ENSMUSG00000019857


Mus musculus

Features
Gene ID: ENSMUSG00000019857
  
Biological name :Asf1a
  
Synonyms : Asf1a / Histone chaperone ASF1A / Q9CQE6
  
Possible biological names infered from orthology : anti-silencing function 1A histone chaperone / Q9Y294
  
Species: Mus musculus
  
Chr. number: 10
Strand: 1
Band: B3
Gene start: 53596757
Gene end: 53609225
  
Corresponding Affymetrix probe sets: 10363163 (MoGene1.0st)   1423511_at (Mouse Genome 430 2.0 Array)   1459882_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000151324
Ensembl peptide - ENSMUSP00000151729
Ensembl peptide - ENSMUSP00000151630
Ensembl peptide - ENSMUSP00000020004
NCBI entrez gene - 66403     See in Manteia.
MGI - MGI:1913653
RefSeq - NM_025541
RefSeq Peptide - NP_079817
swissprot - A0A1W2P7K2
swissprot - A0A1W2P7E1
swissprot - Q9CQE6
Ensembl - ENSMUSG00000019857
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ASF1AENSGALG00000014887Gallus gallus
 ASF1AENSG00000111875Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Asf1b / Q9DAP7 / Histone chaperone ASF1B / Q9NVP2* / anti-silencing function 1B histone chaperone*ENSMUSG0000000547071


Protein motifs (from Interpro)
Interpro ID Name
 IPR006818  Histone chaperone ASF1-like
 IPR036747  Histone chaperone ASF1-like superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001649 osteoblast differentiation IGI
 biological_processGO:0006281 DNA repair IEA
 biological_processGO:0006325 chromatin organization IEA
 biological_processGO:0006333 chromatin assembly or disassembly IEA
 biological_processGO:0006334 nucleosome assembly IEA
 biological_processGO:0006335 DNA replication-dependent nucleosome assembly IEA
 biological_processGO:0006336 DNA replication-independent nucleosome assembly IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0042692 muscle cell differentiation IGI
 cellular_componentGO:0000790 nuclear chromatin IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0032991 protein-containing complex IEA
 molecular_functionGO:0003682 chromatin binding IDA
 molecular_functionGO:0042393 histone binding IEA


Pathways (from Reactome)
Pathway description
Formation of Senescence-Associated Heterochromatin Foci (SAHF)


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001697 abnormal embryo size "anomalous proportions of embryo compared to littermates" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator]
Show

Allelic Composition: Mbpshi-mld/Mbpshi-mld
Genetic Background: MDB/Dt

Allelic Composition: Asf1atm1b(KOMP)Wtsi/Asf1a+
Genetic Background: C57BL/6N-Asf1atm1b(KOMP)Wtsi/J

 MP:0001700 abnormal embryo turning "atypical axial rotation of the germ layers of the embryo during the primitive streak/early somite stage (Mus:E8.5-E9.5) such that the curvature of the entire trunk region is reversed and the neural ectoderm moves to the convex region and the midgut region becomes located in the concave region" [The Atlas of Mouse Development:ISBN 0-12-402035-6, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Asf1atm1b(KOMP)Wtsi/Asf1a+
Genetic Background: C57BL/6N-Asf1atm1b(KOMP)Wtsi/J

 MP:0002151 abnormal neural tube morphology/development "anomalous structure of or development of the embryonic neural tube resulting in structural anomaly" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Mbpshi-mld/Mbpshi-mld
Genetic Background: MDB/Dt

Allelic Composition: Asf1atm1b(KOMP)Wtsi/Asf1a+
Genetic Background: C57BL/6N-Asf1atm1b(KOMP)Wtsi/J

 MP:0003720 abnormal neural tube closure "abnormal invagination and fusion of the neuroepithelial layer in early development" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator, J:99099]
Show

Allelic Composition: Mbpshi-mld/Mbpshi-mld
Genetic Background: MDB/Dt

Allelic Composition: Asf1atm1b(KOMP)Wtsi/Asf1a+
Genetic Background: C57BL/6N-Asf1atm1b(KOMP)Wtsi/J

 MP:0003984 embryonic growth retardation "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Mbpshi-mld/Mbpshi-mld
Genetic Background: MDB/Dt

Allelic Composition: Asf1atm1b(KOMP)Wtsi/Asf1a+
Genetic Background: C57BL/6N-Asf1atm1b(KOMP)Wtsi/J

 MP:0011092 complete embryonic lethality "death of all organisms of a given genotype in a population within the embryonic period prior to organogenesis (Mus: prior to E14)" [MGI:csmith]
Show

Allelic Composition: Lrrk2tm2.1Npa/Lrrk2tm2.1Npa
Genetic Background: involves: BALB/c * C57BL/6J

 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Mbpshi-mld/Mbpshi-mld
Genetic Background: MDB/Dt

 MP:0013292 embryonic lethality prior to organogenesis "death prior to the completion of embryo turning (Mus: E9-9.5)" [MGI:smb]
Show

Allelic Composition: Mbpshi-mld/Mbpshi-mld
Genetic Background: MDB/Dt

 MP:0013293 embryonic lethality prior to tooth bud stage "death prior to the appearance of tooth buds (Mus: E12-E12.5)" [MGI:smb]
Show

Allelic Composition: Mbpshi-mld/Mbpshi-mld
Genetic Background: MDB/Dt

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000022702 Hira / Q61666 / Protein HIRA / P54198* / histone cell cycle regulator*  / reaction / complex
 ENSMUSG00000039473 Ubn1 / Q4G0F8 / ubinuclein 1 / Q9NPG3*  / complex / reaction
 ENSMUSG00000056758 Hmga2 / P52927 / high mobility group AT-hook 2 / P52926*  / complex / reaction
 ENSMUSG00000046711 Hmga1 / P17095 / High mobility group protein HMG-I/HMG-Y / P17096* / high mobility group AT-hook 1*  / reaction / complex
 ENSMUSG00000096210 H1f0 / P10922 / Histone H1.0 Histone H1.0, N-terminally processed / P07305* / H1 histone family member 0*  / reaction






 

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