ENSMUSG00000020538


Mus musculus

Features
Gene ID: ENSMUSG00000020538
  
Biological name :Srebf1
  
Synonyms : Mus musculus sterol regulatory element binding transcription factor 1 (Srebf1), transcript variant 4, mRNA. / Q9WTN3 / Srebf1
  
Possible biological names infered from orthology : P36956 / sterol regulatory element binding transcription factor 1
  
Species: Mus musculus
  
Chr. number: 11
Strand: -1
Band: B2
Gene start: 60199089
Gene end: 60222581
  
Corresponding Affymetrix probe sets: 10386473 (MoGene1.0st)   1426690_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000020846
Ensembl peptide - ENSMUSP00000120777
Ensembl peptide - ENSMUSP00000122934
NCBI entrez gene - 20787     See in Manteia.
MGI - MGI:107606
RefSeq - XM_011248845
RefSeq - NM_001358314
RefSeq - NM_001358315
RefSeq - NM_011480
RefSeq - XM_006532714
RefSeq - XM_006532715
RefSeq - XM_006532716
RefSeq - XM_006532717
RefSeq - NM_001313979
RefSeq Peptide - NP_035610
RefSeq Peptide - NP_001300908
RefSeq Peptide - NP_001345243
RefSeq Peptide - NP_001345244
swissprot - Q9WTN3
swissprot - F6XZS9
swissprot - A0A0A0MQK3
Ensembl - ENSMUSG00000020538
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 srebf1ENSDARG00000067607Danio rerio
 SREBF1ENSGALG00000027188Gallus gallus
 P36956ENSG00000072310Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q3U1N2 / Srebf2 / sterol regulatory element binding factor 2 / Q12772* / sterol regulatory element binding transcription factor 2*ENSMUSG0000002246342


Protein motifs (from Interpro)
Interpro ID Name
 IPR011598  Myc-type, basic helix-loop-helix (bHLH) domain
 IPR036638  Helix-loop-helix DNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IGI
 biological_processGO:0003062 regulation of heart rate by chemical signal IMP
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006629 lipid metabolic process IEA
 biological_processGO:0007568 aging IEA
 biological_processGO:0007623 circadian rhythm TAS
 biological_processGO:0008202 steroid metabolic process IEA
 biological_processGO:0008203 cholesterol metabolic process IEA
 biological_processGO:0008286 insulin receptor signaling pathway IDA
 biological_processGO:0008610 lipid biosynthetic process IDA
 biological_processGO:0009267 cellular response to starvation IEA
 biological_processGO:0009749 response to glucose IMP
 biological_processGO:0010867 positive regulation of triglyceride biosynthetic process IMP
 biological_processGO:0014070 response to organic cyclic compound IEA
 biological_processGO:0019217 regulation of fatty acid metabolic process IMP
 biological_processGO:0030324 lung development IEA
 biological_processGO:0030522 intracellular receptor signaling pathway IEA
 biological_processGO:0031065 positive regulation of histone deacetylation IDA
 biological_processGO:0031647 regulation of protein stability IEA
 biological_processGO:0032094 response to food IEA
 biological_processGO:0032526 response to retinoic acid IEA
 biological_processGO:0032570 response to progesterone IEA
 biological_processGO:0032869 cellular response to insulin stimulus IEA
 biological_processGO:0033762 response to glucagon IEA
 biological_processGO:0033993 response to lipid IEA
 biological_processGO:0042493 response to drug IEA
 biological_processGO:0042789 mRNA transcription by RNA polymerase II IDA
 biological_processGO:0043434 response to peptide hormone IEA
 biological_processGO:0045444 fat cell differentiation IMP
 biological_processGO:0045542 positive regulation of cholesterol biosynthetic process IMP
 biological_processGO:0045723 positive regulation of fatty acid biosynthetic process TAS
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0046676 negative regulation of insulin secretion IMP
 biological_processGO:0050796 regulation of insulin secretion IMP
 biological_processGO:0051591 response to cAMP IEA
 biological_processGO:0070542 response to fatty acid IEA
 biological_processGO:0071398 cellular response to fatty acid IEA
 biological_processGO:1903146 regulation of autophagy of mitochondrion IEA
 biological_processGO:1903214 regulation of protein targeting to mitochondrion IEA
 cellular_componentGO:0000139 Golgi membrane TAS
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005737 cytoplasm IDA
 cellular_componentGO:0005783 endoplasmic reticulum ISO
 cellular_componentGO:0005789 endoplasmic reticulum membrane IEA
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0012507 ER to Golgi transport vesicle membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0031410 cytoplasmic vesicle IEA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IEA
 molecular_functionGO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IEA
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IEA
 molecular_functionGO:0000982 transcription factor activity, RNA polymerase II proximal promoter sequence-specific DNA binding IDA
 molecular_functionGO:0001077 transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003682 chromatin binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0004879 nuclear receptor activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0019901 protein kinase binding IPI
 molecular_functionGO:0032810 sterol response element binding ISS
 molecular_functionGO:0043565 sequence-specific DNA binding IEA
 molecular_functionGO:0044212 transcription regulatory region DNA binding IDA
 molecular_functionGO:0046983 protein dimerization activity IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000187 abnormal triglyceride level "anomalous concentration of this molecule, glycerol esterified at each of its three hydroxyl groups by a fatty acid; triglyceride is an important molecule for storage of fatty acids in adipose tissue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Isl1tm1Tmj/Isl1tm1Tmj
Genetic Background: involves: 129S1/Sv

