ENSG00000169598


Homo sapiens

Features
Gene ID: ENSG00000169598
  
Biological name :DFFB
  
Synonyms : DFFB / DNA fragmentation factor subunit beta / O76075
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 1
Strand: 1
Band: p36.32
Gene start: 3857267
Gene end: 3885429
  
Corresponding Affymetrix probe sets: 206752_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000463688
Ensembl peptide - ENSP00000462770
Ensembl peptide - ENSP00000463704
Ensembl peptide - ENSP00000486916
Ensembl peptide - ENSP00000339524
Ensembl peptide - ENSP00000343218
Ensembl peptide - ENSP00000345906
Ensembl peptide - ENSP00000367448
Ensembl peptide - ENSP00000367454
Ensembl peptide - ENSP00000436775
Ensembl peptide - ENSP00000462175
NCBI entrez gene - 1677     See in Manteia.
OMIM - 601883
RefSeq - XM_017000500
RefSeq - NM_001282669
RefSeq - NM_001320132
RefSeq - NM_001320136
RefSeq - NM_004402
RefSeq - XM_017000498
RefSeq - XM_017000499
RefSeq Peptide - NP_001307065
RefSeq Peptide - NP_004393
RefSeq Peptide - NP_001269598
RefSeq Peptide - NP_001307061
swissprot - O76075
swissprot - Q96P72
swissprot - A0A0B4J1S5
swissprot - Q96P73
swissprot - B4DZS0
swissprot - G3XAD0
swissprot - J3KT26
Ensembl - ENSG00000169598
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 dffbENSDARG00000009748Danio rerio
 DFFBENSGALG00000036295Gallus gallus
 DffbENSMUSG00000029027Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR003508  CIDE-N domain
 IPR015311  Apoptosis, DNA fragmentation factor 40kDa


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006308 DNA catabolic process IMP
 biological_processGO:0006309 apoptotic DNA fragmentation IEA
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0030263 apoptotic chromosome condensation IDA
 biological_processGO:0051260 protein homooligomerization IMP
 cellular_componentGO:0000790 nuclear chromatin IDA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005730 nucleolus IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol TAS
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0004518 nuclease activity IEA
 molecular_functionGO:0004536 deoxyribonuclease activity TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0019899 enzyme binding IPI
 molecular_functionGO:0019904 protein domain specific binding IPI
 molecular_functionGO:0042802 identical protein binding IMP
 molecular_functionGO:0097718 disordered domain specific binding IPI


Pathways (from Reactome)
Pathway description
Activation of DNA fragmentation factor


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000108424 KPNB1 / Q14974 / karyopherin subunit beta 1  / reaction / complex
 ENSG00000164305 CASP3 / P42574 / caspase 3  / reaction
 ENSG00000114030 KPNA1 / P52294 / karyopherin subunit alpha 1  / complex / reaction
 ENSG00000160049 DFFA / O00273 / DNA fragmentation factor subunit alpha  / reaction / complex
 ENSG00000169598 DFFB / O76075 / DNA fragmentation factor subunit beta  / - / complex / reaction
 ENSG00000189060 H1F0 / P07305 / H1 histone family member 0  / reaction / complex






 

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