ENSG00000107175


Homo sapiens

Features
Gene ID: ENSG00000107175
  
Biological name :CREB3
  
Synonyms : cAMP responsive element binding protein 3 / CREB3 / O43889
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 9
Strand: 1
Band: p13.3
Gene start: 35732335
Gene end: 35737004
  
Corresponding Affymetrix probe sets: 209432_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000342136
NCBI entrez gene - 10488     See in Manteia.
OMIM - 606443
RefSeq - NM_006368
RefSeq Peptide - NP_006359
swissprot - O43889
Ensembl - ENSG00000107175
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 creb3l3lENSDARG00000020926Danio rerio
 CREB3ENSGALG00000002523Gallus gallus
 Creb3ENSMUSG00000028466Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q68CJ9 / CREB3L3 / cAMP responsive element binding protein 3 like 3ENSG0000006056632
Q8TEY5 / CREB3L4 / cAMP responsive element binding protein 3 like 4ENSG0000014357829
Q70SY1 / CREB3L2 / cAMP responsive element binding protein 3 like 2ENSG0000018215825
Q96BA8 / CREB3L1 / cAMP responsive element binding protein 3 like 1ENSG0000015761324


Protein motifs (from Interpro)
Interpro ID Name
 IPR004827  Basic-leucine zipper domain
 IPR008917  Transcription factor, Skn-1-like, DNA-binding domain superfamily
 IPR029808  cAMP-responsive element-binding protein 3


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0006935 chemotaxis IEA
 biological_processGO:0006986 response to unfolded protein IEA
 biological_processGO:0006990 positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response IDA
 biological_processGO:0016032 viral process IEA
 biological_processGO:0030968 endoplasmic reticulum unfolded protein response TAS
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IMP
 biological_processGO:0090026 positive regulation of monocyte chemotaxis IDA
 biological_processGO:1902236 negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway IDA
 cellular_componentGO:0000139 Golgi membrane TAS
 cellular_componentGO:0005634 nucleus IC
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005783 endoplasmic reticulum IDA
 cellular_componentGO:0005789 endoplasmic reticulum membrane IEA
 cellular_componentGO:0005829 cytosol IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IDA
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IDA
 molecular_functionGO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding NAS
 molecular_functionGO:0000982 transcription factor activity, RNA polymerase II proximal promoter sequence-specific DNA binding IDA
 molecular_functionGO:0001077 transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding IMP
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0035497 cAMP response element binding IEA


Pathways (from Reactome)
Pathway description
CREB3 factors activate genes


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000164935 Q9H295 / DCSTAMP / dendrocyte expressed seven transmembrane protein  / complex
 ENSG00000164463 CREBRF / Q8IUR6 / CREB3 regulatory factor  / reaction / complex
 ENSG00000140943 MBTPS1 / Q14703 / membrane bound transcription factor peptidase, site 1  / reaction
 ENSG00000012174 MBTPS2 / O43462 / membrane bound transcription factor peptidase, site 2  / reaction






 

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