ENSG00000060566


Homo sapiens

Features
Gene ID: ENSG00000060566
  
Biological name :CREB3L3
  
Synonyms : cAMP responsive element binding protein 3 like 3 / CREB3L3 / Q68CJ9
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 19
Strand: 1
Band: p13.3
Gene start: 4153601
Gene end: 4173054
  
Corresponding Affymetrix probe sets: 234361_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000078445
Ensembl peptide - ENSP00000469355
Ensembl peptide - ENSP00000470119
Ensembl peptide - ENSP00000472399
NCBI entrez gene - 84699     See in Manteia.
OMIM - 611998
RefSeq - NM_001271996
RefSeq - NM_001271995
RefSeq - NM_001271997
RefSeq - NM_032607
RefSeq Peptide - NP_001258924
RefSeq Peptide - NP_001258925
RefSeq Peptide - NP_001258926
RefSeq Peptide - NP_115996
swissprot - Q68CJ9
Ensembl - ENSG00000060566
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 creb3l3aENSDARG00000056226Danio rerio
 creb3l3bENSDARG00000090903Danio rerio
 CREB3L3ENSGALG00000001252Gallus gallus
 Q91XE9ENSMUSG00000035041Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q8TEY5 / CREB3L4 / cAMP responsive element binding protein 3 like 4ENSG0000014357832
CREB3 / O43889 / cAMP responsive element binding protein 3ENSG0000010717526
Q96BA8 / CREB3L1 / cAMP responsive element binding protein 3 like 1ENSG0000015761325
Q70SY1 / CREB3L2 / cAMP responsive element binding protein 3 like 2ENSG0000018215825


Protein motifs (from Interpro)
Interpro ID Name
 IPR004827  Basic-leucine zipper domain
 IPR008917  Transcription factor, Skn-1-like, DNA-binding domain superfamily
 IPR029806  cAMP-responsive element-binding protein 3-like protein 3


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002675 positive regulation of acute inflammatory response NAS
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0006986 response to unfolded protein IEA
 biological_processGO:0030968 endoplasmic reticulum unfolded protein response TAS
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IMP
 biological_processGO:1990440 positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress IDA
 cellular_componentGO:0000139 Golgi membrane TAS
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005783 endoplasmic reticulum IDA
 cellular_componentGO:0005789 endoplasmic reticulum membrane TAS
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0016020 membrane ISS
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0000976 transcription regulatory region sequence-specific DNA binding IDA
 molecular_functionGO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IDA
 molecular_functionGO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding ISM
 molecular_functionGO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding IMP
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0035497 cAMP response element binding IEA
 molecular_functionGO:0042803 protein homodimerization activity IDA
 molecular_functionGO:0046982 protein heterodimerization activity IPI


Pathways (from Reactome)
Pathway description
CREB3 factors activate genes
Assembly of active LPL and LIPC lipase complexes


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000140943 MBTPS1 / Q14703 / membrane bound transcription factor peptidase, site 1  / reaction
 ENSG00000012174 MBTPS2 / O43462 / membrane bound transcription factor peptidase, site 2  / reaction






 

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