Manteia - Molecule gene

ENSMUSG00000022702

Mus musculus

Features

Gene ID:	ENSMUSG00000022702

Biological name :	Hira

Synonyms :	Hira / Protein HIRA / Q61666

Possible biological names infered from orthology :	histone cell cycle regulator / P54198

Species:	Mus musculus

Chr. number:	16
Strand:	1
Band:	A3
Gene start:	18877037
Gene end:	18970309

Corresponding Affymetrix probe sets:	10434252 (MoGene1.0st) 1436241_s_at (Mouse Genome 430 2.0 Array) 1450049_a_at (Mouse Genome 430 2.0 Array) 1450050_at (Mouse Genome 430 2.0 Array) 1459103_at (Mouse Genome 430 2.0 Array)

Cross references:	Ensembl peptide - ENSMUSP00000004222 Ensembl peptide - ENSMUSP00000112614 Ensembl peptide - ENSMUSP00000117944 NCBI entrez gene - 15260 See in Manteia. MGI - MGI:99430 RefSeq - XM_006521802 RefSeq - NM_010435 RefSeq - XM_006521799 RefSeq - XM_006521800 RefSeq - XM_006521801 RefSeq - XM_006521798 RefSeq Peptide - NP_034565 swissprot - Q61666 swissprot - D6RE52 Ensembl - ENSMUSG00000022702

See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
hira	ENSDARG00000013434	Danio rerio
HIRA	ENSGALG00000033598	Gallus gallus
HIRA	ENSG00000100084	Homo sapiens

Paralog prediction (from Ensembl)

Paralog name

ID

Similarity(%)

No match

Protein motifs (from Interpro)

Interpro ID	Name
IPR001680	WD40 repeat
IPR011494	TUP1-like enhancer of split
IPR015943	WD40/YVTN repeat-like-containing domain superfamily
IPR017986	WD40-repeat-containing domain
IPR019015	HIRA B motif
IPR019775	WD40 repeat, conserved site
IPR031120	WD repeat HIR1
IPR036322	WD40-repeat-containing domain superfamily

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0001649	osteoblast differentiation	IGI
biological_process	GO:0006325	chromatin organization	IEA
biological_process	GO:0006336	DNA replication-independent nucleosome assembly	IEA
biological_process	GO:0006351	transcription, DNA-templated	IEA
biological_process	GO:0006355	regulation of transcription, DNA-templated	IEA
biological_process	GO:0007369	gastrulation	IMP
biological_process	GO:0031935	regulation of chromatin silencing	IBA
biological_process	GO:0042692	muscle cell differentiation	IGI
biological_process	GO:1903507	negative regulation of nucleic acid-templated transcription	IEA
cellular_component	GO:0000790	nuclear chromatin	IEA
cellular_component	GO:0005634	nucleus	IEA
cellular_component	GO:0016605	PML body	IEA
cellular_component	GO:0032991	protein-containing complex	IEA
molecular_function	GO:0003714	transcription corepressor activity	IBA
molecular_function	GO:0005515	protein binding	IPI
molecular_function	GO:0031491	nucleosome binding	IBA

Pathways (from Reactome)

Pathway description

Formation of Senescence-Associated Heterochromatin Foci (SAHF)

