ENSMUSG00000096210


Mus musculus

Features
Gene ID: ENSMUSG00000096210
  
Biological name :H1f0
  
Synonyms : H1f0 / Histone H1.0 Histone H1.0, N-terminally processed / P10922
  
Possible biological names infered from orthology : H1 histone family member 0 / P07305
  
Species: Mus musculus
  
Chr. number: 15
Strand: 1
Band: E1
Gene start: 79028450
Gene end: 79030504
  
Corresponding Affymetrix probe sets: 10425207 (MoGene1.0st)   1423702_at (Mouse Genome 430 2.0 Array)   1450522_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000137309
NCBI entrez gene - 14958     See in Manteia.
MGI - MGI:95893
RefSeq - NM_008197
RefSeq Peptide - NP_032223
swissprot - P10922
Ensembl - ENSMUSG00000096210
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 h1f0ENSDARG00000038559Danio rerio
 H1F0ENSGALG00000044240Gallus gallus
 H1F0ENSG00000189060Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR005818  Linker histone H1/H5, domain H15
 IPR005819  Histone H5
 IPR036388  Winged helix-like DNA-binding domain superfamily
 IPR036390  Winged helix DNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006334 nucleosome assembly IEA
 cellular_componentGO:0000786 nucleosome IEA
 cellular_componentGO:0000790 nuclear chromatin IEA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005694 chromosome IEA
 cellular_componentGO:0005719 nuclear euchromatin IEA
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0015629 actin cytoskeleton IEA
 cellular_componentGO:0016604 nuclear body IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003680 AT DNA binding IMP
 molecular_functionGO:0003690 double-stranded DNA binding IMP
 molecular_functionGO:0031490 chromatin DNA binding IEA


Pathways (from Reactome)
Pathway description
Activation of DNA fragmentation factor
Formation of Senescence-Associated Heterochromatin Foci (SAHF)


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000706 small thymus "reduced size of the thymus" [J:36561, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:31167]
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Allelic Composition: H1f0tm1Ais/H1f0tm1Ais,Hist1h1ctm2Ais/Hist1h1ctm2Ais,Hist1h1etm2Ais/Hist1h1etm2Ais
Genetic Background: involves: 129/Sv * C57BL/6 * SJL

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
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Allelic Composition: H1f0tm1Ais/H1f0tm1Ais,Hist1h1ctm2Ais/Hist1h1ctm2Ais,Hist1h1etm2Ais/Hist1h1etm2Ais
Genetic Background: involves: 129/Sv * C57BL/6 * SJL

 MP:0001921 reduced fertility "diminished ability to produce live offspring" [J:65030]
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Allelic Composition: H1f0tm1Ais/H1f0tm1Ais,Hist1h1ctm2Ais/Hist1h1ctm2Ais,Hist1h1etm2Ais/Hist1h1etm2Ais
Genetic Background: involves: 129/Sv * C57BL/6 * SJL

 MP:0002085 abnormal embryonic tissue morphology "structural abnormality or development of any embryonic tissue resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Tlr2tm1Kir/Tlr2tm1Kir
Genetic Background: either: (involves: 129/Sv * C57BL/6) or (involves: 129/Sv * C57BL/6 * C57BL/6J)

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Acrtm1Wen/Acrtm1Wen,Hist1h1atm1Drab/Hist1h1atm1Drab,Tnp2tm1Wen/Tnp2tm1Wen
Genetic Background: involves: 129 * C57BL/6J * CD-1

Allelic Composition: H1f0tm1Ais/H1f0tm1Ais,Hist1h1dtm1Ais/Hist1h1dtm1Ais
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: H1f0tm1Ais/H1f0tm1Ais,Hist1h1ctm1Ais/Hist1h1ctm1Ais
Genetic Background: involves: 129P2/OlaHsd * C57BL

Allelic Composition: H1f0tm1Ais/H1f0tm1Ais
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0011091 complete prenatal lethality "death of all organisms of a given genotype in a population between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
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Allelic Composition: Tlr2tm1Kir/Tlr2tm1Kir
Genetic Background: either: (involves: 129/Sv * C57BL/6) or (involves: 129/Sv * C57BL/6 * C57BL/6J)

 MP:0011101 partial prenatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
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Allelic Composition: H1f0tm1Ais/H1f0tm1Ais,Hist1h1ctm2Ais/Hist1h1ctm2Ais,Hist1h1etm2Ais/Hist1h1etm2Ais
Genetic Background: involves: 129/Sv * C57BL/6 * SJL

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000029027 Dffb / O54788 / DNA fragmentation factor subunit beta / O76075*  / reaction / complex
 ENSMUSG00000039473 Ubn1 / Q4G0F8 / ubinuclein 1 / Q9NPG3*  / reaction
 ENSMUSG00000056758 Hmga2 / P52927 / high mobility group AT-hook 2 / P52926*  / reaction
 ENSMUSG00000022702 Hira / Q61666 / Protein HIRA / P54198* / histone cell cycle regulator*  / reaction
 ENSMUSG00000019857 Asf1a / Q9CQE6 / Histone chaperone ASF1A / Q9Y294* / anti-silencing function 1A histone chaperone*  / reaction
 ENSMUSG00000046711 Hmga1 / P17095 / High mobility group protein HMG-I/HMG-Y / P17096* / high mobility group AT-hook 1*  / reaction






 

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