ENSMUSG00000056758


Mus musculus

Features
Gene ID: ENSMUSG00000056758
  
Biological name :Hmga2
  
Synonyms : high mobility group AT-hook 2 / Hmga2 / P52927
  
Possible biological names infered from orthology : P52926
  
Species: Mus musculus
  
Chr. number: 10
Strand: -1
Band: D2
Gene start: 120361275
Gene end: 120476469
  
Corresponding Affymetrix probe sets: 10372796 (MoGene1.0st)   1422851_at (Mouse Genome 430 2.0 Array)   1446196_at (Mouse Genome 430 2.0 Array)   1450780_s_at (Mouse Genome 430 2.0 Array)   1450781_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000072556
Ensembl peptide - ENSMUSP00000123998
NCBI entrez gene - 15364     See in Manteia.
MGI - MGI:101761
RefSeq - XM_006513251
RefSeq - NM_001347170
RefSeq - NM_010441
RefSeq Peptide - NP_034571
RefSeq Peptide - NP_001334099
swissprot - P52927
swissprot - Q6NSP9
Ensembl - ENSMUSG00000056758
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 hmga2ENSDARG00000069912Danio rerio
 si:ch211-161c3.6ENSDARG00000078781Danio rerio
 HMGA2ENSGALG00000009875Gallus gallus
 HMGA2ENSG00000149948Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR000116  High mobility group protein HMGA
 IPR017956  AT hook, DNA-binding motif


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II ISS
 biological_processGO:0001837 epithelial to mesenchymal transition ISS
 biological_processGO:0002062 chondrocyte differentiation ISS
 biological_processGO:0003131 mesodermal-endodermal cell signaling ISS
 biological_processGO:0006284 base-excision repair IBA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0007095 mitotic G2 DNA damage checkpoint ISS
 biological_processGO:0007283 spermatogenesis IMP
 biological_processGO:0008283 cell proliferation IMP
 biological_processGO:0008284 positive regulation of cell proliferation IMP
 biological_processGO:0008584 male gonad development IMP
 biological_processGO:0010564 regulation of cell cycle process IDA
 biological_processGO:0010628 positive regulation of gene expression IMP
 biological_processGO:0021846 cell proliferation in forebrain IMP
 biological_processGO:0021983 pituitary gland development IMP
 biological_processGO:0030178 negative regulation of Wnt signaling pathway IMP
 biological_processGO:0030261 chromosome condensation IEA
 biological_processGO:0030325 adrenal gland development IMP
 biological_processGO:0031052 chromosome breakage ISS
 biological_processGO:0031507 heterochromatin assembly ISS
 biological_processGO:0035019 somatic stem cell population maintenance IMP
 biological_processGO:0035978 histone H2A-S139 phosphorylation ISS
 biological_processGO:0035986 senescence-associated heterochromatin focus assembly ISS
 biological_processGO:0035987 endodermal cell differentiation ISS
 biological_processGO:0035988 chondrocyte proliferation ISS
 biological_processGO:0040008 regulation of growth IEA
 biological_processGO:0040018 positive regulation of multicellular organism growth IMP
 biological_processGO:0042769 DNA damage response, detection of DNA damage ISS
 biological_processGO:0043065 positive regulation of apoptotic process ISS
 biological_processGO:0043066 negative regulation of apoptotic process ISS
 biological_processGO:0043392 negative regulation of DNA binding ISS
 biological_processGO:0043922 negative regulation by host of viral transcription ISS
 biological_processGO:0045444 fat cell differentiation ISS
 biological_processGO:0045766 positive regulation of angiogenesis IMP
 biological_processGO:0045869 negative regulation of single stranded viral RNA replication via double stranded DNA intermediate ISS
 biological_processGO:0045892 negative regulation of transcription, DNA-templated ISS
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II ISS
 biological_processGO:0048333 mesodermal cell differentiation ISS
 biological_processGO:0048712 negative regulation of astrocyte differentiation IDA
 biological_processGO:0048762 mesenchymal cell differentiation ISS
 biological_processGO:0051301 cell division IEA
 biological_processGO:0051321 meiotic cell cycle IEA
 biological_processGO:0060123 regulation of growth hormone secretion IMP
 biological_processGO:0060428 lung epithelium development IMP
 biological_processGO:0060441 epithelial tube branching involved in lung morphogenesis IMP
 biological_processGO:0060501 positive regulation of epithelial cell proliferation involved in lung morphogenesis IMP
 biological_processGO:0060612 adipose tissue development IMP
 biological_processGO:0060613 fat pad development IGI
 biological_processGO:0071158 positive regulation of cell cycle arrest ISS
 biological_processGO:0071864 positive regulation of cell proliferation in bone marrow IMP
 biological_processGO:0090276 regulation of peptide hormone secretion IMP
 biological_processGO:0090402 oncogene-induced cell senescence ISS
 biological_processGO:2000036 regulation of stem cell population maintenance ISS
 biological_processGO:2000648 positive regulation of stem cell proliferation ISS
 biological_processGO:2000679 positive regulation of transcription regulatory region DNA binding ISS
 biological_processGO:2000685 positive regulation of cellular response to X-ray ISS
 biological_processGO:2000773 negative regulation of cellular senescence IMP
 biological_processGO:2000774 positive regulation of cellular senescence ISS
 biological_processGO:2001022 positive regulation of response to DNA damage stimulus ISS
 biological_processGO:2001033 negative regulation of double-strand break repair via nonhomologous end joining ISS
 biological_processGO:2001038 regulation of cellular response to drug ISS
 cellular_componentGO:0000228 nuclear chromosome IDA
 cellular_componentGO:0000785 chromatin IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0032993 protein-DNA complex ISS
 cellular_componentGO:0035985 senescence-associated heterochromatin focus ISS
 cellular_componentGO:0071141 SMAD protein complex ISS
 molecular_functionGO:0001047 core promoter binding ISS
 molecular_functionGO:0001077 transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding IDA
 molecular_functionGO:0001078 transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding ISS
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003680 AT DNA binding ISS
 molecular_functionGO:0003906 DNA-(apurinic or apyrimidinic site) endonuclease activity IBA
 molecular_functionGO:0004677 DNA-dependent protein kinase activity ISS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008301 DNA binding, bending ISS
 molecular_functionGO:0031492 nucleosomal DNA binding ISS
 molecular_functionGO:0035497 cAMP response element binding ISS
 molecular_functionGO:0035500 MH2 domain binding ISS
 molecular_functionGO:0035501 MH1 domain binding ISS
 molecular_functionGO:0044212 transcription regulatory region DNA binding ISS
 molecular_functionGO:0051575 5"-deoxyribose-5-phosphate lyase activity ISS
 molecular_functionGO:0070742 C2H2 zinc finger domain binding ISS