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
MP:0000221	decreased WBC count	"fewer than normal numbers of WBCs" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Hdac8^{tm1a(EUCOMM)Wtsi}/Hdac8^{tm1a(EUCOMM)Wtsi} Genetic Background: C57BL/6N-Hdac8^{tm1a(EUCOMM)Wtsi}/Wtsi
MP:0000266	abnormal cardiac morphology	"anomalies in the hollow, muscular organ that maintains the circulation of the blood" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Hira^tm1Pjs/Hira^tm1Pjs Genetic Background: involves: 129S1/Sv * C57BL/6 Allelic Composition: Gt(ROSA)26Sor^{tm3(CAG-EYFP)Hze}/Gt(ROSA)26Sor⁺,Hira^{tm1c(EUCOMM)Wtsi}/Hira^{tm1d(EUCOMM)Wtsi},Tg(Myh6-cre)2182Mds/0 Genetic Background: B6.Cg-Gt(ROSA)26Sor^{tm3(CAG-EYFP)Hze} Hira^{tm1c(EUCOMM)Wtsi}/Hira^{tm1d(EUCOMM)Wtsi} Tg(Myh6-cre)2182Mds
MP:0000267	abnormal cardiac development	"aberrant formation or incomplete differentiation of the heart" [MGI:cls, J:53370]	Show Allelic Composition: Tsc2^tm1Mjg/Tsc2⁺ Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 Allelic Composition: Hira^tm1Pjs/Hira^tm1Pjs Genetic Background: involves: 129S1/Sv * C57BL/6
MP:0000270	abnormal heart tube morphology	"malformed embryonic heart " [J:37888]	Show Allelic Composition: Tsc2^tm1Mjg/Tsc2⁺ Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
MP:0000278	abnormal myocardial fiber morphology	"malformed or poorly developed cardiac muscle fibers, the multinucleated muscle cells of the heart" [J:18048]	Show Allelic Composition: Gt(ROSA)26Sor^{tm3(CAG-EYFP)Hze}/Gt(ROSA)26Sor⁺,Hira^{tm1c(EUCOMM)Wtsi}/Hira^{tm1d(EUCOMM)Wtsi},Tg(Myh6-cre)2182Mds/0 Genetic Background: B6.Cg-Gt(ROSA)26Sor^{tm3(CAG-EYFP)Hze} Hira^{tm1c(EUCOMM)Wtsi}/Hira^{tm1d(EUCOMM)Wtsi} Tg(Myh6-cre)2182Mds
MP:0000432	abnormal head morphology	"anomalous structure or development of the portion of the body containing the brain and organs of sight, hearing, taste, and smell " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Tsc2^tm1Mjg/Tsc2⁺ Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 Allelic Composition: Hira^tm1Pjs/Hira^tm1Pjs Genetic Background: involves: 129S1/Sv * C57BL/6
MP:0000783	abnormal forebrain morphology	"malformed or absent anterior primitive cerebral vesicle; most rostral of three primary vesicles of the embryonic neural tube" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:38857]	Show Allelic Composition: Tsc2^tm1Mjg/Tsc2⁺ Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
MP:0000913	abnormal brain development	"malformed or incomplete differentiation of the brain" [MGI:cls, J:49840]	Show Allelic Composition: Tsc2^tm1Mjg/Tsc2⁺ Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 Allelic Composition: Hira^tm1Pjs/Hira^tm1Pjs Genetic Background: involves: 129S1/Sv * C57BL/6
MP:0000929	open neural tube	"incomplete invagination and fusion of the neuroepithelial layer in early development" [MGI:CLS, J:53370, J:62571]	Show Allelic Composition: Hira^tm1Pjs/Hira^tm1Pjs Genetic Background: involves: 129S1/Sv * C57BL/6
MP:0001544	abnormal cardiovascular system physiology	"anomalous function of the blood, blood vessels, and/or the heart" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Mir301^tm1Yoli/Mir301^tm1Yoli Genetic Background: involves: C57BL/6J
MP:0001614	abnormal vasculature	"anomalies in the structure of development of the network of tubes that carries blood through the body" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Tsc2^tm1Mjg/Tsc2⁺ Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
