ENSMUSG00000046873


Mus musculus

Features
Gene ID: ENSMUSG00000046873
  
Biological name :Mbtps2
  
Synonyms : Mbtps2 / Membrane-bound transcription factor site-2 protease / Q3TTC2 / Q8CHX6
  
Possible biological names infered from orthology : membrane bound transcription factor peptidase, site 2 / O43462
  
Species: Mus musculus
  
Chr. number: X
Strand: -1
Band: F4
Gene start: 157535371
Gene end: 157598715
  
Corresponding Affymetrix probe sets: 10607539 (MoGene1.0st)   1436883_at (Mouse Genome 430 2.0 Array)   1437495_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000108141
Ensembl peptide - ENSMUSP00000137233
Ensembl peptide - ENSMUSP00000118134
Ensembl peptide - ENSMUSP00000059471
NCBI entrez gene - 270669     See in Manteia.
MGI - MGI:2444506
RefSeq - NM_172307
RefSeq Peptide - NP_758511
swissprot - A0A0A0MQE2
swissprot - A2AC84
swissprot - Q3TTC2
swissprot - Q8CHX6
Ensembl - ENSMUSG00000046873
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 mbtps2ENSDARG00000057577Danio rerio
 MBTPS2ENSGALG00000016382Gallus gallus
 MBTPS2ENSG00000012174Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR001193  Membrane-bound transcription factor site-2 protease
 IPR008915  Peptidase M50
 IPR013083  Zinc finger, RING/FYVE/PHD-type
 IPR013087  Zinc finger C2H2-type
 IPR017114  C2H2-type Zinc finger protein, YY-1-like
 IPR036034  PDZ superfamily
 IPR036236  Zinc finger C2H2 superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006357 regulation of transcription by RNA polymerase II ISO
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0006629 lipid metabolic process IEA
 biological_processGO:0008202 steroid metabolic process IEA
 biological_processGO:0008203 cholesterol metabolic process IEA
 biological_processGO:0031293 membrane protein intracellular domain proteolysis IEA
 biological_processGO:0036500 ATF6-mediated unfolded protein response IBA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II ISO
 biological_processGO:0051091 positive regulation of DNA-binding transcription factor activity IEA
 biological_processGO:1990440 positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress IEA
 cellular_componentGO:0000139 Golgi membrane TAS
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005737 cytoplasm ISS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0000987 proximal promoter sequence-specific DNA binding IDA
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0004222 metalloendopeptidase activity IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0008237 metallopeptidase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0043565 sequence-specific DNA binding ISO
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Regulation of cholesterol biosynthesis by SREBP (SREBF)
ATF6 (ATF6-alpha) activates chaperones
CREB3 factors activate genes


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000026663 Atf6 / F6VAN0 / Cyclic AMP-dependent transcription factor ATF-6 alpha Processed cyclic AMP-dependent transcription factor ATF-6 alpha / P18850* / activating transcription factor 6*  / reaction
 ENSMUSG00000027938 Q9D2A5 / Creb3l4 / Cyclic AMP-responsive element-binding protein 3-like protein 4 Processed cyclic AMP-responsive element-binding protein 3-like protein 4 / Q8TEY5* / cAMP responsive elemen...  / reaction
 ENSMUSG00000035041 Q91XE9 / Creb3l3 / Cyclic AMP-responsive element-binding protein 3-like protein 3 Processed cyclic AMP-responsive element-binding protein 3-like protein 3 / Q68CJ9* / cAMP responsive elemen...  / reaction
 ENSMUSG00000038648 Q8BH52 / Creb3l2 / Cyclic AMP-responsive element-binding protein 3-like protein 2 Processed cyclic AMP-responsive element-binding protein 3-like protein 2 / Q70SY1* / cAMP responsive elemen...  / reaction
 ENSMUSG00000022463 Q3U1N2 / Srebf2 / sterol regulatory element binding factor 2 / Q12772* / sterol regulatory element binding transcription factor 2*  / reaction
 ENSMUSG00000020538 Q9WTN3 / Srebf1 / Mus musculus sterol regulatory element binding transcription factor 1 (Srebf1), transcript variant 4, mRNA. / P36956* / sterol regulatory element binding transcription factor 1*  / reaction






 

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