Pathways (from Reactome)
Pathway description
Formation of Senescence-Associated Heterochromatin Foci (SAHF)


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000018 small ears "outer ears of a smaller than normal size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Erbb2tm8.1(Erbb2)Mul/Erbb2tm8.1(Erbb2)Mul
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Hmga2pg/Hmga2pg
Genetic Background: involves: A/St * C57BL * MacArthurs small stock

 MP:0000435 shortened head "reduced anterior-posterior length of the head" [J:42035]
Show

Allelic Composition: Leprdb/Leprdb
Genetic Background: involves: C57BLKS/J

 MP:0000771 abnormal brain size "deviation from the average range of brain size for a given strain" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Hmga2pg-Tg40ACha/Hmga2pg-Tg40ACha
Genetic Background: involves: C57BL/6J * CBA/J

Allelic Composition: Hmga2pg-Tg40ACha/Hmga2+
Genetic Background: involves: C57BL/6J * CBA/J

 MP:0001127 small ovary "reduced size of the female reproductive gland containing the germ cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:35782]
Show

Allelic Composition: Hmga2pg/Hmga2pg
Genetic Background: involves: A/St * C57BL * MacArthurs small stock

 MP:0001147 small testis "reduced size of the male reproductive glands" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:58959]
Show

Allelic Composition: Hmga2pg/Hmga2pg
Genetic Background: involves: A/St * C57BL * MacArthurs small stock

Allelic Composition: Hmga2pg-Tg40ACha/Hmga2pg-Tg40ACha
Genetic Background: involves: C57BL/6J * CBA/J

Allelic Composition: Hmga2pg-Tg40ACha/Hmga2+
Genetic Background: involves: C57BL/6J * CBA/J

 MP:0001259 abnormal body weight "anomaly in average weight compared to the norm" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator]
Show

Allelic Composition: Hmga2tm1Cha/Hmga2tm1Cha,Lepob/Lepob
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Leprdb/Leprdb
Genetic Background: involves: C57BLKS/J

Allelic Composition: Hmga2pg/Hmga2pg
Genetic Background: involves: A/St * C57BL * MacArthurs small stock

Allelic Composition: Hmga2pg-Tg40ACha/Hmga2pg-Tg40ACha
Genetic Background: involves: C57BL/6J * CBA/J