MP:0001636	irregular heartbeat	"uneven timing of heart contraction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:33038]	Show Allelic Composition: Tsc2^tm1Mjg/Tsc2⁺ Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
MP:0001672	abnormal embryogenesis/ development	"anomaly in the establishment of the characteristic configuration of the embryonic body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Tsc2^tm1Mjg/Tsc2⁺ Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 Allelic Composition: Hira^tm2Pjs/Hira^tm2Pjs Genetic Background: involves: 129S6/SvEvTac * C57BL/6 Allelic Composition: Hira^{Tn(mm-DTT-3XSstop)L.1Ddra}/Hira^{Tn(mm-DTT-3XSstop)L.1Ddra} Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6 * FVB/N
MP:0001684	abnormal axial mesoderm	"malformed middle primary germ layer" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:51834]	Show Allelic Composition: Hira^tm1Pjs/Hira^tm1Pjs Genetic Background: involves: 129S1/Sv * C57BL/6
MP:0001689	incomplete somite formation	"arrest of differentiation or patterning of the somites" [J:62882]	Show Allelic Composition: Hira^tm1Pjs/Hira^tm1Pjs Genetic Background: involves: 129S1/Sv * C57BL/6
MP:0001691	abnormal somite shape	"atypical characteristic surface configuration of a segmental mass along the notochord of the developing embryo" [J:37888]	Show Allelic Composition: Tsc2^tm1Mjg/Tsc2⁺ Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 Allelic Composition: Hira^tm1Pjs/Hira^tm1Pjs Genetic Background: involves: 129S1/Sv * C57BL/6
MP:0001696	failure to gastrulate	"inability to differentiate and invaginate the primary germ layers" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:34458]	Show Allelic Composition: Tsc2^tm1Mjg/Tsc2⁺ Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 Allelic Composition: Hira^tm1Pjs/Hira^tm1Pjs Genetic Background: involves: 129S1/Sv * C57BL/6
MP:0001698	reduced embryo size	"smaller proportions of embryo compared to littermates" [J:61790]	Show Allelic Composition: Hira^tm1Pjs/Hira^tm1Pjs Genetic Background: involves: 129S1/Sv * C57BL/6
MP:0001700	abnormal embryo turning	"atypical axial rotation of the germ layers of the embryo during the primitive streak/early somite stage (Mus:E8.5-E9.5) such that the curvature of the entire trunk region is reversed and the neural ectoderm moves to the convex region and the midgut region becomes located in the concave region" [The Atlas of Mouse Development:ISBN 0-12-402035-6, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Tsc2^tm1Mjg/Tsc2⁺ Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 Allelic Composition: Hira^tm1Pjs/Hira^tm1Pjs Genetic Background: involves: 129S1/Sv * C57BL/6
MP:0001706	abnormal left-right axis patterning	"anomaly in the formation or development of the body or a specific organ of the body in relation to the left and right sides of the body or organ" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Hira^tm1Pjs/Hira^tm1Pjs Genetic Background: involves: 129S1/Sv * C57BL/6
MP:0001726	abnormal allantois	"malformed fetal membrane which contributes to the formation of the umbilical cord and placenta" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:12622]	Show Allelic Composition: Tsc2^tm1Mjg/Tsc2⁺ Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
MP:0001730	embryonic growth arrest	"the cessation of development beyond a particular stage" [J:17509]	Show Allelic Composition: Hira^tm1Pjs/Hira^tm1Pjs Genetic Background: involves: 129S1/Sv * C57BL/6
