ENSG00000137309


Homo sapiens

Features
Gene ID: ENSG00000137309
  
Biological name :HMGA1
  
Synonyms : high mobility group AT-hook 1 / HMGA1 / P17096
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 6
Strand: 1
Band: p21.31
Gene start: 34236873
Gene end: 34246231
  
Corresponding Affymetrix probe sets: 206074_s_at (Human Genome U133 Plus 2.0 Array)   210457_x_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000308227
Ensembl peptide - ENSP00000363230
Ensembl peptide - ENSP00000385693
Ensembl peptide - ENSP00000288245
Ensembl peptide - ENSP00000399888
NCBI entrez gene - 3159     See in Manteia.
OMIM - 600701
RefSeq - NM_002131
RefSeq - NM_145899
RefSeq - NM_145901
RefSeq - NM_145903
RefSeq - NM_145905
RefSeq - NM_145902
RefSeq - NM_001319077
RefSeq - NM_001319078
RefSeq - NM_001319079
RefSeq - NM_001319080
RefSeq - NM_001319081
RefSeq - NM_001319082
RefSeq Peptide - NP_001306006
RefSeq Peptide - NP_001306007
RefSeq Peptide - NP_001306008
RefSeq Peptide - NP_001306009
RefSeq Peptide - NP_001306010
RefSeq Peptide - NP_001306011
RefSeq Peptide - NP_002122
RefSeq Peptide - NP_665906
RefSeq Peptide - NP_665908
RefSeq Peptide - NP_665909
RefSeq Peptide - NP_665910
RefSeq Peptide - NP_665912
swissprot - P17096
swissprot - Q5T6U8
Ensembl - ENSG00000137309
  
Related genetic diseases (OMIM): 125853 - {Diabetes mellitus, noninsulin-dependent, susceptibility to}, 125853

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 hmga1aENSDARG00000028335Danio rerio
 hmga1bENSDARG00000070951Danio rerio
 HMGA1ENSGALG00000030396Gallus gallus
 Hmga1ENSMUSG00000046711Mus musculus
 Hmga1bENSMUSG00000078249Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR000116  High mobility group protein HMGA
 IPR000637  HMG-I/HMG-Y, DNA-binding, conserved site
 IPR017956  AT hook, DNA-binding motif
 IPR031079  High mobility group protein HMGA1, mammal


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006268 DNA unwinding involved in DNA replication NAS
 biological_processGO:0006284 base-excision repair IBA
 biological_processGO:0006337 nucleosome disassembly TAS
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated TAS
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0008285 negative regulation of cell proliferation IMP
 biological_processGO:0009615 response to virus IEP
 biological_processGO:0016032 viral process IEA
 biological_processGO:0031936 negative regulation of chromatin silencing TAS
 biological_processGO:0035986 senescence-associated heterochromatin focus assembly IDA
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IMP
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IMP
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II ISS
 biological_processGO:0051169 nuclear transport TAS
 biological_processGO:0065003 protein-containing complex assembly TAS
 biological_processGO:0075713 establishment of integrated proviral latency TAS
 biological_processGO:0090402 oncogene-induced cell senescence IDA
 biological_processGO:2000774 positive regulation of cellular senescence IMP
 cellular_componentGO:0000785 chromatin IEA
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005667 transcription factor complex TAS
 cellular_componentGO:0005694 chromosome IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005925 focal adhesion HDA
 cellular_componentGO:0035985 senescence-associated heterochromatin focus IDA
 cellular_componentGO:0090575 RNA polymerase II transcription factor complex ISS
 molecular_functionGO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding ISM
 molecular_functionGO:0001158 enhancer sequence-specific DNA binding IDA
 molecular_functionGO:0001205 transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific DNA binding ISS
 molecular_functionGO:0003677 DNA binding TAS
 molecular_functionGO:0003680 AT DNA binding IDA
 molecular_functionGO:0003682 chromatin binding ISS
 molecular_functionGO:0003700 DNA-binding transcription factor activity IBA
 molecular_functionGO:0003906 DNA-(apurinic or apyrimidinic site) endonuclease activity IBA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008134 transcription factor binding IDA
 molecular_functionGO:0019899 enzyme binding IPI
 molecular_functionGO:0030374 nuclear receptor transcription coactivator activity IMP
 molecular_functionGO:0042974 retinoic acid receptor binding IDA
 molecular_functionGO:0042975 peroxisome proliferator activated receptor binding IDA
 molecular_functionGO:0046965 retinoid X receptor binding IDA


Pathways (from Reactome)
Pathway description
Integration of provirus
2-LTR circle formation
Integration of viral DNA into host genomic DNA
Autointegration results in viral DNA circles
APOBEC3G mediated resistance to HIV-1 infection
Vpr-mediated nuclear import of PICs
Formation of Senescence-Associated Heterochromatin Foci (SAHF)


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000100084 HIRA / P54198 / histone cell cycle regulator  / reaction / complex
 ENSG00000164985 PSIP1 / O75475 / PC4 and SFRS1 interacting protein 1  / reaction / complex
 ENSG00000099991 CABIN1 / Q9Y6J0 / calcineurin binding protein 1  / complex / reaction
 ENSG00000175334 BANF1 / O75531 / barrier to autointegration factor 1  / reaction / complex
 ENSG00000111875 ASF1A / Q9Y294 / anti-silencing function 1A histone chaperone  / complex / reaction
 ENSG00000118900 UBN1 / Q9NPG3 / ubinuclein 1  / reaction / complex
 ENSG00000189060 H1F0 / P07305 / H1 histone family member 0  / reaction
 ENSG00000149948 HMGA2 / P52926 / high mobility group AT-hook 2  / reaction / complex






 

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