ENSMUSG00000026663


Mus musculus

Features
Gene ID: ENSMUSG00000026663
  
Biological name :Atf6
  
Synonyms : Atf6 / Cyclic AMP-dependent transcription factor ATF-6 alpha Processed cyclic AMP-dependent transcription factor ATF-6 alpha / F6VAN0
  
Possible biological names infered from orthology : activating transcription factor 6 / P18850
  
Species: Mus musculus
  
Chr. number: 1
Strand: -1
Band: H3
Gene start: 170704674
Gene end: 170867771
  
Corresponding Affymetrix probe sets: 10359982 (MoGene1.0st)   1435444_at (Mouse Genome 430 2.0 Array)   1453288_at (Mouse Genome 430 2.0 Array)   1456021_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000027974
NCBI entrez gene - 226641     See in Manteia.
MGI - MGI:1926157
RefSeq - XM_011238796
RefSeq - NM_001081304
RefSeq - XM_006496792
RefSeq Peptide - NP_001074773
swissprot - F6VAN0
Ensembl - ENSMUSG00000026663
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 atf6ENSDARG00000012656Danio rerio
 ATF6ENSGALG00000032278Gallus gallus
 ATF6ENSG00000118217Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Atf6b / activating transcription factor 6 beta / Q99941*ENSMUSG0000001546132


Protein motifs (from Interpro)
Interpro ID Name
 IPR004827  Basic-leucine zipper domain
 IPR008917  Transcription factor, Skn-1-like, DNA-binding domain superfamily
 IPR029801  cAMP-dependent transcription factor ATF-6 alpha


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001654 eye development IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006986 response to unfolded protein IEA
 biological_processGO:0007601 visual perception IEA
 biological_processGO:0030968 endoplasmic reticulum unfolded protein response IEA
 biological_processGO:0043065 positive regulation of apoptotic process IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II ISO
 biological_processGO:1903893 positive regulation of ATF6-mediated unfolded protein response IEA
 biological_processGO:1990440 positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress IEA
 cellular_componentGO:0005634 nucleus NAS
 cellular_componentGO:0005783 endoplasmic reticulum NAS
 cellular_componentGO:0005789 endoplasmic reticulum membrane IEA
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0016020 membrane ISO
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030176 integral component of endoplasmic reticulum membrane IEA
 molecular_functionGO:0000976 transcription regulatory region sequence-specific DNA binding IEA
 molecular_functionGO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IEA
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity ISO
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0031625 ubiquitin protein ligase binding IEA
 molecular_functionGO:0035497 cAMP response element binding IEA
 molecular_functionGO:0042802 identical protein binding IEA
 molecular_functionGO:0043565 sequence-specific DNA binding IEA
 molecular_functionGO:0046982 protein heterodimerization activity IEA


Pathways (from Reactome)
Pathway description
ATF6 (ATF6-alpha) activates chaperones


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000352 decreased cell proliferation "less than the normal growth and reproduction of similar cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Ltbp3m1Btlr/Ltbp3m1Btlr
Genetic Background: either: C57BL/6J-Ltbp3m1Btlr or (involves: C3H/HeJ * C57BL/6J)

 MP:0002628 fatty liver "an accumulation of fat deposits in the liver " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Ltbp3m1Btlr/Ltbp3m1Btlr
Genetic Background: either: C57BL/6J-Ltbp3m1Btlr or (involves: C3H/HeJ * C57BL/6J)

 MP:0002891 increased insulin sensitivity "greater ability to clear glucose from the bloodstream when given insulin than normal; can result in hypoglycemia" [RGD:Rat Genome Database submission]
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Allelic Composition: Igsf9tm2Kln/Igsf9tm2Kln
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005621 abnormal cell physiology "aberration in the vital processes of the cell " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, hdene:Howard Dene , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ltbp3m1Btlr/Ltbp3m1Btlr
Genetic Background: either: C57BL/6J-Ltbp3m1Btlr or (involves: C3H/HeJ * C57BL/6J)

 MP:0008873 increased sensitivity to xenobiotics "decrease in the dose or concentration of a foreign compound required to induce a specific level of response" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ltbp3m1Btlr/Ltbp3m1Btlr
Genetic Background: either: C57BL/6J-Ltbp3m1Btlr or (involves: C3H/HeJ * C57BL/6J)

 MP:0008874 decreased sensitivity to xenobiotics "increase in the dose or concentration of a foreign compound required to induce a specific level of response" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Igsf9tm2Kln/Igsf9tm2Kln
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Atf6tm1Hota/Atf6tm1Hota,Tg(Ins2-cre)25Mgn/0,Tg(Ins2-GP)1Kbuw/0
Genetic Background: involves: C57BL/6 * DBA

 MP:0008943 increased sensitivity to induced cell death "decrease in the exposure level to an agent that is required to induce cessation of function at the cellular level" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gabbr2tm1Arca/Gabbr2tm1Arca
Genetic Background: involves: 129P2/OlaHsd

 MP:0009766 increased sensitivity to xenobiotic induced morbidity/mortality "decrease in the amount of a foreign compound required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ltbp3m1Btlr/Ltbp3m1Btlr
Genetic Background: either: C57BL/6J-Ltbp3m1Btlr or (involves: C3H/HeJ * C57BL/6J)

 MP:0011091 complete prenatal lethality "death of all organisms of a given genotype in a population between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Gabbr2tm1Arca/Gabbr2tm1Arca
Genetic Background: involves: 129P2/OlaHsd

 MP:0014121 increased pancreatic islet cell apoptosis "increase in the number of pancreatic islet cells undergoing programmed cell death" [MGI:Anna]
Show

Allelic Composition: Igsf9tm2Kln/Igsf9tm2Kln
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0020352 abnormal endoplasmic reticulum physiology "any functional anomaly of the irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells" [GO:0005783, ORCID: orcid.org/0000-0003-4606-0597]
Show

Allelic Composition: Ltbp3m1Btlr/Ltbp3m1Btlr
Genetic Background: either: C57BL/6J-Ltbp3m1Btlr or (involves: C3H/HeJ * C57BL/6J)

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000026864 Hspa5 / P20029 / heat shock protein 5 / P11021* / heat shock protein family A (Hsp70) member 5*  / complex
 ENSMUSG00000091736 Yy2 / Q3TTC2 / Yy2 transcription factor / O15391*  / reaction
 ENSMUSG00000046873 Q3TTC2 / Mbtps2 / Q8CHX6 / Membrane-bound transcription factor site-2 protease / O43462* / membrane bound transcription factor peptidase, site 2*  / reaction
 ENSMUSG00000031835 Mbtps1 / Q9WTZ2 / Membrane-bound transcription factor site-1 protease / Q14703* / membrane bound transcription factor peptidase, site 1*  / reaction






 

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