MP:0001787	pericardial edema	"accumulation of watery fluid in the pericardial sac of the heart" [J:52597]	Show Allelic Composition: Tsc2^tm1Mjg/Tsc2⁺ Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
MP:0002084	abnormal developmental patterning	"abnormal systematic arrangement of the developing body along an axis" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Hira^tm1Pjs/Hira^tm1Pjs Genetic Background: involves: 129S1/Sv * C57BL/6
MP:0002085	abnormal embryonic tissue morphology	"structural abnormality or development of any embryonic tissue resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Hira^tm1Pjs/Hira^tm1Pjs Genetic Background: involves: 129S1/Sv * C57BL/6
MP:0002128	abnormal blood circulation	"failure or atypical movement in the flow of blood from the heart to the vasculature and back to the heart" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Gt(ROSA)26Sor^{tm3(CAG-EYFP)Hze}/Gt(ROSA)26Sor⁺,Hira^{tm1c(EUCOMM)Wtsi}/Hira^{tm1d(EUCOMM)Wtsi},Tg(Myh6-cre)2182Mds/0 Genetic Background: B6.Cg-Gt(ROSA)26Sor^{tm3(CAG-EYFP)Hze} Hira^{tm1c(EUCOMM)Wtsi}/Hira^{tm1d(EUCOMM)Wtsi} Tg(Myh6-cre)2182Mds
MP:0002151	abnormal neural tube morphology/development	"anomalous structure of or development of the embryonic neural tube resulting in structural anomaly" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Hira^tm1Pjs/Hira^tm1Pjs Genetic Background: involves: 129S1/Sv * C57BL/6
MP:0002231	abnormal primitive streak morphology	"anomaly in the midline ridge of the embryonic epiblast that later develops into mesoderm and endoderm" [The Atlas of Mouse Development:ISBN 0-12-402035-6, csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]	Show Allelic Composition: Hira^tm1Pjs/Hira^tm1Pjs Genetic Background: involves: 129S1/Sv * C57BL/6
MP:0002825	abnormal notochord	"malformation or absence of the axial fibrocellular cord in embryos around which develops the vertebral primordia" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Hira^tm1Pjs/Hira^tm1Pjs Genetic Background: involves: 129S1/Sv * C57BL/6
MP:0002884	abnormal branchial arches	"malformation or anomaly in the transient structures of the embryo that develop into regions of the head, neck and ears" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Hira^tm1Pjs/Hira^tm1Pjs Genetic Background: involves: 129S1/Sv * C57BL/6
MP:0002972	abnormal cardiac muscle contractility	"altered ability of the heart muscle to shorten or to develop increased tension, often measured by dP/dT max" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Gt(ROSA)26Sor^{tm3(CAG-EYFP)Hze}/Gt(ROSA)26Sor⁺,Hira^{tm1c(EUCOMM)Wtsi}/Hira^{tm1d(EUCOMM)Wtsi},Tg(Myh6-cre)2182Mds/0 Genetic Background: B6.Cg-Gt(ROSA)26Sor^{tm3(CAG-EYFP)Hze} Hira^{tm1c(EUCOMM)Wtsi}/Hira^{tm1d(EUCOMM)Wtsi} Tg(Myh6-cre)2182Mds
MP:0003141	cardiac fibrosis	"formation of fibrous tissue within the heart often resulting from inflammation or injury " [smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Gt(ROSA)26Sor^{tm3(CAG-EYFP)Hze}/Gt(ROSA)26Sor⁺,Hira^{tm1c(EUCOMM)Wtsi}/Hira^{tm1d(EUCOMM)Wtsi},Tg(Myh6-cre)2182Mds/0 Genetic Background: B6.Cg-Gt(ROSA)26Sor^{tm3(CAG-EYFP)Hze} Hira^{tm1c(EUCOMM)Wtsi}/Hira^{tm1d(EUCOMM)Wtsi} Tg(Myh6-cre)2182Mds
MP:0003229	abnormal vitelline vasculature	"malformation in the vessels of the yolk sac" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:93257]	Show Allelic Composition: Tsc2^tm1Mjg/Tsc2⁺ Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
MP:0003345	decreased number of ribs	"fewer than normal numbers of the pairs of bony structures that make up the body wall" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, ncbi:Matthew Mailman, NCBI request]	Show Allelic Composition: Hdac8^{tm1a(EUCOMM)Wtsi}/Hdac8^{tm1a(EUCOMM)Wtsi} Genetic Background: C57BL/6N-Hdac8^{tm1a(EUCOMM)Wtsi}/Wtsi
