ENSG00000157613


Homo sapiens

Features
Gene ID: ENSG00000157613
  
Biological name :CREB3L1
  
Synonyms : cAMP responsive element binding protein 3 like 1 / CREB3L1 / Q96BA8
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 11
Strand: 1
Band: p11.2
Gene start: 46277661
Gene end: 46321422
  
Corresponding Affymetrix probe sets: 213059_at (Human Genome U133 Plus 2.0 Array)   213498_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000436574
Ensembl peptide - ENSP00000481956
Ensembl peptide - ENSP00000431677
NCBI entrez gene - 90993     See in Manteia.
OMIM - 616215
RefSeq - NM_052854
RefSeq - XM_006718380
RefSeq Peptide - NP_443086
swissprot - E9PK33
swissprot - H0YEU7
swissprot - Q96BA8
Ensembl - ENSG00000157613
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 creb3l1ENSDARG00000015793Danio rerio
 CREB3L1ENSGALG00000008393Gallus gallus
 Creb3l1ENSMUSG00000027230Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q70SY1 / CREB3L2 / cAMP responsive element binding protein 3 like 2ENSG0000018215843
Q68CJ9 / CREB3L3 / cAMP responsive element binding protein 3 like 3ENSG0000006056622
Q8TEY5 / CREB3L4 / cAMP responsive element binding protein 3 like 4ENSG0000014357819
CREB3 / O43889 / cAMP responsive element binding protein 3ENSG0000010717517


Protein motifs (from Interpro)
Interpro ID Name
 IPR001630  cAMP response element binding (CREB) protein
 IPR004827  Basic-leucine zipper domain
 IPR008917  Transcription factor, Skn-1-like, DNA-binding domain superfamily
 IPR029805  cAMP-responsive element-binding protein 3-like protein 1


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001649 osteoblast differentiation ISS
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0006986 response to unfolded protein IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0030968 endoplasmic reticulum unfolded protein response IEA
 biological_processGO:0032967 positive regulation of collagen biosynthetic process IDA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0070278 extracellular matrix constituent secretion ISS
 biological_processGO:1902236 negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway IEA
 biological_processGO:1990440 positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005783 endoplasmic reticulum IDA
 cellular_componentGO:0005789 endoplasmic reticulum membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding NAS
 molecular_functionGO:0001077 transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding ISS
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003682 chromatin binding ISS
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0035497 cAMP response element binding IEA
 molecular_functionGO:0044212 transcription regulatory region DNA binding IEA
 molecular_functionGO:0046332 SMAD binding IPI


Pathways (from Reactome)
Pathway description
CREB3 factors activate genes


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000140943 MBTPS1 / Q14703 / membrane bound transcription factor peptidase, site 1  / reaction
 ENSG00000012174 MBTPS2 / O43462 / membrane bound transcription factor peptidase, site 2  / reaction






 

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