa
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002145 abnormal T lymphocyte development "atypical production of or inability to produce mature T cells, and/or accumulation of T cell precursors" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Dffbtm1Osa/Dffbtm1Osa,Dnase2atm1Osa/Dnase2atm1Osa
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0005090 increased double-negative T cells count "greater than expected numbers of the subset of T cells found in the thymus that express neither CD4 nor CD8" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Dffbtm1Osa/Dffbtm1Osa,Dnase2atm1Osa/Dnase2atm1Osa
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0005092 decreased double-positive T cell count "less than the expected number of the subset of T cells found in the thymus that express both CD4 and CD8" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Dffbtm1Osa/Dffbtm1Osa,Dnase2atm1Osa/Dnase2atm1Osa
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000029027 Dffb / O54788 / DNA fragmentation factor subunit beta / O76075*  / complex / reaction / -
 ENSMUSG00000028974 Dffa / O54786 / DNA fragmentation factor subunit alpha / O00273*  / reaction / complex
 ENSMUSG00000022905 Kpna1 / Q60960 / Importin subunit alpha-5 / P52294* / karyopherin subunit alpha 1*  / complex / reaction
 ENSMUSG00000001440 Kpnb1 / P70168 / Importin subunit beta-1 / Q14974* / karyopherin subunit beta 1*  / complex / reaction
 ENSMUSG00000031628 Casp3 / P70677 / Caspase-3 Caspase-3 subunit p17 Caspase-3 subunit p12 / P42574* / caspase 3*  / reaction
 ENSMUSG00000096210 H1f0 / P10922 / Histone H1.0 Histone H1.0, N-terminally processed / P07305* / H1 histone family member 0*  / complex / reaction






 

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