ENSMUSG00000078249


Mus musculus

Features
Gene ID: ENSMUSG00000078249
  
Biological name :Hmga1b
  
Synonyms : High mobility group protein HMG-I/HMG-Y / Hmga1b / P17095
  
Possible biological names infered from orthology : high mobility group AT-hook 1 / HMGA1 / P17096
  
Species: Mus musculus
  
Chr. number: 11
Strand: 1
Band: E2
Gene start: 120762794
Gene end: 120764419
  
Corresponding Affymetrix probe sets: 10383479 (MoGene1.0st)   1416184_s_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000100667
Ensembl peptide - ENSMUSP00000137252
NCBI entrez gene - 111241     See in Manteia.
MGI - MGI:96161
RefSeq - NM_001166476
RefSeq - NM_001166477
RefSeq Peptide - NP_001159948
RefSeq Peptide - NP_001159949
swissprot - Q566K0
swissprot - P17095
swissprot - J3QK51
Ensembl - ENSMUSG00000078249
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 hmga1aENSDARG00000028335Danio rerio
 hmga1bENSDARG00000070951Danio rerio
 HMGA1ENSGALG00000030396Gallus gallus
 HMGA1ENSG00000137309Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Hmga1 / P17095 / High mobility group protein HMG-I/HMG-Y / P17096* / high mobility group AT-hook 1*ENSMUSG00000046711100


Protein motifs (from Interpro)
Interpro ID Name
 IPR000116  High mobility group protein HMGA
 IPR000637  HMG-I/HMG-Y, DNA-binding, conserved site
 IPR017956  AT hook, DNA-binding motif
 IPR031079  High mobility group protein HMGA1, mammal


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006284 base-excision repair IBA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0007283 spermatogenesis IMP
 biological_processGO:0008285 negative regulation of cell proliferation ISS
 biological_processGO:0035986 senescence-associated heterochromatin focus assembly ISS
 biological_processGO:0045892 negative regulation of transcription, DNA-templated ISS
 biological_processGO:0045893 positive regulation of transcription, DNA-templated ISS
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IDA
 biological_processGO:0090402 oncogene-induced cell senescence ISS
 biological_processGO:2000774 positive regulation of cellular senescence ISS
 cellular_componentGO:0000785 chromatin IEA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005694 chromosome IEA
 cellular_componentGO:0035985 senescence-associated heterochromatin focus ISO
 cellular_componentGO:0090575 RNA polymerase II transcription factor complex IDA
 molecular_functionGO:0001077 transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding IDA
 molecular_functionGO:0001158 enhancer sequence-specific DNA binding ISO
 molecular_functionGO:0001205 transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific DNA binding IDA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003680 AT DNA binding ISO
 molecular_functionGO:0003682 chromatin binding IDA
 molecular_functionGO:0003906 DNA-(apurinic or apyrimidinic site) endonuclease activity ISO
 molecular_functionGO:0008134 transcription factor binding ISO
 molecular_functionGO:0019899 enzyme binding ISO
 molecular_functionGO:0030374 nuclear receptor transcription coactivator activity ISO
 molecular_functionGO:0042974 retinoic acid receptor binding ISO
 molecular_functionGO:0042975 peroxisome proliferator activated receptor binding ISO
 molecular_functionGO:0046965 retinoid X receptor binding ISO
 molecular_functionGO:0051575 5"-deoxyribose-5-phosphate lyase activity ISO


Pathways (from Reactome)
Pathway description
Formation of Senescence-Associated Heterochromatin Foci (SAHF)


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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