Allelic Composition: Hmga2pg-Tg40ACha/Hmga2pg-Tg40BCha
Genetic Background: involves: C57BL/6J * CBA/J

Allelic Composition: Hmga2pg-Tg40BCha/Hmga2pg-Tg40BCha
Genetic Background: involves: C57BL/6J * CBA/J

Allelic Composition: Hmga2pg-Tg40ACha/Hmga2+
Genetic Background: involves: C57BL/6J * CBA/J

Allelic Composition: Hmga2tm1Cha/Hmga2+,Lepob/Lepob
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
Show

Allelic Composition: Erbb2tm8.1(Erbb2)Mul/Erbb2tm8.1(Erbb2)Mul
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Hmga2pg/Hmga2pg
Genetic Background: involves: A/St * C57BL * MacArthurs small stock

Allelic Composition: Hmga2pg-Tg40ACha/Hmga2pg-Tg40ACha
Genetic Background: involves: C57BL/6J * CBA/J

Allelic Composition: Hmga2pg-Tg40ACha/Hmga2pg-Tg40BCha
Genetic Background: involves: C57BL/6J * CBA/J

Allelic Composition: Hmga2pg-Tg40BCha/Hmga2pg-Tg40BCha
Genetic Background: involves: C57BL/6J * CBA/J

Allelic Composition: Hmga2tm1Cha/Hmga2+,Lepob/Lepob
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Hmga2tm1Cha/Hmga2tm1Cha,Lepob/Lepob
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Hmga2pg/Hmga2pg
Genetic Background: involves: A/St * C57BL * MacArthurs small stock

 MP:0001924 infertility "inability to produce live offspring" [J:47225]
Show

Allelic Composition: Erbb2tm8.1(Erbb2)Mul/Erbb2tm8.1(Erbb2)Mul
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001925 male infertility "inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
Show

Allelic Composition: Leprdb/Leprdb
Genetic Background: involves: C57BLKS/J

Allelic Composition: Hmga2pg/Hmga2pg
Genetic Background: involves: A/St * C57BL * MacArthurs small stock

 MP:0001926 female infertility "inability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:34193]
Show

Allelic Composition: Hmga2pg/Hmga2pg
Genetic Background: involves: A/St * C57BL * MacArthurs small stock

 MP:0001927 abnormal oestrous cycle (sensu Rodentia) "failure of or aberrant timing of the sexual cycle of female animals" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:34193]
Show

Allelic Composition: Hmga2pg/Hmga2pg
Genetic Background: involves: A/St * C57BL * MacArthurs small stock

 MP:0002089 abnormal postnatal growth/weight/body size "increased or decreased average body size, weight or growth characteristic abnormalities manifesting after birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Hmga2pg/Hmga2pg
Genetic Background: involves: A/St * C57BL * MacArthurs small stock

 MP:0002286 cryptorchism "failure of one or both of the testes to descend into the scrotum around the time of birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Hmga2pg/Hmga2pg
Genetic Background: involves: A/St * C57BL * MacArthurs small stock

 MP:0002566 abnormal sexual interaction "altered initiation, failure of initiation or incomplete mating behavior" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Erbb2tm8.1(Erbb2)Mul/Erbb2tm8.1(Erbb2)Mul
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0002637 small uterus "reduced size of the female muscular organ of gestation" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Hmga2pg/Hmga2pg
Genetic Background: involves: A/St * C57BL * MacArthurs small stock

 MP:0002758 long tail "increased length of tail relative to average of a given strain" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:82849]
Show

Allelic Composition: Hmga2pg/Hmga2pg
Genetic Background: involves: A/St * C57BL * MacArthurs small stock

 MP:0002768 small adrenal glands "reduced size of endocrine glands located above the kidneys responsible for hormone and epinephrine secretion" [J:78062]
Show

Allelic Composition: Hmga2pg-Tg40ACha/Hmga2pg-Tg40ACha
Genetic Background: involves: C57BL/6J * CBA/J

Allelic Composition: Hmga2pg-Tg40ACha/Hmga2+
Genetic Background: involves: C57BL/6J * CBA/J

 MP:0002772 brachypodia "abnormally short feet" [J:31930, il:Ira Lu , Mouse Genome Informatics Curator]
Show

Allelic Composition: Hmga2pg/Hmga2pg
Genetic Background: involves: A/St * C57BL * MacArthurs small stock

 MP:0002881 long hair "increased average length of the coat hairs" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Hmga2pg/Hmga2pg
Genetic Background: involves: A/St * C57BL * MacArthurs small stock

