ENSMUSG00000046711


Mus musculus

Features
Gene ID: ENSMUSG00000046711
  
Biological name :Hmga1
  
Synonyms : High mobility group protein HMG-I/HMG-Y / Hmga1 / P17095
  
Possible biological names infered from orthology : high mobility group AT-hook 1 / P17096
  
Species: Mus musculus
  
Chr. number: 17
Strand: 1
Band: A3.3
Gene start: 27556620
Gene end: 27563674
  
Corresponding Affymetrix probe sets: 10383479 (MoGene1.0st)   10443195 (MoGene1.0st)   1416184_s_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000114101
Ensembl peptide - ENSMUSP00000110538
Ensembl peptide - ENSMUSP00000113011
Ensembl peptide - ENSMUSP00000113015
Ensembl peptide - ENSMUSP00000113068
Ensembl peptide - ENSMUSP00000113916
NCBI entrez gene - 15361     See in Manteia.
MGI - MGI:96160
RefSeq - NM_001166541
RefSeq - NM_001166542
RefSeq - NM_001166543
RefSeq - NM_001166544
RefSeq - NM_001166546
RefSeq - NM_016660
RefSeq - NM_001166545
RefSeq - NM_001025427
RefSeq - NM_001039356
RefSeq - NM_001166535
RefSeq - NM_001166536
RefSeq - NM_001166537
RefSeq - NM_001166539
RefSeq - NM_001166540
RefSeq Peptide - NP_001020598
RefSeq Peptide - NP_001034445
RefSeq Peptide - NP_001160007
RefSeq Peptide - NP_001160008
RefSeq Peptide - NP_001160009
RefSeq Peptide - NP_001160011
RefSeq Peptide - NP_001160012
RefSeq Peptide - NP_001160013
RefSeq Peptide - NP_001160014
RefSeq Peptide - NP_001160015
RefSeq Peptide - NP_001160016
RefSeq Peptide - NP_001160017
RefSeq Peptide - NP_001160018
RefSeq Peptide - NP_057869
swissprot - P17095
swissprot - Q3TVP0
swissprot - Q566K0
Ensembl - ENSMUSG00000046711
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 hmga1aENSDARG00000028335Danio rerio
 hmga1bENSDARG00000070951Danio rerio
 HMGA1ENSGALG00000030396Gallus gallus
 HMGA1ENSG00000137309Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Hmga1b / P17095 / High mobility group protein HMG-I/HMG-Y / HMGA1* / P17096* / high mobility group AT-hook 1*ENSMUSG00000078249100


Protein motifs (from Interpro)
Interpro ID Name
 IPR000116  High mobility group protein HMGA
 IPR000637  HMG-I/HMG-Y, DNA-binding, conserved site
 IPR017956  AT hook, DNA-binding motif
 IPR031079  High mobility group protein HMGA1, mammal


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006284 base-excision repair IBA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0007283 spermatogenesis IMP
 biological_processGO:0008285 negative regulation of cell proliferation ISS
 biological_processGO:0035986 senescence-associated heterochromatin focus assembly ISS
 biological_processGO:0045892 negative regulation of transcription, DNA-templated ISS
 biological_processGO:0045893 positive regulation of transcription, DNA-templated ISS
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IDA
 biological_processGO:0090402 oncogene-induced cell senescence ISS
 biological_processGO:2000774 positive regulation of cellular senescence ISS
 cellular_componentGO:0000785 chromatin IEA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005694 chromosome IEA
 cellular_componentGO:0035985 senescence-associated heterochromatin focus ISS
 cellular_componentGO:0090575 RNA polymerase II transcription factor complex IDA
 molecular_functionGO:0001077 transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding IDA
 molecular_functionGO:0001158 enhancer sequence-specific DNA binding ISO
 molecular_functionGO:0001205 transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific DNA binding IDA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003680 AT DNA binding IDA
 molecular_functionGO:0003682 chromatin binding IDA
 molecular_functionGO:0003906 DNA-(apurinic or apyrimidinic site) endonuclease activity IBA
 molecular_functionGO:0008134 transcription factor binding ISS
 molecular_functionGO:0019899 enzyme binding ISO
 molecular_functionGO:0030374 nuclear receptor transcription coactivator activity ISS
 molecular_functionGO:0042974 retinoic acid receptor binding ISS
 molecular_functionGO:0042975 peroxisome proliferator activated receptor binding ISS
 molecular_functionGO:0046965 retinoid X receptor binding ISS
 molecular_functionGO:0051575 5"-deoxyribose-5-phosphate lyase activity ISO


