ENSMUSG00000027938


Mus musculus

Features
Gene ID: ENSMUSG00000027938
  
Biological name :Creb3l4
  
Synonyms : Creb3l4 / Cyclic AMP-responsive element-binding protein 3-like protein 4 Processed cyclic AMP-responsive element-binding protein 3-like protein 4 / Q9D2A5
  
Possible biological names infered from orthology : cAMP responsive element binding protein 3 like 4 / Q8TEY5
  
Species: Mus musculus
  
Chr. number: 3
Strand: -1
Band: F1
Gene start: 90237500
Gene end: 90243512
  
Corresponding Affymetrix probe sets: 10499751 (MoGene1.0st)   1424218_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000029547
Ensembl peptide - ENSMUSP00000102992
NCBI entrez gene - 78284     See in Manteia.
MGI - MGI:1916603
RefSeq - XM_017319808
RefSeq - NM_001307934
RefSeq - NM_001307935
RefSeq - NM_030080
RefSeq - XM_006502310
RefSeq - XM_006502311
RefSeq - XM_006502314
RefSeq - XM_006502315
RefSeq Peptide - NP_001294864
RefSeq Peptide - NP_084356
RefSeq Peptide - NP_001294863
swissprot - Q9D2A5
Ensembl - ENSMUSG00000027938
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 Q8TEY5ENSG00000143578Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q91XE9 / Creb3l3 / Cyclic AMP-responsive element-binding protein 3-like protein 3 Processed cyclic AMP-responsive element-binding protein 3-like protein 3 / Q68CJ9* / cAMP responsive elemen...ENSMUSG0000003504137
Q8BH52 / Creb3l2 / Cyclic AMP-responsive element-binding protein 3-like protein 2 Processed cyclic AMP-responsive element-binding protein 3-like protein 2 / Q70SY1* / cAMP responsive elemen...ENSMUSG0000003864825
Creb3 / cAMP responsive element binding protein 3 / O43889*ENSMUSG0000002846625
Creb3l1 / cAMP responsive element binding protein 3 like 1 / Q96BA8*ENSMUSG0000002723023


Protein motifs (from Interpro)
Interpro ID Name
 IPR004827  Basic-leucine zipper domain
 IPR008917  Transcription factor, Skn-1-like, DNA-binding domain superfamily
 IPR029807  cAMP-responsive element-binding protein 3-like protein 4


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0006986 response to unfolded protein IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007283 spermatogenesis IEA
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0030968 endoplasmic reticulum unfolded protein response IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IMP
 cellular_componentGO:0000139 Golgi membrane TAS
 cellular_componentGO:0002079 inner acrosomal membrane IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005739 mitochondrion ISO
 cellular_componentGO:0005783 endoplasmic reticulum ISO
 cellular_componentGO:0005789 endoplasmic reticulum membrane IEA
 cellular_componentGO:0005794 Golgi apparatus ISO
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0031410 cytoplasmic vesicle IEA
 cellular_componentGO:0031965 nuclear membrane ISO
 molecular_functionGO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IDA
 molecular_functionGO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding IMP
 molecular_functionGO:0003677 DNA binding IDA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0035497 cAMP response element binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002216 abnormal seminiferous tubule morphology "malformation of the tubules in the testes where spermatogenesis occurs" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Pafah1b1tm1Awb/Pafah1b1+
Genetic Background: involves: 129S6/SvEvTac

 MP:0002687 oligozoospermia "reduced concentration of spermatozoa " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:57312]
Show

Allelic Composition: Pafah1b1tm1Awb/Pafah1b1+
Genetic Background: involves: 129S6/SvEvTac

 MP:0004901 decreased male germ cell number "reduced numbers of male germ cells whether they are undifferentiated or fully differentiated" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Apoa2a/Apoa2a
Genetic Background: SAMP3

 MP:0006380 abnormal spermatid morphology "anomaly in the number or structure of the male germ cells that without further cell division give rise to mature spermatozoa" [ISBN:0-8036-0655-99 "Taber s Cyclopedic Medical Dictionary, 19th edition", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Apoa2a/Apoa2a
Genetic Background: SAMP3

 MP:0020550 multinucleated giant male germ cells "presence of large cells containing multiple nuclei formed abnormal opening of the cytoplasmic bridges that are part of normal germ cell division" [PMID:16272280, url:https://ntp.niehs.nih.gov/nnl/male_reproductive/testis/setubmgcel/index.htm]
Show

Allelic Composition: Pafah1b1tm1Awb/Pafah1b1+
Genetic Background: involves: 129S6/SvEvTac

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000046873 Q3TTC2 / Mbtps2 / Q8CHX6 / Membrane-bound transcription factor site-2 protease / O43462* / membrane bound transcription factor peptidase, site 2*  / reaction
 ENSMUSG00000031835 Mbtps1 / Q9WTZ2 / Membrane-bound transcription factor site-1 protease / Q14703* / membrane bound transcription factor peptidase, site 1*  / reaction






 

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