 MP:0002575 increased circulating ketone body level "greater than the normal amount of acetoacetate, 3-hydroxybutyrate and acteone in the blood; produced by fatty acid and carbohydrate metabolism and seen in conditions such as starvation and diabetes mellitus" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator, J:71968]
Show

Allelic Composition: Xrcc1tm1Pmc/Xrcc1tm1Pmc,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * SJL

 MP:0002644 decreased circulating triglyceride level "lower than normal concentration of triacylglycerols in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Isl1tm1Tmj/Isl1tm1Tmj
Genetic Background: involves: 129S1/Sv

Allelic Composition: Srebf1tm1Mbr/Srebf1tm1Mbr
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

Allelic Composition: Srebf1tm2Jdh/Srebf1tm2Jdh
Genetic Background: involves: 129S/SvEvBrd * C57BL/6

 MP:0005179 decreased total circulating cholesterol level "less than the normal concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Isl1tm1Tmj/Isl1tm1Tmj
Genetic Background: involves: 129S1/Sv

Allelic Composition: Srebf1tm1Mbr/Srebf1tm1Mbr
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

Allelic Composition: Srebf1tm2Jdh/Srebf1tm2Jdh
Genetic Background: involves: 129S/SvEvBrd * C57BL/6

 MP:0008770 decreased survivor rate "a smaller percentage of organisms than expected survive to adulthood and have a lifespan similar to controls" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Mecp2tm1Pplt/Mecp2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0009356 decreased liver triglyceride level "lower than normal concentration of triacylglycerols in the liver" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Xrcc1tm1Pmc/Xrcc1tm1Pmc,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129S1/Sv * C57BL/6 * SJL

 MP:0010027 increased liver cholesterol level "greater than normal amount in the liver of the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones; it is a component of the plasma membrane lipid bilayer and of plasma lipoproteins and can be found in all animal tissues" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Isl1tm1Tmj/Isl1tm1Tmj
Genetic Background: involves: 129S1/Sv

Allelic Composition: Srebf1tm1Jdh/Srebf1tm1Jdh
Genetic Background: involves: 129S/SvEvBrd * C57BL/6

Allelic Composition: Srebf1tm2Jdh/Srebf1tm2Jdh
Genetic Background: involves: 129S/SvEvBrd * C57BL/6

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Srebf1tm2Jdh/Srebf1tm2Jdh
Genetic Background: involves: 129S/SvEvBrd * C57BL/6

 MP:0011108 partial embryonic lethality during organogenesis "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
Show

Allelic Composition: Srebf1tm1Jdh/Srebf1tm1Jdh
Genetic Background: involves: 129S/SvEvBrd * C57BL/6

 MP:0011109 partial lethality throughout fetal growth and development "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Srebf1tm1Jdh/Srebf1tm1Jdh
Genetic Background: involves: 129S/SvEvBrd * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000001440 Kpnb1 / P70168 / Importin subunit beta-1 / Q14974* / karyopherin subunit beta 1*  / reaction / complex
 ENSMUSG00000022463 Q3U1N2 / Srebf2 / sterol regulatory element binding factor 2 / Q12772* / sterol regulatory element binding transcription factor 2*  / complex / reaction
 ENSMUSG00000020538 Q9WTN3 / Srebf1 / Mus musculus sterol regulatory element binding transcription factor 1 (Srebf1), transcript variant 4, mRNA. / P36956* / sterol regulatory element binding transcription factor 1*  / complex / reaction
 ENSMUSG00000032897 Nfyc / P70353 / Mus musculus nuclear transcription factor-Y gamma (Nfyc), transcript variant 4, mRNA. / Q13952* / nuclear transcription factor Y subunit gamma*  / complex / reaction
 ENSMUSG00000028287 1700009N14Rik / RIKEN cDNA 1700009N14 gene / RAN* / P62826* / RAN, member RAS oncogene family*  / reaction
 ENSMUSG00000091736 Yy2 / Q3TTC2 / Yy2 transcription factor / O15391*  / reaction
 ENSMUSG00000046873 Q3TTC2 / Mbtps2 / Q8CHX6 / Membrane-bound transcription factor site-2 protease / O43462* / membrane bound transcription factor peptidase, site 2*  / reaction
 ENSMUSG00000023994 Nfya / P23708 / Mus musculus nuclear transcription factor-Y alpha (Nfya), transcript variant 3, mRNA. / P23511* / nuclear transcription factor Y subunit alpha*  / reaction / complex
 ENSMUSG00000031835 Mbtps1 / Q9WTZ2 / Membrane-bound transcription factor site-1 protease / Q14703* / membrane bound transcription factor peptidase, site 1*  / reaction
 ENSMUSG00000032485 Scap / Q6GQT6 / SREBF chaperone / Q12770*  / complex
 ENSMUSG00000020248 Nfyb / P63139 / Nuclear transcription factor Y subunit beta / P25208*  / reaction / complex






 

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