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000688 lymphoid hyperplasia "increased cell number in lymphatic tissues" [J:62478]
Show

Allelic Composition: Erbb3tm2Cbm/Erbb3tm2Cbm
Genetic Background: involves: 129P2/OlaHsd

 MP:0000691 enlarged spleen "increased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Erbb3tm2Cbm/Erbb3tm2Cbm
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Hmga1tm1Afus/Hmga1+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0001147 small testis "reduced size of the male reproductive glands" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:58959]
Show

Allelic Composition: Ctnnb1tm1Mmt/Ctnnb1+,Tg(Pou3f4-cre)32Cren/?
Genetic Background: involves: 129X1/SvJ

 MP:0001153 small seminiferous tubules "reduced diameter of the tubules in the testes where spermatogenesis occurs" [J:50844]
Show

Allelic Composition: Ctnnb1tm1Mmt/Ctnnb1+,Tg(Pou3f4-cre)32Cren/?
Genetic Background: involves: 129X1/SvJ

 MP:0001156 abnormal spermatogenesis "incomplete maturation or aberrant formation of the male gametes" [J:58959]
Show

Allelic Composition: Ctnnb1tm1Mmt/Ctnnb1+,Tg(Pou3f4-cre)32Cren/?
Genetic Background: involves: 129X1/SvJ

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Erbb3tm2Cbm/Erbb3tm2Cbm
Genetic Background: involves: 129P2/OlaHsd

 MP:0001539 decreased number of caudal vertebrae "reduced number of the bony segments of the tail" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Golga3tm1b(EUCOMM)Hmgu/Golga3tm1b(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Golga3tm1b(EUCOMM)Hmgu/H

 MP:0001625 cardiac hypertrophy "an increase in size of the cardiac tissue, not due to increased cell number " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Erbb3tm2Cbm/Erbb3tm2Cbm
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Hmga1tm1Afus/Hmga1+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0001925 male infertility "inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
Show

Allelic Composition: Ctnnb1tm1Mmt/Ctnnb1+,Tg(Pou3f4-cre)32Cren/?
Genetic Background: involves: 129X1/SvJ

 MP:0002023 B cell derived lymphoma "heterogeneous lymphoid tumors generally expressing one or more B-cell antigens or representing malignant transformations of B-lymphocytes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Erbb3tm2Cbm/Erbb3tm2Cbm
Genetic Background: involves: 129P2/OlaHsd

 MP:0002026 leukemia "progressive proliferation of abnormal leukocytes in hematopoietic tissues, organs and blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:18542]
Show

Allelic Composition: Erbb3tm2Cbm/Erbb3tm2Cbm
Genetic Background: involves: 129P2/OlaHsd

 MP:0002216 abnormal seminiferous tubule morphology "malformation of the tubules in the testes where spermatogenesis occurs" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ctnnb1tm1Mmt/Ctnnb1+,Tg(Pou3f4-cre)32Cren/?
Genetic Background: involves: 129X1/SvJ

 MP:0002625 left ventricle hypertrophy "increased size of the left ventricle" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Erbb3tm2Cbm/Erbb3tm2Cbm
Genetic Background: involves: 129P2/OlaHsd

 MP:0002727 decreased circulating insulin level "less than normal levels of insulin in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, dlb:Donna Burkart , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ptk2tm1.2Guan/Ptk2tm1.2Guan
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Hmga1tm1Brun/Hmga1+
Genetic Background: Not Specified

 MP:0002784 abnormal Sertoli cell morphology "malformation of the cells of the seminiferous tubules that create the blood-testes barrier and enable spermatogenesis" [J:65900, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ctnnb1tm1Mmt/Ctnnb1+,Tg(Pou3f4-cre)32Cren/?
Genetic Background: involves: 129X1/SvJ

 MP:0002891 increased insulin sensitivity "greater ability to clear glucose from the bloodstream when given insulin than normal; can result in hypoglycemia" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Ptk2tm1.2Guan/Ptk2tm1.2Guan
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Hmga1tm1Brun/Hmga1+
Genetic Background: Not Specified

 MP:0003059 decreased insulin secretion "less than normal release of this hormone secreted by beta cells of the pancreas, that promotes glucose utilization, protein synthesis, and the formation and storage of neutral lipids " [MeSH:National Library of Medicine - Medical Subject Headings, 2003, RGD:Rat Genome Database submission]
Show

Allelic Composition: Ptk2tm1.2Guan/Ptk2tm1.2Guan
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Hmga1tm1Brun/Hmga1+
Genetic Background: Not Specified