 MP:0003415 priapism "prolonged penile erection, often painful and without sexual desire " [smb:Susan M Bello, Mouse Genome Informatics Curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Hmga2pg/Hmga2pg
Genetic Background: involves: A/St * C57BL * MacArthurs small stock

 MP:0005159 azoospermia "absence of living spermatozoa " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Leprdb/Leprdb
Genetic Background: involves: C57BLKS/J

 MP:0005334 abnormal fat pad "malformed or aberrant size of the encapsulated adipose tissue" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Hmga2tm1Cha/Hmga2tm1Cha,Lepob/Lepob
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0005448 abnormal energy balance "aberrant intake or expenditure of calories as compared to the normal state" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Erbb2tm8.1(Erbb2)Mul/Erbb2tm8.1(Erbb2)Mul
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Hmga2pg/Hmga2pg
Genetic Background: involves: A/St * C57BL * MacArthurs small stock

 MP:0005459 decreased percent body fat "less fat, relative to the norm, as a percentage of total body weight" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Hmga2pg-Tg40BCha/Hmga2pg-Tg40BCha
Genetic Background: involves: C57BL/6J * CBA/J

Allelic Composition: Hmga2pg-Tg40BCha/Hmga2+
Genetic Background: involves: C57BL/6J * CBA/J

 MP:0005659 resistance to diet-induced obesity "less likely to become excessively fat or to increase fat in the subcutaneous connective tissue as a result of consuming a diet geared to increase body fat " [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator]
Show

Allelic Composition: Leprdb/Leprdb
Genetic Background: involves: C57BLKS/J

Allelic Composition: Hmga2tm1Cha/Hmga2+
Genetic Background: involves: 129S7/SvEvBrd

 MP:0006378 abnormal spermatogonia morphology "anomaly in the number, structure or development of the large unspecialized male germ cells that give rise to spermatocytes" [ISBN:0-8036-0655-99 "Taber s Cyclopedic Medical Dictionary, 19th edition", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Leprdb/Leprdb
Genetic Background: involves: C57BLKS/J

 MP:0008489 postnatal slow weight gain "the weight gain over a span of postnatal developmental time is slower than controls, with or without ever attaining a similar weight to controls as adults" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Erbb2tm8.1(Erbb2)Mul/Erbb2tm8.1(Erbb2)Mul
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Hmga2pg/Hmga2pg
Genetic Background: involves: A/St * C57BL * MacArthurs small stock

 MP:0008974 proportional dwarf "abnormally undersized with both limbs and trunk symmetrically shorter; usually due to chemical, endocrine, nutritional or nonosseous influences" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Erbb2tm8.1(Erbb2)Mul/Erbb2tm8.1(Erbb2)Mul
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Hmga2pg-Tg40ACha/Hmga2pg-Tg40ACha
Genetic Background: involves: C57BL/6J * CBA/J

Allelic Composition: Hmga2pg-Tg40ACha/Hmga2pg-Tg40BCha
Genetic Background: involves: C57BL/6J * CBA/J

Allelic Composition: Hmga2pg-Tg40BCha/Hmga2pg-Tg40BCha
Genetic Background: involves: C57BL/6J * CBA/J

 MP:0009293 decreased inguinal fat pad weight 
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Allelic Composition: Hmga2tm1Cha/Hmga2tm1Cha,Lepob/Lepob
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0009299 decreased mesenteric fat pad weight 
Show

Allelic Composition: Hmga2tm1Cha/Hmga2tm1Cha,Lepob/Lepob
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0009674 decreased birth weight "reduction in average weight at birth compared to controls" [RGD:cur "Rat Genome Database submission"]
Show

Allelic Composition: Leprdb/Leprdb
Genetic Background: involves: C57BLKS/J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000039473 Ubn1 / Q4G0F8 / ubinuclein 1 / Q9NPG3*  / complex / reaction
 ENSMUSG00000022702 Hira / Q61666 / Protein HIRA / P54198* / histone cell cycle regulator*  / complex / reaction
 ENSMUSG00000019857 Asf1a / Q9CQE6 / Histone chaperone ASF1A / Q9Y294* / anti-silencing function 1A histone chaperone*  / complex / reaction
 ENSMUSG00000046711 Hmga1 / P17095 / High mobility group protein HMG-I/HMG-Y / P17096* / high mobility group AT-hook 1*  / complex / reaction
 ENSMUSG00000096210 H1f0 / P10922 / Histone H1.0 Histone H1.0, N-terminally processed / P07305* / H1 histone family member 0*  / reaction






 

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