MP:0003393	decreased cardiac output	"reduction in the blood volume pumped by each ventricle per minute" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Gt(ROSA)26Sor^{tm3(CAG-EYFP)Hze}/Gt(ROSA)26Sor⁺,Hira^{tm1c(EUCOMM)Wtsi}/Hira^{tm1d(EUCOMM)Wtsi},Tg(Myh6-cre)2182Mds/0 Genetic Background: B6.Cg-Gt(ROSA)26Sor^{tm3(CAG-EYFP)Hze} Hira^{tm1c(EUCOMM)Wtsi}/Hira^{tm1d(EUCOMM)Wtsi} Tg(Myh6-cre)2182Mds
MP:0003400	kinked neural tube	"twists or kinks in the embryonic neural tube" [J:66514, anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]	Show Allelic Composition: Hira^tm1Pjs/Hira^tm1Pjs Genetic Background: involves: 129S1/Sv * C57BL/6
MP:0003674	oxidative stress	"condition characterized by an accumulation of free radical groups in the body, which creates a potentially unstable and damaging cellular environment linked to tissue damage, accelerated aging, and degenerative disease; can result from many factors, including exposure to alcohol, medications, poor nutrition, trauma, cold or toxins; may be indicated by low antioxidant levels measured in blood plasma" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Gt(ROSA)26Sor^{tm3(CAG-EYFP)Hze}/Gt(ROSA)26Sor⁺,Hira^{tm1c(EUCOMM)Wtsi}/Hira^{tm1d(EUCOMM)Wtsi},Tg(Myh6-cre)2182Mds/0 Genetic Background: B6.Cg-Gt(ROSA)26Sor^{tm3(CAG-EYFP)Hze} Hira^{tm1c(EUCOMM)Wtsi}/Hira^{tm1d(EUCOMM)Wtsi} Tg(Myh6-cre)2182Mds
MP:0003984	embryonic growth retardation	"slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Tsc2^tm1Mjg/Tsc2⁺ Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 Allelic Composition: Hira^tm1Pjs/Hira^tm1Pjs Genetic Background: involves: 129S1/Sv * C57BL/6
MP:0004073	caudal body truncation	"caudal part of body truncated with anterior portion relatively normal" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Tsc2^tm1Mjg/Tsc2⁺ Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
MP:0004096	abnormal midbrain-hindbrain boundary development	"anomaly in the formation of the midbrain-hindbrain domain, comprised of the mesencephalic vesicle and the first rhombencephalic vesicle at early somitogenesis stages; an organizing center at the boundary patterns the midbrain and hindbrain primordia of the neural plate" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Hira^tm1Pjs/Hira^tm1Pjs Genetic Background: involves: 129S1/Sv * C57BL/6
MP:0004121	abnormal sarcolemma morphology	"structural anomaly in the plasma membrane of a muscle fiber that is cabable of conducting electrical impuses" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Gt(ROSA)26Sor^{tm3(CAG-EYFP)Hze}/Gt(ROSA)26Sor⁺,Hira^{tm1c(EUCOMM)Wtsi}/Hira^{tm1d(EUCOMM)Wtsi},Tg(Myh6-cre)2182Mds/0 Genetic Background: B6.Cg-Gt(ROSA)26Sor^{tm3(CAG-EYFP)Hze} Hira^{tm1c(EUCOMM)Wtsi}/Hira^{tm1d(EUCOMM)Wtsi} Tg(Myh6-cre)2182Mds
MP:0004215	abnormal myocardial fiber physiology	"anomaly in the function of the multinucleated muscle cells of the heart" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Gt(ROSA)26Sor^{tm3(CAG-EYFP)Hze}/Gt(ROSA)26Sor⁺,Hira^{tm1c(EUCOMM)Wtsi}/Hira^{tm1d(EUCOMM)Wtsi},Tg(Myh6-cre)2182Mds/0 Genetic Background: B6.Cg-Gt(ROSA)26Sor^{tm3(CAG-EYFP)Hze} Hira^{tm1c(EUCOMM)Wtsi}/Hira^{tm1d(EUCOMM)Wtsi} Tg(Myh6-cre)2182Mds
MP:0004251	failure of looping morphogenesis	"failure of the primitive heart tube to initiate or complete looping" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Tsc2^tm1Mjg/Tsc2⁺ Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
