ENSMUSG00000027230


Mus musculus

Features
Gene ID: ENSMUSG00000027230
  
Biological name :Creb3l1
  
Synonyms : cAMP responsive element binding protein 3 like 1 / Creb3l1
  
Possible biological names infered from orthology : Q96BA8
  
Species: Mus musculus
  
Chr. number: 2
Strand: -1
Band: E1
Gene start: 91982328
Gene end: 92024502
  
Corresponding Affymetrix probe sets: 10485117 (MoGene1.0st)   1419295_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000028663
NCBI entrez gene - 26427     See in Manteia.
MGI - MGI:1347062
RefSeq - NM_011957
RefSeq Peptide - NP_036087
swissprot - A0A0R4J082
Ensembl - ENSMUSG00000027230
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 creb3l1ENSDARG00000015793Danio rerio
 CREB3L1ENSGALG00000008393Gallus gallus
 Q96BA8ENSG00000157613Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q8BH52 / Creb3l2 / Cyclic AMP-responsive element-binding protein 3-like protein 2 Processed cyclic AMP-responsive element-binding protein 3-like protein 2 / Q70SY1* / cAMP responsive elemen...ENSMUSG0000003864842
Q91XE9 / Creb3l3 / Cyclic AMP-responsive element-binding protein 3-like protein 3 Processed cyclic AMP-responsive element-binding protein 3-like protein 3 / Q68CJ9* / cAMP responsive elemen...ENSMUSG0000003504121
Creb3 / cAMP responsive element binding protein 3 / O43889*ENSMUSG0000002846617
Q9D2A5 / Creb3l4 / Cyclic AMP-responsive element-binding protein 3-like protein 4 Processed cyclic AMP-responsive element-binding protein 3-like protein 4 / Q8TEY5* / cAMP responsive elemen...ENSMUSG0000002793817


Protein motifs (from Interpro)
Interpro ID Name
 IPR001630  cAMP response element binding (CREB) protein
 IPR004827  Basic-leucine zipper domain
 IPR008917  Transcription factor, Skn-1-like, DNA-binding domain superfamily
 IPR029805  cAMP-responsive element-binding protein 3-like protein 1


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0030968 endoplasmic reticulum unfolded protein response IEA
 biological_processGO:0032967 positive regulation of collagen biosynthetic process IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:1902236 negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway IEA
 biological_processGO:1990440 positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0016020 membrane IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0035497 cAMP response element binding IEA
 molecular_functionGO:0044212 transcription regulatory region DNA binding IEA
 molecular_functionGO:0046332 SMAD binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000061 fragile skeleton "easily damaged or broken bones" [J:14208]
Show

Allelic Composition: FuzGt(OSTGST001398)Lex/FuzGt(OSTGST001398)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6N

 MP:0000063 reduced bone density "decreased mineral content of bone; indicator of bone strength" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:57315]
Show

Allelic Composition: FuzGt(OSTGST001398)Lex/FuzGt(OSTGST001398)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6N

 MP:0000135 reduced cortical bone thickness "thinner than normal superficial layer of compact bone " [J:61509]
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Allelic Composition: FuzGt(OSTGST001398)Lex/FuzGt(OSTGST001398)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6N

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: FuzGt(OSTGST001398)Lex/FuzGt(OSTGST001398)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6N

 MP:0002398 abnormal bone marrow cell morphology/development "anomalous structure or formation of the cells found in the bone marrow" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: FuzGt(OSTGST001398)Lex/FuzGt(OSTGST001398)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6N

 MP:0002968 increased circulating alkaline phosphatase level "elevated activity of this enzyme, which hydrolyzes orthophosphoric monoesters, found in the blood" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Crb2tm1a(KOMP)Wtsi/Crb2+
Genetic Background: C57BL/6N-Crb2tm1a(KOMP)Wtsi/Wtsi

 MP:0004986 abnormal osteoblast morphology "any structural anomaly of a bone-forming cell, which normally forms an osseous matrix (osteoid) in which it becomes enclosed as an osteocyte" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: FuzGt(OSTGST001398)Lex/FuzGt(OSTGST001398)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6N

 MP:0008395 abnormal osteoblast differentiation "atypical production of or inability to produce bone-forming cells, which normally form an osseous matrix (osteoid) in which they become enclosed as an osteocytes" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: FuzGt(OSTGST001398)Lex/FuzGt(OSTGST001398)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6N

 MP:0009346 decreased cancellous bone thickness "thinner than normal bone with a lattice-like or spongy structure" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: FuzGt(OSTGST001398)Lex/FuzGt(OSTGST001398)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6N

 MP:0020040 decreased bone ossification "decrease in the formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone or a bony substance" [ORCID: orcid.org/0000-0003-4606-0597]
Show

Allelic Composition: FuzGt(OSTGST001398)Lex/FuzGt(OSTGST001398)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6N

 MP:0020137 decreased bone mineralization "decrease in the rate at which minerals are deposited into bone" []
Show

Allelic Composition: FuzGt(OSTGST001398)Lex/FuzGt(OSTGST001398)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6N

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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