 MP:0004901 decreased male germ cell number "reduced numbers of male germ cells whether they are undifferentiated or fully differentiated" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ctnnb1tm1Mmt/Ctnnb1+,Tg(Pou3f4-cre)32Cren/?
Genetic Background: involves: 129X1/SvJ

 MP:0004930 small epididymis "decrease in the average size of the elongated structure connected to the posterior surface of the testis that transports, stores, and matures spermatozoa between testis and vas deferens" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ctnnb1tm1Mmt/Ctnnb1+,Tg(Pou3f4-cre)32Cren/?
Genetic Background: involves: 129X1/SvJ

 MP:0005159 azoospermia "absence of living spermatozoa " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Ctnnb1tm1Mmt/Ctnnb1+,Tg(Pou3f4-cre)32Cren/?
Genetic Background: involves: 129X1/SvJ

 MP:0005215 abnormal islet of Langerhans morphology "anomalous morphology of these structures that are scattered throughout the pancreas and comprise its endocrine portion; within each islet there are three cell types: alpha, beta, and delta " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Ptk2tm1.2Guan/Ptk2tm1.2Guan
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0005293 impaired glucose tolerance "less than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin resistance; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Ptk2tm1.2Guan/Ptk2tm1.2Guan
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Hmga1tm1Brun/Hmga1+
Genetic Background: Not Specified

 MP:0005329 abnormal cardiac muscle morphology "anomalous structure of the involuntary muscle comprising the myocardium " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Erbb3tm2Cbm/Erbb3tm2Cbm
Genetic Background: involves: 129P2/OlaHsd

 MP:0005331 insulin resistance "diminished effectiveness of insulin in lowering plasma glucose levels" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:84260, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ptk2tm1.2Guan/Ptk2tm1.2Guan
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Hmga1tm1Brun/Hmga1+
Genetic Background: Not Specified

 MP:0009172 small pancreatic islets "decrease in the size of the clusters of hormone-producing cells that are scattered throughout the pancreas" [MA:0000127, MESH:A03.734.414]
Show

Allelic Composition: Ptk2tm1.2Guan/Ptk2tm1.2Guan
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0010301 increased stomach tumor incidence "greater than the expected number of neoplasms in the gastric tissue usually in the form of a distinct mass, in a specific population in a given time period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Artm1Jdz/Y,Tg(Pbsn-cre)20Fwan/?
Genetic Background: involves: 129X1/SvJ * C57BL/6J * FVB/NCrl

 MP:0010373 myeloid hyperplasia "greater than normal number of nucleated cells of the myeloid lineage (a monocyte, granulocyte, or mast cell), found in blood or other tissue" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Erbb3tm2Cbm/Erbb3tm2Cbm
Genetic Background: involves: 129P2/OlaHsd

 MP:0011110 partial preweaning lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Golga3tm1b(EUCOMM)Hmgu/Golga3tm1b(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Golga3tm1b(EUCOMM)Hmgu/H

 MP:0011750 abnormal seminiferous tubule epithelium morphology "any structural anomaly of the stratified epithelial lining of the seminiferous tubules, consisting of the developing spermatozoa and the supporting Sertoli cells, which are tall, columnar type cells that line the tubule" [MGI:csmith]
Show

Allelic Composition: Ctnnb1tm1Mmt/Ctnnb1+,Tg(Pou3f4-cre)32Cren/?
Genetic Background: involves: 129X1/SvJ

 MP:0011967 increased or absent threshold for auditory brainstem response "increase in the value at which one or more sound frequencies or broadband clicks first elicits a recordable response generated by electrical activity of neurons in the ascending auditory system, or complete lack of a recordable response at any frequency or broadband click" [MGI:csmith]
Show

Allelic Composition: Golga3tm1b(EUCOMM)Hmgu/Golga3tm1b(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Golga3tm1b(EUCOMM)Hmgu/H

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000019857 Asf1a / Q9CQE6 / Histone chaperone ASF1A / Q9Y294* / anti-silencing function 1A histone chaperone*  / reaction / complex
 ENSMUSG00000039473 Ubn1 / Q4G0F8 / ubinuclein 1 / Q9NPG3*  / complex / reaction
 ENSMUSG00000022702 Hira / Q61666 / Protein HIRA / P54198* / histone cell cycle regulator*  / complex / reaction
 ENSMUSG00000056758 Hmga2 / P52927 / high mobility group AT-hook 2 / P52926*  / complex / reaction
 ENSMUSG00000096210 H1f0 / P10922 / Histone H1.0 Histone H1.0, N-terminally processed / P07305* / H1 histone family member 0*  / reaction






 

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