MP:0004261	abnormal embryonic neuroepithelium morphology	"any structural anomaly in the epithelial cell layer that lines the neural tube and develops into the nervous system and into the neural crest cells" [ISBN:0838580343 "Kandel ER, et al. Principles of Neural Science, 3rd edition", MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]	Show Allelic Composition: Hira^tm1Pjs/Hira^tm1Pjs Genetic Background: involves: 129S1/Sv * C57BL/6
MP:0004387	abnormal prechordal plate morphology	"any structural anomaly of the horseshoe-shaped thickening of the endoderm at the cranial (rostral) end of the primitive streak formed by the involution of Spemann s organizer cells which, together with the notochord, induces the formation of the neural plate from the overlying ectodermal cells and contributes mesodermal type cells to the surrounding tissue" [ISBN:0838580343 "Kandel ER, et al. Principles of Neural Science, 3rd edition"]	Show Allelic Composition: Hira^tm1Pjs/Hira^tm1Pjs Genetic Background: involves: 129S1/Sv * C57BL/6
MP:0004556	enlarged allantois	"increased size of the fetal membrane which contributes to the formation of the umbilical cord and placental blood vessels" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Hira^tm1Pjs/Hira^tm1Pjs Genetic Background: involves: 129S1/Sv * C57BL/6
MP:0004566	myocardial fiber degeneration	"deterioration or destruction of cardiac muscle fibers, the multinucleated muscle cells of the heart" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]	Show Allelic Composition: Gt(ROSA)26Sor^{tm3(CAG-EYFP)Hze}/Gt(ROSA)26Sor⁺,Hira^{tm1c(EUCOMM)Wtsi}/Hira^{tm1d(EUCOMM)Wtsi},Tg(Myh6-cre)2182Mds/0 Genetic Background: B6.Cg-Gt(ROSA)26Sor^{tm3(CAG-EYFP)Hze} Hira^{tm1c(EUCOMM)Wtsi}/Hira^{tm1d(EUCOMM)Wtsi} Tg(Myh6-cre)2182Mds
MP:0005221	abnormal rostral-caudal axis patterning	"anomaly in the development or formation of the axis that runs from the head to the tail of the body" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Tsc2^tm1Mjg/Tsc2⁺ Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
MP:0005657	abnormal neural plate morphology	"malformation or absence of the neuroectodermal area of the embryo s dorsal surface that develops into the neural tube and neural crest" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, hdene:Howard Dene , Mouse Genome Informatics Curator, J:68142]	Show Allelic Composition: Hira^tm1Pjs/Hira^tm1Pjs Genetic Background: involves: 129S1/Sv * C57BL/6
MP:0006108	abnormal hindbrain development	"anomaly in the formation or pattering of the caudal region of the brain" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:93573]	Show Allelic Composition: Hira^tm1Pjs/Hira^tm1Pjs Genetic Background: involves: 129S1/Sv * C57BL/6
MP:0006138	congestive heart failure	"the heart is unable to adequately pump blood throughout the body" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Gt(ROSA)26Sor^{tm3(CAG-EYFP)Hze}/Gt(ROSA)26Sor⁺,Hira^{tm1c(EUCOMM)Wtsi}/Hira^{tm1d(EUCOMM)Wtsi},Tg(Myh6-cre)2182Mds/0 Genetic Background: B6.Cg-Gt(ROSA)26Sor^{tm3(CAG-EYFP)Hze} Hira^{tm1c(EUCOMM)Wtsi}/Hira^{tm1d(EUCOMM)Wtsi} Tg(Myh6-cre)2182Mds
MP:0008029	abnormal paraxial mesoderm	"failure or abnormality in the formation of the mesoderm lying at either side of the midline embryonic notochord; on segmentation, paraxial mesoderm forms the paired somites" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Tsc2^tm1Mjg/Tsc2⁺ Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
MP:0009266	abnormal mesendoderm development	"failure or abnormality in the formation of the embryonic cell layer that gives rise to both the endoderm and mesoderm" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Hira^tm1Pjs/Hira^tm1Pjs Genetic Background: involves: 129S1/Sv * C57BL/6
MP:0009657	failure of chorioallantoic fusion	"failure to initiate and/or complete the formation of a highly vascularized extra-embryonic fetal membrane by fusion of the chorion and allantois" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Hira^tm1Pjs/Hira^tm1Pjs Genetic Background: involves: 129S1/Sv * C57BL/6
MP:0011098	complete embryonic lethality during organogenesis	"death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]	Show Allelic Composition: Tsc2^tm1Mjg/Tsc2⁺ Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 Allelic Composition: Hira^tm1Pjs/Hira^tm1Pjs Genetic Background: involves: 129S1/Sv * C57BL/6 Allelic Composition: Hira^tm2Pjs/Hira^tm2Pjs Genetic Background: involves: 129S6/SvEvTac * C57BL/6 Allelic Composition: Hira^{Tn(mm-DTT-3XSstop)L.1Ddra}/Hira^{Tn(mm-DTT-3XSstop)L.1Ddra} Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6 * FVB/N
MP:0011260	abnormal head mesenchyme morphology	"any structural anomaly of the primordial embryonic connective tissue of the developing head, consisting of mesenchymal cells supported in interlaminar jelly, that derive mostly from the mesoderm and contribute to head connective tissue, bone and musculature in conjunction with cranial neural crest cells" [ISBN:0-683-40008-8]	Show Allelic Composition: Hira^tm1Pjs/Hira^tm1Pjs Genetic Background: involves: 129S1/Sv * C57BL/6
MP:0011732	decreased somite size	"reduced size of any of the segmental masses along the notochord of the developing embryo" [MGI:smb]	Show Allelic Composition: Tsc2^tm1Mjg/Tsc2⁺ Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 Allelic Composition: Hira^tm1Pjs/Hira^tm1Pjs Genetic Background: involves: 129S1/Sv * C57BL/6
MP:0011952	decreased cardiac stroke volume	"reduction in the volume of blood pushed into the aorta with each beat of the heart" [MGI:csmith]	Show Allelic Composition: Gt(ROSA)26Sor^{tm3(CAG-EYFP)Hze}/Gt(ROSA)26Sor⁺,Hira^{tm1c(EUCOMM)Wtsi}/Hira^{tm1d(EUCOMM)Wtsi},Tg(Myh6-cre)2182Mds/0 Genetic Background: B6.Cg-Gt(ROSA)26Sor^{tm3(CAG-EYFP)Hze} Hira^{tm1c(EUCOMM)Wtsi}/Hira^{tm1d(EUCOMM)Wtsi} Tg(Myh6-cre)2182Mds
MP:0012135	embryonic-extraembryonic boundary constriction	"an invagination or pinching in the visceral endoderm that is centered at the boundary between embryonic and extra-embryonic regions of the developing embryo, often resulting in physical separation of embryonic and extraembryonic ectoderm" [MGI:csmith]	Show Allelic Composition: Hira^tm1Pjs/Hira^tm1Pjs Genetic Background: involves: 129S1/Sv * C57BL/6

Interacting proteins (from Reactome)

Interactor ID	Name	Interaction type
ENSMUSG00000019857	Asf1a / Q9CQE6 / Histone chaperone ASF1A / Q9Y294* / anti-silencing function 1A histone chaperone*	/ complex / reaction
ENSMUSG00000039473	Ubn1 / Q4G0F8 / ubinuclein 1 / Q9NPG3*	/ complex / reaction
ENSMUSG00000056758	Hmga2 / P52927 / high mobility group AT-hook 2 / P52926*	/ complex / reaction
ENSMUSG00000046711	Hmga1 / P17095 / High mobility group protein HMG-I/HMG-Y / P17096* / high mobility group AT-hook 1*	/ complex / reaction
ENSMUSG00000096210	H1f0 / P10922 / Histone H1.0 Histone H1.0, N-terminally processed / P07305* / H1 histone family member 0*	/ reaction

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